Dental implants have helped millions of men and women enjoy greater confidence, improved facial aesthetics and better oral function following tooth loss. And for the vast majority of patients, the implant process is straightforward and uneventful, with no serious side effects or complications.
But invery few cases, patients may have allergic reactions to the titanium metal used in dental implants. In past blog posts, we’ve discussed the possible complications and risks associated withmercury amalgam fillingsand thepros and cons of zirconia implants compared to titanium implantsto help you become more aware and informed. In this post, we delve a little deeper into titanium allergies so you can understand how to assess your risk forallergicreaction and feel more confident about your oral health care. Here’s what you should know.
How common are titanium allergies?
Titanium allergies are rare, occurring in about 0.6% of the population,according to one study. That means as many as 1.8 million people in the U.S. may be allergic to titanium to some degree. Other studies suggest the allergic reaction or hypersensitivity to titanium could be much higher. When they do occur, titanium allergy symptoms can range from mild to severe and can include:
- loosening of the implants (or implant failure)
- rash or hives
- sores and swelling in the soft tissues of the mouth
- chronic inflammationinthe gums around the implant
- problems with wound healing
- chronic fatigue syndrome
- acne-like swelling or inflammation of the face
- muscle and joint achiness
- neurological problems
Even though the risk of titanium allergy may be quite low, the reactions can have significant impacts on your overall health and wellness -- which brings us to the next issue: How can you tell if you’re allergic to titanium?
Titanium Allergy Test
Many allergies can be diagnosed through a simple method called a skin patch test. In these tests, suspected allergens are applied to very small areas of skin, usually on your back. Then these areas are covered with waterproof bandages and left alone for a period of time. When the time elapses, the skin areas are evaluated for signs of irritation that indicate an allergic reaction.
But while skin patch tests are ideal for some types of allergies, they’re not very accurate for other, including titanium allergies. To test for a titanium allergy, you’ll need to have a different type of test calledMELISA(which is short for (Memory Lymphocyte Immunostimulation Assay). MELISA uses a small sample of your blood to check for titanium sensitivity. During the assay, your white blood cells are isolated from the rest of your blood, then exposedto titanium. Over several days, your blood sample is evaluated for signs of allergic reaction. MELISA offers far more accurate resultsthattraditional skin patch allergy tests, especially for applications where the metal will come in contact with bone and soft tissues. In fact, in addition to its use in dentistry, it’s also used to test for metal allergies prior to joint replacement surgery, and it’s used in other industries where metal allergies are a concern. The table below shows some of the metal allergies that can be evaluated using MELISA. IMPORTANT: HELM NEJAD STANLEY DOES NOT ADMINISTER THE MELISA TEST AND THE PATIENT MUST CONTACT THE COMPANY IN GERMANY ON THEIR OWN.
Chart presents stimulation index of tested metals.
- Gold - 1
- Cobalt - 3
- Chromium - 4
- Palladdium - 10
- Titanium - 6
- Tin - 8
- Nickel - 27
- Cadmium - 10
- Phenyl mercury - 5
- Inorganic mercury - 12
(Photo Courtesy of MELISA.org)
First chart presents MELISA reactivity in a 54-yer-old man before and after removal of Ti-based dental implants and screws. Numbers represents stimulation index.
- Ti: before - 70, after - 1
- Ni: before - 8, after - 2
- Pt: before - 6, after - 0.5
- Cd: before - 3, after - 0
- In: before - 2.5, after - 0
- Be: before - 1, after - 0
- Pd: before - 1, after - 0
- Au: before - 1, after - 0
- Cu: before - 0.5, after - 0
- Pb: before - 0.25, after - 0
Second chart presents MELISA reactivity in a 14-yer-old girl before and after removal of Ti-based brackets. Numbers represents stimulation index.
- Ti: before - 8.5, after - 1.5
- Ni: before - 2, after - 1.5
- Pt: before - 1, after - 1.1
- Cd: before - 2, after - 1.7
- In: before - 0.5, after - 0.5
- Be: before - 1, after - 0.85
- Pd: before - 2, after - 1.9
- Au: before - 1, after - 0.8
- Cu: before - 2, after - 1.8
- Pb: before - 0.75, after - 0.25
How accurate is MELISA?
