10 Low Platelet Count Causes (Disease-Induced) (2022)

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Blood is anessential component of the human body composed of cells and plasma. Plasma is the liquid part that constitutes 55 percent of the blood. The solid part isformed by cells – namely, the red blood cells, white blood cells, and the platelets (thrombocyte cell fragments).

Red blood cells or RBCs are responsiblefor carrying oxygen to different parts of the body and white blood cells or WBCs are responsiblefor fighting off infection.

While platelets are needed by the body to stop bleeding. This happens along withother proteins and components in the blood which help in the blood clotting process, known as coagulation factors.

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    10 Low Platelet Count Causes (Disease-Induced) (1)

The cellular components of the blood are formed in a sponge-like tissuecalled the bone marrow which is locatedinside long bones. Theblood cellsform and mature in the bone marrow and eventually passed into circulation, in the bloodstream.

However, many diseases can affect production of cells, creating an influence on cellular count such asthe platelet count.It will certainly be a horrible position to experience sudden and uncontrolled gushing out of blood from the nose, gums and other openings of the body.

And sadly, it could happen with a really low platelet count. Before that happens, better manage the drop immediately. This mayusually be a costly endeavor butthere are affordable options such as all-natural remedies you can learn from money back guaranteed materials like Conquer Low Platelets.

10 Low Platelet Count Causes (Disease-Induced) (2)

A reduced platelet count can only result from three basic mechanisms:

  1. Reduced production.
  2. Increased destruction.
  3. Sequestration or consumption.

All of the diseases listed below fall in at least one of these categories.

Low Platelet Count Causes (By MedicalCondition)

The following medical conditions are observed to cause a low platelet count:

(Video) Thrombocytopaenia (low platelets) Overview - platelet physiology, classification, pathophysiology

1. Dengue Fever.

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Dengue fever is a mosquito-borne tropical disease caused by a viral infection. Somepatients experience the development of the condition into a life-threatening stagereferred to as dengue-hemorrhagic fever, where bleeding, blood plasma leakage, and low platelet count takes place.

The drop in platelet levelsisaresult of the attack brought about by thevirus against the tissue where platelets areproduced, thebone marrow.

The treatment foracute dengue is supportive in approach, using either oral or intravenous rehydration for mild or moderate cases. Intravenous fluids and blood transfusionare included in severe cases of themedical condition. Hospitalization is required in themanagement of dangerously low platelet count.

2. HIV infection.

HIV is a rapidly spreading viral infection that also causes a reduction in platelet count. HIV can affect any organ of the body which includesthebone marrow, altering platelet production.

The treatment of HIV-induced reduction in platelet count is called HAART or Highly Active Anti-Retroviral Therapy. It is aimed at reducing the viral load and preventing further destruction of the bone marrow by giving time for the platelets to revive.

3. Drug-induced.

10 Low Platelet Count Causes (Disease-Induced) (4)

Certain drugs such as paracetamol, diclofenac, fluconazole, ibuprofen, naproxen, etc. can cause low platelet count indifferent ways. Withdrawing the causative drug is the managementof choice for adrug-induced low platelet count.

In some cases, the platelet count may fall dangerously low and the patient may require hospitalization. The treatmentmay be refocused on management of any developed complications along with effectively preventing death.

Read more:

(Video) Low Platelets: Causes, conditions and treatment

4. Heparin-induced.

Heparin is a drug used in thrombotic situationssuch as pulmonary thromboembolism. A thrombotic state is a situation when abnormal blood clots form due to certain factor/s. Heparin-induced thrombocytopenia or HIT is different in the way it causes low platelets in comparisonto other drugs.

In fact, heparin can cause an increased tendency of formingmore blood clots as opposed to increasing the chances of bleeding. This may sound contradicting but it does happen in many occasions. The reason it happens is centered on HIT antibodies that may haveformed against platelet protein which eventually activates the platelets.

