Dog Sedatives: When and How to Use Them | Bond Vet (2022)

One of the things we love about dogs is their natural joy and playfulness. However, sometimes dogs experience fear, anxiety, and apprehension, just like humans.

Sedatives, training/behavior modification, and natural remedies are some of the tools available to help dogs with fear or stress.

Below, we’ll discuss ways to use sedatives safely and effectively in dogs…

When Do Dogs Need Sedatives?

Some pups go their whole lives without needing a sedative. Other pets suffer from long-term anxiety issues, such as separation anxiety, to the point where their safety and quality of life are greatly impacted. Many pups fall somewhere between these two extremes.

There are certain situations in which a reasonable amount of anxiety is expected, such as during a vet visit or when a new pet is adopted into the home. And some dogs experience short-term but intense anxiety during travel, grooming, toenail trims, or storms.

If a dog’s anxiety is frequent/long-term, severe, or elevated to the point where safety becomes a concern, they’d likely benefit from sedation.

How Do I Know If My Dog Is Anxious?

Some symptoms of fear, nervousness, or anxiety in dogs are obvious, while others are subtle. Some signs to watch for include:

  • Attempts to escape. This could mean anything from turning away at the door of the vet hospital to full-blown panic and destructive behaviors.
  • Ears pulled back.
  • Crouching or making themselves as small as possible.
  • Tail tucked between the legs.
  • “Whale eyes,” which means eyes that are open very wide. The whites of the eyes may be more prominent than usual.
  • Panting.
  • Pacing.
  • Trembling.
  • Tense muscles.
  • Bathroom accidents or anal gland release.
  • Barking excessively.
  • Sometimes, growling, showing teeth, or other signs of aggression, as aggressive behaviors are often rooted in fear or anxiety in an otherwise friendly dog.

Affected dogs may show just 1-2 symptoms or several. A pup’s symptoms can help guide diagnosis and treatment. So try to observe as much as possible.

Since some of the above symptoms can also indicate a medical condition, your dog’s veterinarian may recommend diagnostic testing such as blood work prior to using a sedative.

(Video) Veterinary Tranquilizers and Sedatives (VETERINARY TECHNICIAN EDUCATION)

How Is Anxiety In Dogs Treated?

Behavior modification (training a dog to be less fearful and respond to stressful stimuli in healthier ways) is always indicated for dogs with anxiety.

Behavioral modification and medications often work well together. Medications allow a dog to be calm enough so that training is effective. Meanwhile, training addresses the root cause, which may allow a dog to eventually discontinue their anxiety medications (or at least use them less often or at a lower dose).

Behavior modification is crucial for separation anxiety and other long-term issues. But it can also help in short-term situations.

For example, if a pup is nervous about grooming visits, it may help to briefly stop by the groomer’s office and give the dog a treat. When this is repeated over time, a dog may grow to think of the groomer’s office as a fun place rather than a scary place. This is actually why we install treat bars at the front of each of our clinics and encourage our clinics to stop by for a treat — we want the pups to associate us with something enjoyable.

Behavior modification done properly can change a dog and pet parent’s life for the better. But, done improperly, it can reinforce anxious behaviors.

Therefore, behavior modification should always be done under the guidance of a professional — your veterinarian, a veterinary behaviorist, or a dog trainer with a lot of knowledge in experience in anxiety issues.

What Are Some Natural Remedies for Dog Anxiety?

For dogs with mild anxiety, a vet may recommend starting with these therapies prior to prescribing a sedative or anxiety medication:

  • Training and behavior modification, as described above.
  • Supplements, such as L-theanine, melatonin, Zylkene (hydrolyzed milk protein), or other calming supplements formulated for dogs.
  • Pheromone products (DAP or dog appeasing pheromone), which emit calming dog scent signals.
  • A Thundershirt or other body wrap, which can provide comfort by mimicking swaddling.

Always check with your vet before giving any new medication or supplement to make sure it’s safe for your pup and won’t interact with any medications they are already taking.

(Video) The Anaesthesia Process at Davies Veterinary Specialists

Which Sedatives Are Used for Dogs?

Each pup has unique needs. If a dog tranquilizer or sedative is needed, a vet will consider factors such as how severe a dog’s symptoms are, how long the anxiety has been present, a dog’s medical history, and whether a dog is taking any medications or supplements that could interact with a sedative.

Additionally, a vet will consider all the effects a medication may have on a dog:

  • Some medications make a dog feel sleepy rather than relieving anxiety. These medications may help with short-term situations (such as during a yearly vet visit or for promoting rest in a dog who’s recovering from knee surgery), but might not be a good choice for a dog with severe anxiety.
  • Tranquilizers are medications that have a calming or anti-anxiety effect, but don’t necessarily cause sedation or drowsiness (although some drugs may cause both).
  • Some medications deliver pain relief, while others do not. Pain relief may be beneficial for older, arthritic dogs who tense their muscles when they’re nervous and therefore get sore after a car ride or grooming visit, for example.