MELISA can be far more accurate than skin patch tests because MELISA shows how the metal will react when it comes in contact with blood and tissue inside your body rather than just the surface of the skin. Still, there have been some studies that question the accuracy and reliability of the test.
In one study from 2016, 57% of patients who claimed an allergy to titanium reacted to other metals, including nickel. This is especially concerning since even the purest titanium contains a traceamount of nickel. And that means if you have an allergy to nickel, you may have an allergic reaction to dental implants that use the metal. Nickel allergies are extremely common; in fact, after poison ivy, they’re the most common cause of allergic skin rashes. Moreover, MELISA has not been completely accepted as 100% reliable by the medical or research communities, which means you’re more or less left on your own to decide if you feel confident in the results of your test prior to receiving implants. As a result, many patients -- even those with no known titanium allergies -- opt for other alternatives to replace their missing teeth in order to avoid the possible risks associated with titanium allergic reactions.
Zirconia Dental Implants: An Alternative to Titanium
So what if your test shows youareallergic to titanium? Does that mean you have to forego implants in favor of a denture or bridge? No. For patients who test positive for titanium allergy, zirconiadental implantscould be a good solution. Zirconia is made primarily of ceramic rather than titanium. As a result, you won’t have to worry about allergic reactions. Why aren't zirconiadental implantsused all the time? Well, in part because theylack some of the features of titanium implants, like a two-part design and attachment features that help keep the implant especially stable. As detailed in our earlier blog post, zirconia implants still have their pros and cons, but for patients who are allergic to titanium but still want the benefits of an implant, they can be a good choice.
Bridges: Another Option for Tooth Replacement
Of course, implants are not the only solution for replacing a lost tooth. For decades, people have relied on bridges to literally “bridge” the gap left by a missing tooth, and for many patients, a bridge can be a great option. A traditional bridge (shown below) features one or more artificial teeth or"pontics" supported by the teeth on either side of the gap. Before the bridge is placed, these teeth need toreceive crowns to hold thetooth and allow normal forces on the artificial tooth to be supported by the neighboringteeth. That means a considerable amount of tooth material will need to be removed from these teeth to “make room” for the crowns. Once the material is removed, these teeth are at increased risks of complications such as root canals, fractures, and recurrent decay. However, bridges have a long and successful track record in helping restore function and aesthetics following tooth loss, and they can be a great choice for many patients.
A Maryland bridge features a slightly different design and attachment process that eliminates the need to remove surface material from the healthy neighboring teeth. Instead, the bridge is secured in place with an adhesiveresin to attach the bridge to one or both teeth on either side, often times with little to no tooth removal. This eliminates some of the risks of traditional bridges. Maryland bridges are an especially good option of replacing front teeth in the “aesthetic zone.” However, the bonding application that’s used means these bridges are not nearly asdurable as a traditional bridge, and that means the forces exerted during biting and chewing can lead to fractures ordebondingof the artificial tooth (pontic). These bridges, while an attractive option for some, are really only meant for aesthetic enhancement, and not as a functional replacement for a missing tooth.
Partial Dentures
Another time-tested option for replacing one or more missing teeth, a partial denture is removable and rests on your gums in the gap left by the missing tooth or teeth. Partial dentures are usually less expensive than other options, but many people don’t want a device that’s removable or poses a risk of slipping, nor do they want to have to remove the denture at night while they’re sleeping. What’s more, the partial denture has a rigid metal framework for strength and stabilitywhich unfortunately can often be seen in certain areas and may be intolerable by some patients due to allergy or sensitivity. There are some options for all-plastic dentures, butthey tend not to be as functional as a traditional denture with a metal framework. No matter which option you select, it’s estimated that removable partial dentures haveat most25% of the function of a real tooth, implant, or bridge.
Titanium Allergy: The Bottom Line
Allergic reactions to titanium are very rare, but they are a possibility. Before having an implant procedure, it’s a good idea to consider the MELISA test to check for a titanium allergy so you can avoid the resulting side effects. And if you are allergic to titanium or if you suspect you may be, schedule a visit to discuss your other options that can help you restore your teeth and maintain your healthy-looking smile. Call our office at310-278-0440and schedule a consultation today.