The activated platelets cause increased clot formation, while consuming a lot of platelets in the process, resulting toa low platelet count.

5. Idiopathic or ImmuneThrombocytopenic Purpura.

ITP is an immune mediated causative factor for reduced platelets in the body. It isdefined as the occurrence of isolated low platelet count butwith anormally functioning bone marrowand the absence of other causes of thrombocytopenia such as secondary immune-, drug-, or viral-induced cases. The destruction of platelets takes place in the bloodstream and the spleen.

ITPcauses a characteristicpurpuric rash along withan increased tendency to bleed. This autoimmune condition that causes thedestruction ofblood plateletsin patientsisclassified asprimary thrombocytopenic purpura.Read about ITP treatment methods.

6. Thrombotic Thrombocytopenic Purpura.

TTP is caused by a deficiency of an enzyme that cleaves von Willebrand factor. It can also be a result of a destruction of the enzyme by antibodies.

Von Willebrand factor, when cleaved, acts upon platelets, normally preventingadhesion and aggregation, to keepblood from clotting together as it should innormal circumstances. Thiskeeps the blood flowing freely in the bloodstream.

In the absence of the cleaving, however, the platelets adhere and aggregate to one another forming blood clots. This leads to increased consumption of platelets resulting toa low platelet count.TTP can be inherited or idiopathic. The inherited form of the disease is called the Upshaw Shulman syndrome.

(Video) Low Platelets: Signs & Symptoms (Basics for Beginners)

7. Hemolytic Uremic Syndrome.

10 Low Platelet Count Causes (Disease-Induced) (5)

HUS is mostly preceded by a severe and ignored case of bloody diarrhea. This results in reduced blood flow to the kidneys due to severe dehydration whichmay eventually lead to kidney damage.

The loss of blood through the gut in the form of diarrhea is directly responsible for the reduced platelet count in HUS. There is another form of HUS which is hereditary in natureand not associated with diarrhea.

The treatment is supportive and revolves around correction of dehydration and prevention of complications that can take place due toreduced platelets.

8. Pregnancy-induced.

Reduced platelets in pregnancy can be due to medical conditions such as connective tissue disorders, viral infections, and hypersplenism. But the most notable of disorders is HELLP syndrome.

This can result from the increase in blood pressure which is directly influenced by the course of pregnancy itself. It is usually managed with intake of drugs, safe for use during pregnancy, like magnesium sulphate that lowers blood pressure levels. However, there are cases of mild drops in platelet count during pregnancy that can be considered normal.

9. MYH9-related disorders.

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Myosin heavy chain 9 (MYH9)-related platelet diseases belong to the group of inherited thrombocytopenia. May Hegglin anomaly, Sebastian, Epstein and Fechtner anomalies however, are rare causes of reduced platelet count.

(Video) Thrombocytopenia | Signs and Symptoms and Approach to Causes

Each of these has acommon feature – the presence of large platelets as can be seen on microscopy. But their distinctive featuresdifferentiate one from the other. These diseases can be inherited in any one of the many forms such as autosomal dominant, autosomal recessive, or X-linked recessive.

10. Evans syndrome.

This is a disease that presents a diagnostic dilemma even to many physicians. It is very similar to HUS in presentation. Evans syndrome can only be differentiated by a blood test called Coombs test.

The main complication of low platelet count is thetendency to bleed, but depending on the location of bleeding, it will produce different symptoms. For example, if the bleed occurs inside the brain, the symptoms will be nausea, vomiting, loss of consciousness, etc.

10 Low Platelet Count Causes (Disease-Induced) (7)

Key Takeaway:

The medical disorders that may result to a display of reduction in platelet count are not exclusive to the list above but many cases fall under one of these. As true for a lot of diseases, not every condition can be conclusively diagnosed and treated for good, but can be managed. The management of low platelet count is grounded on the associated underlying specific medical condition.