With all this in mind, below are some of the most commonly used dog sedatives.


Benadryl (Diphenhydramine) is not technically a sedative. It’s an antihistamine that’s commonly used for relieving allergy symptoms. However, sedation is a very common side effect.

Benadryl is an over-the-counter medication with a good safety margin. However, it’s still important to check with your vet for the right dose and formulation (note: diphenhydramine should be the only active ingredient; don’t use Benadryl with decongestants or other combination products).

Benadryl may be a good dog sedative for car travel, as it also helps with mild car sickness.

Dry mouth or an increased heart rate are fairly common side effects. Rarely, some dogs will have an atypical response and be excitable rather than sedate.


Acepromazine causes sedation. It’s commonly given as an injection as part of anesthesia (one of a combination of drugs) for surgery.

(Video) How can I sedate my dog for grooming at home?

The drug may also be sent home as an oral medication and given to a dog 20-60 minutes before events like grooming, a vet visit, or car travel. Since the medication doesn’t provide much anxiety relief, acepromazine tablets alone might not be enough for a severely stressed, fearful, or aggressive pet (i.e. not the best option for storm/firework phobias or chronic anxieties).

A common side effect of acepromazine is low blood pressure, so the drug is often avoided in dogs with certain medical conditions like heart problems.


Gabapentin is a medication that can be used for several purposes, including seizure control, anxiety relief, sedation, and pain management. It’s a common dog sedative for grooming, travel, vet visits, and other short-term events.

Gabapentin is generally considered safe in healthy pets, with minimal side effects.


Trazodone can both sedate a dog and relieve anxiety. This is a good dog sedative for grooming, veterinary visits, thunderstorms/fireworks, and other short-term stressful events.

Side effects include low blood pressure, so trazodone may be used cautiously or avoided in patients with certain health conditions.

Benzodiazepines (Valium, Xanax, Etc.)

These drugs help with dogs with anxiety during stressful times (thunderstorms, vet visits, grooming, travel, or fireworks), but they usually don’t have strong sedative effects.

Benzodiazepines are generally considered safe, but may be avoided in dogs with certain underlying health conditions. Additionally, in some dogs, they may cause excitement rather than calmness.

(Video) Dogs On Prozac | Veterinarian Explains All You Need To Know

Drugs for Long-term Anxiety Issues

Some dogs, such as those with separation anxiety or severe fear of thunderstorms, may need to take daily medications for a longer period of time. Common medication categories include selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants. Popular options include fluoxetine, clomipramine, and amitriptyline.

Side effects vary, but common ones include stomach upset, heart rate changes, sedation, or excitability. These drugs must be avoided or used cautiously in dogs with certain underlying health conditions.

Injectable Sedation

For some pups, oral medication doesn’t provide enough sedation or anxiety relief. These pets may need injectable sedation administered by a veterinarian during a veterinary checkup, toenail trim, x-rays, or other procedures.

Injectable drugs at a veterinarian’s office are typically stronger than oral medications that are sent home, and thus only administered by veterinary professionals who are trained and prepared to monitor a pet to ensure their heart rate, breathing, and temperature all remain normal during sedation.

What Else Should I Know About Sedatives and Dogs?

It’s important to understand that sedating a dog often requires trial and error to find the best medication and dose, since each dog may respond to sedation differently.

Also, many sedatives can be “overridden” by stress and excitement. So even if a pup had a great response to sedation on one occasion, they may have a different response if they’re more worked up the next time.

To combat this issue, keep a sedated dog as calm as possible. Talk in a quiet and soothing voice, avoid loud noises, and provide a dark, quiet place to rest.

Below are some additional important tips for sedating a dog.

(Video) Natural Sedatives for Travelling With Your Dog or Cat

  • Many vets recommend a “trial run” for short-term sedatives. For example, if using a dog sedative for car travel, give your pup a dose at home before the big travel day to make sure the medication works the way you want it to.
  • Certain sedatives affect a dog’s ability to regulate their body temperature and may make accidents more likely (i.e. dogs should avoid stairs while sedated). Be sure to monitor your pup until they’re more awake, or as advised by your vet.
  • Veterinarians may use a combination of two sedatives together. Often, this achieves great sedation or tranquilization while reducing the risk of side effects.
  • However, some drugs are not safe to combine (in particular, more than one SSRI should not be used together), so don’t try to do combinations without your vet’s recommendation.
  • Many airlines don’t allow sedatives during travel, due to safety risks. This is especially true for pets flying in cargo who can’t be monitored, and for short-nosed breeds who are more prone to respiratory distress and may have more difficulty regulating their body temperature.