References:
1. Fage et. al.Contact Dermatitis. 2016 Jun;74(6):323-45.
2. Muller et. al.Neuro Endocrinol Lett.2006 Dec;27 Suppl 1:31-5.
FAQs
How do you know if you are allergic to titanium dental implants? ›
Some of the common symptoms of a titanium allergy to a dental implant include hives and bumps in the mouth, dry patches of gum tissue, inflammation of the gums around the implant, and sores or swelling in the oral soft tissues. It's possible to detect a titanium allergy ahead of time with a MELISA test.
What are the chances of being allergic to titanium? ›Titanium allergies are rare, occurring in about 0.6% of the population, according to one study. That means as many as 1.8 million people in the U.S. may be allergic to titanium to some degree. Other studies suggest the allergic reaction or hypersensitivity to titanium could be much higher.
Can your body reject a titanium implant? ›However, some people can be intolerant to the metal and can experience hyper-sensitization or an allergic reaction with titanium implants. Titanium allergy is rare, though – research shows that an average of less than 1% of people who undergo a dental implant surgery report a titanium allergy.
How do you know if you're allergic to titanium? ›Seminal studies cited by the International Journal of Implant Dentistry report that titanium allergy symptoms include: Erythema (skin redness, in this case, in the tissues around the implant) Urticaria (hives that may be seen on the skin or gum surface) Eczema (itchy inflammation of the skin or gum tissue)
How do I know if my body is rejecting my dental implant? ›Some signs of allergic reactions include loss of taste, swelling around the gums, and a tingling sensation. Sudden allergic reactions are a sign of dental implant failure because they indicate that your body is rejecting the implant.
Can someone be allergic to titanium implants? ›One of the causes of implant failure can be attributed to allergic reactions to titanium. There have been reports of hypersensitive reactions such as erythema, urticaria, eczema, swelling, pain, necrosis, and bone loss due to titanium dental implants [15, 67, 68].
Can titanium implants make you sick? ›One of the causes of implant failure can be attributed to allergic reactions to titanium. There have been reports of hypersensitive reactions such as erythema, urticaria, eczema, swelling, pain, necrosis, and bone loss due to titanium dental implants [15, 67, 68].
Can your body reject teeth implants? ›According to the International Congress of Oral Implantologists it is rare that your body will reject your dental implants. However, this does not mean that your dental implant will not fail. A successful dental implant is one that is placed in healthy bone and is properly cared for after the surgery takes place.
Do titanium implants cause toxicity? ›It is not considered a toxic metal but it is a heavy metal and it does have serious negative health effects. Titanium has the ability to affect lung function causing lung diseases such as pleural disease, it can cause chest pain with tightness, breathing difficulties, coughing, irritation of the skin or eyes.
Can titanium implants cause autoimmune disease? ›Multiple investigators have found that titanium implants can induce inflammation in the surrounding tissue over time, leading to the expression of certain mediators known to cause local and systemic health problems. While acute disease is unavoidable, chronic diseases (cancer, autoimmune diseases, etc.)
Is there nickel in titanium dental implants? ›
While titanium is considered to be “nickel free,” and titanium alloy is commonly used as an alternative to stainless steel alloys for patients who may have nickel sensitivity, it is possible that trace amounts of impurities including nickel could be contained within these materials.
Can dental implants cause neurological problems? ›Painful post-traumatic trigeminal neuropathy (PTTN) is a known complication of dental implant therapy. Besides cases resulting of nerve damage during surgery or implant placement, some patients report delayed neuropathic-like symptoms only after implant loading i.e. crown placement.
What metals are in titanium dental implants? ›The most commonly used Ti-alloy in dental implant [7, 32] is Ti–6Al–4V, which is also known as Grade V titanium alloy, composed of 6 and 4% of aluminium and vanadium, respectively, together with addition of maximum 0.25% of iron and 0.2% of oxygen. The remaining of the alloy is titanium.