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FAQs

What disease causes low platelet count? ›

Autoimmune diseases, such as lupus and rheumatoid arthritis, cause this type. The body's immune system mistakenly attacks and destroys platelets. If the exact cause of this condition isn't known, it's called idiopathic thrombocytopenic purpura. This type more often affects children.

What happens if platelet count is low? ›

If left untreated, a low platelet count can be very serious because it can cause internal bleeding of the brain or the intestines. In the worst cases, this may even cause death. That is why it is essential to seek medical care if you think you might be at risk.

How can the causes of a low platelet count be classified? ›

Causes of thrombocytopenia can be classified into three groups: Diminished production (caused by viral infections, vitamin deficiencies, aplastic anemia, drug-induced) Increased destruction (caused by drugs, heparin [HIT], idiopathic, pregnancy, immune system)

What causes low blood count? ›

Missing certain vitamins or minerals in the diet because of not eating enough. Low iron levels in blood. Major organ problems (including severe heart, lung, kidney, or liver disease) Red blood cells (RBCs) being destroyed by the body before they're replaced.

What cancers cause low platelets? ›

Certain cancers such as leukemia or lymphoma can lower your platelet count. The abnormal cells in these cancers can crowd out healthy cells in the bone marrow, where platelets are made. Less common causes of a low platelet count include: Cancer that spreads to the bone.

Can viral infection cause low platelet count? ›

Viruses can trigger a decrease in platelet production by (I) infection of megakaryocytes, which can lead to (A) apoptosis of megakaryocytes, (B) decreased maturation and ploidy of megakaryocytes, or (C) decreased expression of thrombopoietin receptor c-Mpl.

Can depression cause low platelets? ›

Platelet BDNF levels have been measured in depressed patients and have been found to be decreased when compared to normal controls. However plasma BDNF levels have been found to be increased in these same patients when compared to controls[91].

How do you treat low platelets? ›

If your platelet level becomes too low, your doctor can replace lost blood with transfusions of packed red blood cells or platelets. Medications. If your condition is related to an immune system problem, your doctor might prescribe drugs to boost your platelet count. The first-choice drug might be a corticosteroid.

How common is low platelets? ›

It's unknown how many people have thrombocytopenia. Many people have mild symptoms. They might not even know they have the condition. The autoimmune form of thrombocytopenia, immune thrombocytopenic purpura or ITP, affects approximately three to four out of every 100,000 adults and children.

What is a low platelet count called? ›

Thrombocytopenia is a condition that occurs when the platelet count in your blood is too low.

Can low platelets cause headaches? ›

Signs of inadequate platelets include bleeding or bruising too easily. Patients may experience bleeding of the gums when brushing their teeth, blood in the urine or stool, severe headache or visual changes or a stiff neck.

Is low blood count serious? ›

The most serious complications of low blood cell counts include: Infection. With a low white blood cell count and, in particular, a low level of neutrophils, you're at higher risk of developing an infection. And if you develop an infection when you have a low white blood cell count, your body can't protect itself.

What blood count is too low? ›

An adult has anemia, or is considered anemic, when their hemoglobin level falls to about 100g/L or less. A child has anemia if the hemoglobin is 75 g/L or less. Symptoms of anemia may develop even if the hemoglobin is higher than these levels.

Can low platelets cause death? ›

If your platelet count is extremely low, you could start bleeding internally all by itself. If untreated, a very low platelet count could be fatal.

Why do platelets decrease? ›

Decreased production of platelets

Certain types of anemia. Viral infections (chickenpox, hepatitis C, HIV, etc.) Chemotherapy drugs. Heavy alcohol consumption.

Can low platelets turn into leukemia? ›

Blood cells are produced in the bone marrow. In those with myelodysplatic syndrome (MDS) the bone marrow is damaged and blood cell production is impaired, including platelet production. The disease can also transform into acute myeloid leukemia (AML).

