Citrullinated proteins in Rheumatoid Arthritis (2022)

Table of Contents
Reumatología Clínica (English Edition) Abstract Resumen References (40) Biochem Byophys Res Commun. J Biol Chem. Epidemiology of rheumatoid arthritis: update Epidem Rev. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis Arthritis & Rheum. The American Rheumatism Association 1987 revised criteria for classification of Rheumatoid Arthritis Arthitis & Rheum. Immune complex can trigger specific, T-cell dependent, autoanti-IgG antibody production in mice J Exp Med. Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study Arthritis & Rheum. The prognostic value of the antiperinuclear factor, anticitrullinated peptide autoantibodies and rheumatoid factor in early rheumatoid arthritis Clin Exp Rheumatol. Diagnostic value of anti-cyclic citrullinated peptide antibody in patients with rheumatoid Arthritis J Rheumatol. The antiperinucleal factor and the so called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies J Clin Invest. Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin Arthritis Res Ther. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide Arthritis Rheum. Citrullination: a small change for a protein with great consequences for rheumatoid arthritis Arthritis Res. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors Arthritis & Rheum. Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with older age at time of disease diagnosis Ann Rheum Dis. PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease Bioassays. Localization of peptidylarginine deiminase 4(PADI4) and citrullinated proteinin synovial tissue of rheumatoid arthritis Rheumatology. Synovial fluid is a site citrullination of autoantigens in inflammatory arthritis Arthritis & Rheum. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis Nat Genet. Cited by (0) Recommended articles (6) Videos
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Reumatología Clínica (English Edition)

Volume 7, Issue 1,

2011

, Pages 68-71

Abstract

Rheumatoid arthritis is an autoimmune disease of multifactorial etiology characterized by inflammation of the joints and presence of autoantibodies directed against multiple autoantigens. Recently the study of the anti-citrullinated protein antibodies (ACP) has acquired great interest due to its high specificity and sensitivity for diagnosis, in addition to which it has shown to be a predictor of severity in patients with rheumatoid arthritis, suggesting an important participation in the pathogenesis of the disease.

(Video) Anti-Cyclic Citrullinated Peptide (anti-CCP)

Resumen

La artritis reumatoide es una enfermedad autoinmune de etiología multifactorial caracterizada por inflamación de las articulaciones y presencia de múltiples autoanticuerpos. Recientemente, el estudio de los anticuerpos antiproteínas citrulinadas (APS) ha adquirido gran interés debido a su alta especificidad y sensibilidad para el diagnóstico, además de que se ha demostrado que es predictor de severidad en pacientes con artritis reumatoide; lo cual sugiere un papel importante en la patogénesis de la enfermedad.

References (40)

  • A. Suzuki et al.Anticitrullinated collagen type I antibody is a target of autoimmunity in rheumatoid arthritis

    Biochem Byophys Res Commun.

    (2005)

  • E. Tarcsa et al.Protein unfolding by peptidylarginine deiminase. Substrate specificity and structural relation ships of the natural substrate strichohyalin and filaggrin

    J Biol Chem.

    (1996)

  • M.C. Hochberg et al.

    Epidemiology of rheumatoid arthritis: update

    Epidem Rev.

    (1990)

  • Pascual GE. Manifestaciones clínicas articulares. In: Arán, editor. Tratado de Reumatología. España. 1998; p....
  • P.K. Gregersen et al.

    The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

    Arthritis & Rheum.

    (1987)

  • F.C. Arrnett et al.

    The American Rheumatism Association 1987 revised criteria for classification of Rheumatoid Arthritis

    Arthitis & Rheum.

    (1988)

  • D. Nemazee

    Immune complex can trigger specific, T-cell dependent, autoanti-IgG antibody production in mice

    J Exp Med.

    (1985)

  • F.A. Van Gaalen et al.

    Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study

    Arthritis & Rheum.

    (2004)

  • C.H. Van Jaarsveld et al.

    The prognostic value of the antiperinuclear factor, anticitrullinated peptide autoantibodies and rheumatoid factor in early rheumatoid arthritis

    Clin Exp Rheumatol.

    (1999)

  • X. Zeng et al.

    Diagnostic value of anti-cyclic citrullinated peptide antibody in patients with rheumatoid Arthritis

    J Rheumatol.

    (2003)

  • M. Sebbag et al.

    The antiperinucleal factor and the so called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies

    J Clin Invest.

    (1995)

  • E.R. Vossenaar et al.

    Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin

    Arthritis Res Ther.

    (2004)

  • G.A. Schellekens et al.

    The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide

    (Video) Rheumatoid arthritis - causes, symptoms, diagnosis, treatment, pathology

    Arthritis Rheum.

    (2000)

  • W.J. Van Venrooij et al.

    Citrullination: a small change for a protein with great consequences for rheumatoid arthritis

    Arthritis Res.

    (2000)

  • M.M. Nielen et al.

    Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors

    Arthritis & Rheum.

    (2004)

  • D.S. Majka et al.

    Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with older age at time of disease diagnosis

    Ann Rheum Dis.

    (2008)

  • E.R. Vossenaar et al.

    PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease

    Bioassays.

    (2003)

  • X. Chang et al.

    Localization of peptidylarginine deiminase 4(PADI4) and citrullinated proteinin synovial tissue of rheumatoid arthritis

    Rheumatology.

    (2005)

  • A. Kinloch et al.

    Synovial fluid is a site citrullination of autoantigens in inflammatory arthritis

    Arthritis & Rheum.

    (2008)

  • A. Suzuki et al.

    Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

    Nat Genet.

    (2003)

  • Cited by (0)

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    Copyright © 2011 Sociedad Española de Reumatología and Colegio Mexicano de Reumatología. Published by Elsevier España S.L. All rights reserved.

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