What happens when your body rejects a metal implant? ›The clinical presentation of patients with metal implant reactions is often nonspecific. Patients can present with localized dermatitis or rashes but also with systemic eczematous dermatitis. Swelling, pain, draining sinuses, and inflammation at the implant site may mimic infection.
Can you be allergic to the metal in dental implants? ›Implants rarely trigger metal allergies, even in people with known sensitivities. But if a reaction does occur, removal or replacement of the implants with a different titanium alloy typically provides relief from any symptoms.
Can your body reject titanium screws? ›Some of the side effects of having metal in the body include: Corrosion: Titanium is relatively corrosion resistant. However, given enough time within the human body, even titanium may eventually corrode and require removal. Leaching: Ions from the titanium can leach away from the surgical site to nearby tissues.
Why am I not suitable for dental implants? ›If they have poor oral health with their natural teeth, it's not likely to improve with implants. Poor oral health is primarily related to the lack of oral hygiene. Someone who doesn't brush regularly and allows their teeth and gums to decay without action are not ideal candidates.
How often do dental implants reject? ›It should be noted that the success of dental implants is around 97%, which is high. But it does mean that there is a chance that it will fail or be rejected 3% of the time.
How do you test for titanium? ›Testing by CLIA approved lab: LabCorp or Quest Diagnostics
A blood test for titanium measures the amount of titanium in the blood typically associated with industrial exposure or medical procedures. Specifically titanium ( along with chromium and /or cobalt) are often used in artificial joints.
Observations. An elderly patient who underwent dental implantation to the zygomatic bone was hospitalized in the ophthalmology department with impaired abduction of her right eye, also evident on ocular examination. Head computed tomography demonstrated damage to the lateral rectus and to the inferior oblique muscles.
How long does titanium stay in system? ›
When each titanium implant enters the body, it can last up to 20 years. Dental titanium and dental implants can stay in place for even longer than 20 years without any change in quality.
How safe are titanium dental implants? ›Overall, titanium implant posts are completely safe for the majority of patients. While it is important to be aware of the risks and discuss them with your dentist, there is little reason to be afraid of the titanium material used in dental implant posts.
Can dental implants cause autoimmune? ›Some research suggests that metal medical and dental implants may cause an autoimmune reaction in people with metal allergies and other genetic predispositions. Some of the diseases researched in connection to metal devices include: Multiple sclerosis. Systemic lupus erythematosus (Lupus).
How do you know if your body is rejecting screws? ›...
Symptoms and Complications
- blistering of the skin.
- chronic fatigue.
- chronic inflammation.
- cognitive impairment.
- depression.
- fibromyalgia.
- hives.
- joint pain.
Fever, Redness, and Swelling
Like pain, a bit of swelling around the surgery site is normal after getting dental implants. It should go down after the first few days, though. Increased swelling and redness, especially when accompanied, by fever, is a symptom of infection.
- #1 Misalignment of The Implant: ...
- #2 Poorly Taken Impressions. ...
- #3 Peri-Implantitis And Other Infections. ...
- #4 Failed Osseointegration. ...
- #5 Nerve Damage. ...
- #6 Failure of The Implant Itself. ...
- #7 Foreign body rejection and Allergic reaction.
FAQ about Zirconia vs Titanium Implants
Titanium is stronger and more durable than zirconia, but zirconia implants are more biocompatible with the human body. Titanium implants have a success rate of up to 95%, while zirconia is less than that.
► Titanium Dioxide may be a CARCINOGEN in humans. There may be no safe level of exposure to a carcinogen, so all contact should be reduced to the lowest possible level.
What are 5 interesting facts about titanium? ›- #1) It's Twice as Strong as Aluminum. ...
- #2) It's Naturally Resistant to Corrosion. ...
- #3) It Doesn't Occur Naturally. ...
- #4) It's Used for Medical Implants. ...
- #5) Only 0.63% of the Earth's Crust Is Titanium. ...
- #6) It Has a High Melting Point.
- Heartburn Medications. Proton pump inhibitors (PPIs) such as Pantoloc and Omeprazole are commonly prescribed for patients suffering frequent heartburn. ...