What medications cause low platelets? ›

Causes
  • Furosemide.
  • Gold, used to treat arthritis.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Penicillin.
  • Quinidine.
  • Quinine.
  • Ranitidine.
  • Sulfonamides.
22 Jul 2021

Can a bacterial infection cause low platelets? ›

Low Platelets Caused by Infectious Diseases. In most cases of thrombocytopenia caused by bacteria or a virus, the treatment approach is to treat the underlying infection.

How much platelets increase per day? ›

Typical dosing for an adult is a pool of 6 whole blood derived (sometimes referred to as random donor) platelets or one apheresis platelet. This is expected to raise the platelet count by 30,000-60,000/uL in a 70 kg patient.

Can extreme stress cause low platelets? ›

The factor “acute mental stress” was associated with alterations in CD62P+ platelets (p < 0.001), CD63+ platelets (p = 0.011), PAC-1+ platelets (p < 0.001) as well as platelet leucocyte aggregates (p = 0.019).

Is low platelet count rare? ›

Thrombotic thrombocytopenia purpura (TTP) is a rare, but quite serious blood disease. In adults it is found most commonly in young females; the rare cases in children are more common in adolescent females.

Can stress and anxiety cause low platelets? ›

Acute psychological stress can similarly affect platelet function,42 particularly among those prone to anxiety. Platelets are activated by their interaction with various circulating agonists (including serotonin and catecholamines) via separate and specific receptors in the platelet membrane.

Can water increase platelets? ›

A steady intake of water increases hemoglobin indices, such as the MCH and MCHC, and decreases the MPV. As shown in Table 1, at the end of the study period, WBC, RBC, and platelet counts increased in the experimental group, as did hematocrit and hemoglobin levels, although the increases were not significant ( p >0.05).

Does milk increase platelets? ›

It's no secret that fresh milk contains calcium, which is an essential mineral for strengthening and developing bones. But did you know that fresh milk also helps regenerate blood platelets. Moreover, milk contains Vitamin K, which is absolutely essential for proper blood clotting.

Do platelets drop with age? ›

Platelet count remains relatively stable during middle age (25–60 years old) but falls in old age (60+), decreasing by approximately 8 %, or 20,000 platelets/μl, between 50- and 59-year-old subjects and those over 70 years old (Segal and Moliterno 2006).

How long can you live without platelets? ›

Potential Benefits of Continuing Transfusions

Platelets transfusions can stop or prevent bleeding caused by severe thrombocytopenia within hours but usually have a life span of only 4-8 days (4).

What are the 3 functions of platelets? ›

While the primary function of the platelet is thought to be hemostasis, thrombosis, and wound healing through a complex activation process leading to integrin activation and formation of a “core” and “shell” at the site of injury, other physiological roles for the platelet exist including immunity and communication ...

Can low platelets cause dizziness? ›

Symptoms of Low Platelets

Headache, confusion, or dizziness.

What is the normal platelet count by age? ›

Putting this together, we determined the following platelet count reference intervals for seniors aged 60 years and older: 165–355 × 109/L for females, and 150–300 × 109/L (60–69 years), 130–300 (70–79 years), and 120–300 (80 years and above) for males.

How increase platelet count fast medicine? ›

Romiplostim injection is used to increase the number of platelets (cells that help the blood to clot) in order to decrease the risk of bleeding in adults who have immune thrombocytopenia (ITP; idiopathic thrombocytopenic purpura; an ongoing condition that may cause easy bruising or bleeding due to an abnormally low ...

Can low platelets cause eye problems? ›

Thrombocytopenia alone, even severe (a platelet count <50 000), is rarely sufficient to cause significant retinal hemorrhage. However, thrombocytopenia combined with anemia is a known risk factor,9 and retinal hemorrhages in association with ITP have only been reported to occur with concurrent anemia.

How do you raise low platelets? ›

People with a low platelet count may be able to improve their condition by eating specific foods and taking certain supplements. Foods that may be of benefit include those containing folate and those rich in vitamins B12, C, D, or K. Supplements that may help include chlorophyll and papaya leaf extract.