As you can see, dog sedatives are not one-size-fits-all. But after consulting with a veterinarian, most pet parents can find an option that works well for keeping their pup relaxed, happy, and safe.

Could your dog benefit from sedation? Schedule a consultation with one of our caring veterinarians to learn more.


When should I give my dog a sedative? ›

Acepromazine. Acepromazine causes sedation. It's commonly given as an injection as part of anesthesia (one of a combination of drugs) for surgery. The drug may also be sent home as an oral medication and given to a dog 20-60 minutes before events like grooming, a vet visit, or car travel.

How do you give a dog a sedative? ›

Give your dog melatonin for a natural, over-the-counter option. This natural supplement that many humans take to help them sleep can be helpful for sedating dogs as well. If your dog weighs less than 5 kg (11 lb), give it 1 mg of melatonin. If your dog weighs 5–15 kg (11–33 lb), give it 1.5 mg.

What do vets use for sedation in dogs? ›

Acepromazine maleate (brand names and alternative names: acetylpromazine, ACE, ACP, PromAce®) is a sedative/tranquilizer used as a pre-anesthetic and for chemical restraint in dogs and cats.

Can I give my dog a sedative before going to the vet? ›

Sedatives are not something to be scared of or worried about. There is nothing wrong with giving, or needing to offer, a sedative to your beloved pet. It makes any vet visit more comfortable and less stressful for you, your pet, and the whole veterinary team.

How long do dog sedatives take to kick in? ›

A sedative allows your dog to relax properly. This makes the entire process as easy for them as falling asleep. The sedative can take 5-10 minutes to take effect, depending on the type of medicine and your dog's size.

How long does a sedative last on a dog? ›

Many dogs are sleepy or tired for twelve to twenty-four hours after anesthesia.

How do vets sedate aggressive dogs? ›

The combination of gabapentin and acepromazine is often very effective in the aggressive and/or fearful patient, allowing one to safely muzzle, place an E-collar, or administer additional IM sedation without causing large undue stress to the dog or hospital staff.

How can I help my dog pass away peacefully? ›

Comforting a Dying Dog
  1. Stay Close to Them. Many dogs will seek comfort during this time and may desire more attention and care. ...
  2. Don't Introduce Your Dog to New People or Places. ...
  3. Maintain Normal Activities as Long as Your Dog Is Able. ...
  4. Talk to Your Vet If Medication Is Needed.
Aug 16, 2018

Can dogs drink water before sedation? ›

The most important thing you can do the morning of your dog's surgery is make sure he does not have access to food or water. Eating and drinking could cause your dog to aspirate during anesthesia, which is potentially life-threatening.

What to expect after a dog is sedated? ›

Home Care Advice After Anaesthesia or Sedation

Your pet may still be a little bit drowsy after he/she goes home with you. There may also be some irritability or incoordination during this initial 24-hour period. The shaved area on your pet's front or back legs is the IV injection and/or IV catheter site.

What are the side effects of sedation in dogs? ›

Anesthesia can cause nausea and may result in vomiting. A little bit of vomiting for a few days after the procedure is typically nothing to worry about (unless you see other warning signs, such as blood in vomit). Loss of appetite may also occur.

Can dogs overdose on sedatives? ›

Overdose will cause excessive sedation, slow respiratory and heart rate, pale gums, unsteady gait, poor coordination, and inability to stand. It also may cause sudden collapse, unconsciousness, seizures, and death. Oral overdose should be treated by emptying the stomach along with monitoring and other supportive care.

How do I take my fearful dog to the vet? ›

How to Help Your Dog Be Less Fearful of the Veterinarian
  1. Make sure your puppy or dog likes or at least accepts being touched. ...
  2. Take your dog to the veterinarian but not for a procedure. ...
  3. Try to stay with your dog as much as possible for procedures. ...
  4. Ask the vet techs get a non slip mat for the floor or table.

How much do vets charge to sedate a dog? ›

Breakdown: Dog Sedation Costs. On average, vets charge $50-$75 to sedate a small dog and $100-$200 to sedate a large dog. Sedation costs are dependent on the animal's weight, which is why the cost can vary so much. Costs also vary based on the type of sedative used.

Are dogs aware when sedated? ›

If your pet has been sedated in advance, then they are usually not aware of anything. Before the vet gives the injection, they will usually ask you if you are ready, and then if you wish to, you can usually hold your pet's head, paw or body in the final moments as he or she passes away.

Do dogs cry when euthanized? ›

A: During the euthanasia process, some pets may cry, whine, or whimper. They may also move in unusual manners, such as paddling their legs, weaving their heads, or stumbling.