- Anti-Depressants. ...
- Bisphosphonates. ...
- NSAIDS. ...
- Antibiotics. ...
- Beta Blockers.
How does titanium affect the body? ›
Safe in the body
Titanium is considered the most biocompatible metal – not harmful or toxic to living tissue – due to its resistance to corrosion from bodily fluids. This ability to withstand the harsh bodily environment is a result of the protective oxide film that forms naturally in the presence of oxygen.
But occasionally something will go wrong and patients will experience dental implant problems years later. While it doesn't happen often, it is a possibility. These issues can turn into major sources of stress for those patients who do experience it.
How many people are allergic to dental implants? ›Conclusions: Ti allergy can be detected in dental implant patients, even though its estimated prevalence is low (0.6%). A significantly higher risk of positive allergic reaction was found in patients showing post-op allergy compatible response (ACRG), in which cases allergy tests could be recommended.
What are the symptoms of a nickel allergy? ›- Rash or bumps on the skin.
- Itching, which may be severe.
- Redness or changes in skin color.
- Dry patches of skin that may resemble a burn.
- Blisters and draining fluid in severe cases.
Nickel allotment in orthodontic alloys varies from 8% in stainless steel to 50% in nickel-titanium (NiTi) alloy [1].
What happens if an implant hits a nerve? ›If the implant touches the nerve, it can result in facial pain, numbness, and other troublesome symptoms. If it is likely that the implant will touch the nerve, then the oral surgeon may recommend moving the nerve. A bone graft might also be recommended to build up the jawbone before it receives the implants.
Can titanium implants cause depression? ›Some of the patients who receive implants develop severe chemical sensitivity and chronic fatigue as well as autoimmune diseases, headaches, anxiety/depression, cognitive dysfunction, hormone imbalances, thyroid disease, arrhythmias, and chronic infections.
How common is nerve damage after dental implant? ›Although rare, there is still a possibility that they may occur. These risks are usually minor and easily treated. They include infection, injury to surrounding teeth or blood vessels, sinus problems and nerve damage. Every year, around 1% of the dental implant surgeries result in nerve injuries.
How do you know if your body is rejecting surgical hardware? ›Some doctors offer a test called MELISA, which can identify a metal reaction before implant surgery. It is a blood test that looks at the white blood cell reaction when exposed to various metals.
What grade of titanium is used in dental implants? ›These days, the primary materials used for implant fixtures and abutments is commercially pure titanium, grade 2 and grade 4, the screw is usually made from a titanium alloy classified as titanium grade 5 (Ti-6Al-4V). Titanium grade 4 has the highest mechanical strength of all unalloyed Ti.
Can I have an MRI after dental implants? ›
Are dental implants safe in MRI scanners? When seeking implant dentistry from James A. Burden, D.D.S., many patients ask if dental implants will interfere with other medical treatment that requires MRIs. Fortunately, MRIs are completely safe to perform on patients with dental implants.
Can you test for titanium allergy? ›Titanium Allergy Symptoms & Tests
It's possible to detect a titanium allergy ahead of time with a MELISA test. This type of blood test isolates your white blood cells, exposes them to titanium and measures the immune response to titanium.
Slight oozing of blood at the site of the implant can last for up to 72 hours. Forming blood clots is vital to the successful healing of your implants, as they protect the nerves endings in the bone. Disturbing these blood clots can lead to dry socket and excessive bleeding.
How do you know if you have a metal allergy? ›The result: redness, itching, swelling or a rash, with skin blistering or scaling at the site. The symptoms of a metal allergy range from mild to severe. Each time you're re-exposed to the offending metal, your skin reacts in the same way.
What does an allergic reaction to titanium look like? ›Clinical Characteristics of Hypersensitivity to Titanium. Researchers have described various clinical manifestations in patients with allergies to titanium including episodes of hives, eczema, edema, reddening, and itching of the skin or mucosa, which may be localized, or generalized.
What are the symptoms of titanium poisoning? ›Titanium toxicity can elicit a number of symptoms, including fatigue, headaches, blurring of vision, respiratory inflammation, lymphedema, and hyperpigmentation of the nails and skin [[12], [13], [14]].
