Dosing & Treatment| NUEDEXTA® (dextromethorphan HBr and quinidine sulfate)| HCP Site (2023)

Dosing & Treatment| NUEDEXTA® (dextromethorphan HBr and quinidine sulfate)| HCP Site (2)

NUEDEXTA Dosageand Administration

NUEDEXTA is the first and only FDA-approved treatment for Pseudobulbar Affect (PBA). NUEDEXTA is a combination of dextromethorphan HBr (20 mg) and quinidine sulfate (10 mg) in a capsule.1

STARTING DOSE

Days 1-7

1 capsule per day
(1 capsule PO QD)

Dosing & Treatment| NUEDEXTA® (dextromethorphan HBr and quinidine sulfate)| HCP Site (3)

Not actual size.

MAINTENANCE DOSE

Beginning Day 8

2 capsules per day
(1 capsule PO Q12H)

Dosing & Treatment| NUEDEXTA® (dextromethorphan HBr and quinidine sulfate)| HCP Site (4)Dosing & Treatment| NUEDEXTA® (dextromethorphan HBr and quinidine sulfate)| HCP Site (5)

Not actual size.

Titrate to 1 capsule every 12 hours on Day 8. Efficacy beyond Week 1 in the STAR Pivotal trial was achieved with Q12H dosing.2

Following this regimen, patients on NUEDEXTA had a mean 82% reduction in PBA episodes versus 45% on placebo at Week 12 in the STAR Pivotal trial.2

The need for continued treatment should be reassessed periodically as spontaneous improvement of PBA symptoms occurs in some patients.

Specific Populations1

In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

No dose adjustments are required in patients with mild-to-moderate renal or hepatic impairment. NUEDEXTA has not been evaluated in patients with severe renal or hepatic impairment. However, increases in dextromethorphan and/or quinidine levels are likely to be observed.

NUEDEXTA's Drug Classification

NUEDEXTA is a central nervous system (CNS) agent that is categorized in the "Central Nervous System, Other" pharmacologic class in the United States Pharmacopeia and National Formulary (USP-NF).4 NUEDEXTA is not an antipsychotic medication, a psychotropic medication, nor a controlled substance.

Dosing & Treatment| NUEDEXTA® (dextromethorphan HBr and quinidine sulfate)| HCP Site (6)

Script pad is used for illustrative purposes only.

Document your diagnosis of PBAusing ICD-10 code F48.2.3

Pseudobulbar Affect is a separate neurologic diagnosis — and the right diagnosis can lead to the right treatment.

Script pad is used for illustrative purposes only.

This code is intended for reference only. ICD-10-CM codes submitted to the payer must be determined by the provider/physician and accurately describe PBA as the diagnosis for which the patient receives NUEDEXTA as treatment.

NUEDEXTAPharmacology

Dosing & Treatment| NUEDEXTA® (dextromethorphan HBr and quinidine sulfate)| HCP Site (7)

See The Pathophysiology of PBA

Learn how PBA is thought to arise in the brain of a patient with a neurologic condition or brain injury.

Download a transcriptof this video.

Dosing & Treatment| NUEDEXTA® (dextromethorphan HBr and quinidine sulfate)| HCP Site (8)

See The Pharmacology of NUEDEXTA

Watch this video to learn more about the components of NUEDEXTA. The exact mechanism by which NUEDEXTA exerts its therapeutic effects in patients with PBA is unknown.1

Download a transcriptof this video.

To learn more about PBA's mechanism of disease, visit PBA and the Brain.

NUEDEXTA is a combination of 2 well-characterized components1

1

Dextromethorphan HBr (20 mg)1,5

Dosing & Treatment| NUEDEXTA® (dextromethorphan HBr and quinidine sulfate)| HCP Site (9)

An uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and sigma-1 receptor agonist believed to modulate certain neurotransmitter functions

2

Quinidine sulfate (10 mg)—ultra-low dose1,6

Dosing & Treatment| NUEDEXTA® (dextromethorphan HBr and quinidine sulfate)| HCP Site (10)

A CYP2D6 metabolic inhibitor that increases dextromethorphan (DM) bioavailability and prolongs its elimination half-life


NUEDEXTA is believed to modulate certain neurotransmitter functions5

Dextromethorphan is thought to target glutamate signaling in two ways. The exact mechanism by which NUEDEXTA exerts its therapeutic effects in patients with PBA is unknown.1

Dosing & Treatment| NUEDEXTA® (dextromethorphan HBr and quinidine sulfate)| HCP Site (11)

Binding of dextromethorphanto sigma-1 receptors is believed to result in the inhibition of glutamate release.5


Dosing & Treatment| NUEDEXTA® (dextromethorphan HBr and quinidine sulfate)| HCP Site (12)

NMDA is one of the main neurotransmitter receptors for glutamate. Dextromethorphan-NMDA receptor antagonism reduces postsynaptic glutamate signaling.5,7

Co-Pay, Sample & Voucher Requests Dosing & Treatment| NUEDEXTA® (dextromethorphan HBr and quinidine sulfate)| HCP Site (13)

CO-PAY SAVINGS CARD

Share this card to help your patients save on their NUEDEXTA prescription and refills. By enrolling, your commercially insured patients may pay as little as $0 for a 90-day supply, or $20 for a 30-day supply.