How do you treat low platelets? ›

If your platelet level becomes too low, your doctor can replace lost blood with transfusions of packed red blood cells or platelets. Medications. If your condition is related to an immune system problem, your doctor might prescribe drugs to boost your platelet count. The first-choice drug might be a corticosteroid.

What medications cause low platelets? ›

Causes
  • Furosemide.
  • Gold, used to treat arthritis.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Penicillin.
  • Quinidine.
  • Quinine.
  • Ranitidine.
  • Sulfonamides.
22 Jul 2021

Can depression cause low platelets? ›

Platelet BDNF levels have been measured in depressed patients and have been found to be decreased when compared to normal controls. However plasma BDNF levels have been found to be increased in these same patients when compared to controls[91].

Can thrombocytopenia be cured? ›

A: While there is no cure for ITP, many patients find their platelet count improves following treatment. What proves difficult for many ITP patients is finding the treatment that works for them without unwanted side effects. Some patients report that changing their diet or lifestyle helps them feel better.

Can water increase platelets? ›

A steady intake of water increases hemoglobin indices, such as the MCH and MCHC, and decreases the MPV. As shown in Table 1, at the end of the study period, WBC, RBC, and platelet counts increased in the experimental group, as did hematocrit and hemoglobin levels, although the increases were not significant ( p >0.05).

Why platelets will decrease? ›

Low platelets, or thrombocytopenia, are a common side effect of blood cancers and their treatment. They can also be caused by autoimmune diseases, pregnancy, heavy alcohol consumption, or certain medications. When you have low platelets, you may have frequent or excessive bleeding.

Do platelets drop with age? ›

Platelet count remains relatively stable during middle age (25–60 years old) but falls in old age (60+), decreasing by approximately 8 %, or 20,000 platelets/μl, between 50- and 59-year-old subjects and those over 70 years old (Segal and Moliterno 2006).

Can viral infection cause low platelet count? ›

Viruses can trigger a decrease in platelet production by (I) infection of megakaryocytes, which can lead to (A) apoptosis of megakaryocytes, (B) decreased maturation and ploidy of megakaryocytes, or (C) decreased expression of thrombopoietin receptor c-Mpl.

Can extreme stress cause low platelets? ›

The factor “acute mental stress” was associated with alterations in CD62P+ platelets (p < 0.001), CD63+ platelets (p = 0.011), PAC-1+ platelets (p < 0.001) as well as platelet leucocyte aggregates (p = 0.019).

Can stress and anxiety cause low platelets? ›

Acute psychological stress can similarly affect platelet function,42 particularly among those prone to anxiety. Platelets are activated by their interaction with various circulating agonists (including serotonin and catecholamines) via separate and specific receptors in the platelet membrane.

Can anxiety affect platelet count? ›

Stressful life events and anxiety usually cause an increase in platelet volume and activity through various mechanisms. Mean platelet volume (MPV), which is indicative of platelet size, is accepted as an indication of platelet activity.

Can B12 increase platelets? ›

Vitamin B-12 helps keep your blood cells healthy. A deficiency of B-12 has been associated with low platelet counts. The best sources of vitamin B-12 tend to be animal-based foods, such as: beef liver.

What are 3 causes of thrombocytopenia? ›

These conditions include:
  • Pregnancy. Low platelet count caused by pregnancy is typically mild. ...
  • Immune thrombocytopenia. ...
  • Thrombotic thrombocytopenic purpura. ...
  • Hemolytic uremic syndrome. ...
  • Bacteria in the blood. ...
  • Medications.
6 Dec 2021

How long can you live without platelets? ›

Potential Benefits of Continuing Transfusions

Platelets transfusions can stop or prevent bleeding caused by severe thrombocytopenia within hours but usually have a life span of only 4-8 days (4).

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