What are the side effects of titanium implants? ›One of the causes of implant failure can be attributed to allergic reactions to titanium. There have been reports of hypersensitive reactions such as erythema, urticaria, eczema, swelling, pain, necrosis, and bone loss due to titanium dental implants [15, 67, 68].
Is my dental implant making me sick? ›Dental implants are generally safe and do not cause illness in most cases. However, titanium implants can make you sick if you are allergic to the metal. Though only 0.6% of the population has a titanium allergy, it can impact your health and wellness, including your dental implant's success.
Can someone be allergic to dental implant? ›Although titanium is the preferred choice for dental implants as it is an inert material, if used in oral implants, it may encourage toxic or allergic type I or IV reactions.
What happens when your body rejects an implant? ›Redness, swelling, inflammation, and bleeding around the implantation site is a bad sign after the initial few days. Infections can and do occur—especially in smokers, people with an autoimmune disease or diabetes, and those with poor oral hygiene.
Is there a blood test for titanium allergy? ›
Blood based testing may give an more accurate measurement of titanium reactions than patch testing. Titanium particles are too large to penetrate the skin and the relationship between skin sensitivity and systemic hypersensitivity is ill-defined.
How safe are titanium dental implants? ›Overall, titanium implant posts are completely safe for the majority of patients. While it is important to be aware of the risks and discuss them with your dentist, there is little reason to be afraid of the titanium material used in dental implant posts.
How long does titanium stay in system? ›When each titanium implant enters the body, it can last up to 20 years. Dental titanium and dental implants can stay in place for even longer than 20 years without any change in quality.
Who should not get an implant? ›The Very Elderly (with some exceptions)
However, in general, implant dentists, oral surgeons, and periodontists will hesitate before recommending implants for patients over the age of 85. The very elderly tend to have more chronic illnesses that could interfere with the healing process.
If they have poor oral health with their natural teeth, it's not likely to improve with implants. Poor oral health is primarily related to the lack of oral hygiene. Someone who doesn't brush regularly and allows their teeth and gums to decay without action are not ideal candidates.
What medications interfere with dental implants? ›- Heartburn Medications. Proton pump inhibitors (PPIs) such as Pantoloc and Omeprazole are commonly prescribed for patients suffering frequent heartburn. ...
- Anti-Depressants. ...
- Bisphosphonates. ...
- NSAIDS. ...
- Antibiotics. ...
- Beta Blockers.
Conclusions: Ti allergy can be detected in dental implant patients, even though its estimated prevalence is low (0.6%). A significantly higher risk of positive allergic reaction was found in patients showing post-op allergy compatible response (ACRG), in which cases allergy tests could be recommended.
Can titanium implants cause inflammation? ›Multiple investigators have found that titanium implants can induce inflammation in the surrounding tissue over time, leading to the expression of certain mediators known to cause local and systemic health problems. While acute disease is unavoidable, chronic diseases (cancer, autoimmune diseases, etc.)
Is there nickel in titanium dental implants? ›While titanium is considered to be “nickel free,” and titanium alloy is commonly used as an alternative to stainless steel alloys for patients who may have nickel sensitivity, it is possible that trace amounts of impurities including nickel could be contained within these materials.
How does the body react to titanium? ›Safe in the body
Titanium is considered the most biocompatible metal – not harmful or toxic to living tissue – due to its resistance to corrosion from bodily fluids. This ability to withstand the harsh bodily environment is a result of the protective oxide film that forms naturally in the presence of oxygen.
Can dental implants cause neurological problems? ›
Painful post-traumatic trigeminal neuropathy (PTTN) is a known complication of dental implant therapy. Besides cases resulting of nerve damage during surgery or implant placement, some patients report delayed neuropathic-like symptoms only after implant loading i.e. crown placement.
Can your mouth reject a tooth implant? ›Late Dental Implant Rejection
It's typically a result of negligence, such as inadequate home care, dental hygiene, or postoperative trauma. Furthermore, dental implants may also be rejected due to misaligned teeth. Smoking may also result in dental implant rejection, though this is a new area of research.