Why is my dog whining after sedation? ›

Some pets will also vocalize or whine as the last remaining sedative or anesthetic medications are removed from their systems, or in response to the prescribed pain medication. If crying or whining is mild and intermittent, you may simply monitor the situation. If vocalization persists, please call us for advice.

How do you heavily sedate a dog? ›

The drugs used to sedate a dog are very effective, so they require a prescription from a veterinarian and can only be administered by a veterinarian. The 3 most common drugs used by veterinarians to calm dogs are acepromazine (PromAce®), diazepam (Valium®), and dexmedetomidine (Sileo).

How do vets prepare reactive dogs? ›

At least four weeks before your dog's vet visit, teach your dog that body handling and wearing a muzzle makes hot dogs rain from the sky.
  1. Schedule for the First or Last Appointment. When scheduling a vet visit, ask for the first or last appointment of the day. ...
  2. Wait in Your Car. ...
  3. Exit in the Back.
Feb 1, 2017

How do I know if my dog is suffering? ›

Is my dog in pain?
  1. Show signs of agitation.
  2. Cry out, yelp or growl.
  3. Be sensitive to touch or resent normal handling.
  4. Become grumpy and snap at you.
  5. Be quiet, less active, or hide.
  6. Limp or be reluctant to walk.
  7. Become depressed and stop eating.
  8. Have rapid, shallow breathing and an increased heart rate.
Jun 5, 2017

How do I say goodbye to my dog? ›

How to Say Goodbye to a Pet For The Last Time
  1. Give your pet a day to remember. ...
  2. Spend time reflecting. ...
  3. Plan a burial or cremation. ...
  4. Surround yourself with support. ...
  5. Talk to your vet. ...
  6. Pet loss grief support. ...
  7. Live in the moment. ...
  8. Complete unfinished business.
Jun 28, 2021

What to do if dog dies at home at night? ›

Obtain a blanket, towel, or bed sheet that is large enough to wrap around the body. Also, get a heavy-duty plastic trash bag (double them up if the body is very large or if the bags are thin). Arrange the body on the blanket, towel, or sheet. Place the body on its side in a curled-up position, as if sleeping.

How can I help my dog pass away peacefully? ›

Comforting a Dying Dog
  1. Stay Close to Them. Many dogs will seek comfort during this time and may desire more attention and care. ...
  2. Don't Introduce Your Dog to New People or Places. ...
  3. Maintain Normal Activities as Long as Your Dog Is Able. ...
  4. Talk to Your Vet If Medication Is Needed.
Aug 16, 2018

What are the side effects of sedation in dogs? ›

Anesthesia can cause nausea and may result in vomiting. A little bit of vomiting for a few days after the procedure is typically nothing to worry about (unless you see other warning signs, such as blood in vomit). Loss of appetite may also occur.

How do sedatives affect dogs? ›

Pets that are sedated are in a 'sleepy' state. It makes them physically and mentally relaxed during an investigation which may otherwise be unpleasant. They are unlikely to remember what has happened, much as in humans who have had a procedure under sedation.

What can I give my dog to calm him down for grooming? ›

Acepromazine is an over-the-counter tranquilizer and nervous system depressant administered for nervous dogs. The drug works as a dopamine antagonist. It is used to prevent anxiety during thunderstorms, fireworks, and vet or groomer visits.


1. Will My Dog Wake Up After A Sedated Groom
(My Favorite Groomer)
2. Extremely Aggressive Rottweiler Must Be Sedated To Be Examined | Full Episode | Vet On The Hill
(Bondi Vet)
3. Dog Anxiety Q&A with Dr. Edward Bassingthwaighte - Day 1
(Pet Summits)
4. Sedatives and anesthetics used in horses - Vet students
(Equine Internal Medicine Valentina Vitale)
5. What can I use to sedate my dog?
(Ask About TECH)
6. Vet visits with reactive dogs
(K9 Turbo Training)

Top Articles

Latest Posts

Article information

Author: Sen. Ignacio Ratke

Last Updated: 12/05/2022

Views: 5742

Rating: 4.6 / 5 (56 voted)

Reviews: 87% of readers found this page helpful

Author information

Name: Sen. Ignacio Ratke

Birthday: 1999-05-27

Address: Apt. 171 8116 Bailey Via, Roberthaven, GA 58289

Phone: +2585395768220

Job: Lead Liaison

Hobby: Lockpicking, LARPing, Lego building, Lapidary, Macrame, Book restoration, Bodybuilding

Introduction: My name is Sen. Ignacio Ratke, I am a adventurous, zealous, outstanding, agreeable, precious, excited, gifted person who loves writing and wants to share my knowledge and understanding with you.