Print Co-Pay Savings Card Restrictions apply. Most commercially insured patients pay as little as $0 for a 90-day supply or $20 for a 30-day supply. Benefit cap applies regardless of co-pay amount.

REQUEST SAMPLES OR FREE TRIAL VOUCHERS

Eligible healthcare providers can request a free 10-day sample of NUEDEXTA for appropriate patients, or a 10-day free trial voucher where samples are not accepted.

Request a Sample Request a Free Trial Voucher

MLR-NUE-US-1834-0522

References: 1. NUEDEXTA [package insert]. Aliso Viejo, CA: Avanir Pharmaceuticals, Inc. 2.Data on File. Avanir Pharmaceuticals, Inc. 3.Centers for Disease Control and Prevention (CDC). International Classification of Diseases. Tenth Revision, Clinical Modification (ICD-10-CM). https://www.cdc.gov/nchs/icd/icd10cm.htm. Accessed April 24, 2019. 4.The United States Pharmacopeial Convention (USP). Medicare Model guidelines v7.0. USP website. http://www.usp.org/sites/default/files/usp/document/our-work/healthcare-quality-safety/uspmmg_v7_0_w_exampledrugs_rev170206.pdf. Accessed April 1, 2019. 5.Werling LL, Lauterbach EC, Calef U. Dextromethorphan as a potential neuroprotective agent with unique mechanisms of action. Neurologist. 2007;13(5):272-293. 6.Schadel M, Wu D, Otton SV, Kalow W, Sellers EM. Pharmacokinetics of dextromethorphan and metabolites in humans: influence of the CYP2D6 phenotype and quinidine inhibition. J Clin Psychopharmacol. 1995;15(4):263-269. 7.Pankevich DE, Davis M, Altevogt BM; for the Institute of Medicine Forum on Neuroscience and Nervous System Disorders. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary. Washington, DC: The National Academies Press; 2011.

INDICATION AND USAGE

NUEDEXTA® (dextromethorphan HBr and quinidine sulfate) is indicated for the treatment of pseudobulbar affect (PBA). PBA occurs secondary to a variety of otherwise unrelated neurologic conditions, and is characterized by involuntary, sudden, and frequent episodes of laughing and/or crying. PBA episodes typically occur out of proportion or incongruent to the underlying emotional state. PBA is a specific condition, distinct from other types of emotional lability that may occur in patients with neurologic disease or injury.

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS

Quinidine and Related Drugs: NUEDEXTA contains quinidine, and should not be used concomitantly with other drugs containing quinidine, quinine, or mefloquine.

Hypersensitivity: NUEDEXTA is contraindicated in patients with a history of NUEDEXTA-, quinine-, mefloquine-, or quinidine-induced thrombocytopenia, hepatitis, bone-marrow depression, lupus-like syndrome, or known hypersensitivity to dextromethorphan (eg, rash, hives).

MAOIs: NUEDEXTA is contraindicated in patients taking monoamine oxidase inhibitors (MAOIs), or in patients who have taken MAOIs within the preceding 14 days, due to the risk of serious and possibly fatal drug interactions, including serotonin syndrome. Allow at least 14 days after stopping NUEDEXTA before starting an MAOI.

Cardiovascular: NUEDEXTA is contraindicated in patients with a prolonged QT interval, congenital long QT syndrome, history suggestive of torsades de pointes, heart failure, patients receiving drugs that both prolong QT interval and are metabolized by CYP2D6 (eg, thioridazine and pimozide), patients with complete atrioventricular (AV) block without implanted pacemaker, or at high risk of complete AV block.

WARNINGS AND PRECAUTIONS

Thrombocytopenia and Other Hypersensitivity Reactions: Quinidine can cause immune-mediated thrombocytopenia that can be severe or fatal. Non-specific symptoms, such as lightheadedness, chills, fever, nausea, and vomiting, can precede or occur with thrombocytopenia. NUEDEXTA should be discontinued immediately if thrombocytopenia occurs.

Hepatotoxicity: Hepatitis, including granulomatous hepatitis, has been reported in patients receiving quinidine, generally during the first few weeks of therapy. Discontinue immediately if this occurs.

Cardiac Effects: NUEDEXTA causes dose-dependent QTc prolongation. QT prolongation can cause torsades de pointes–type ventricular tachycardia, with the risk increasing as the degree of prolongation increases. When initiating NUEDEXTA in patients at risk for QT prolongation and torsades de pointes, electrocardiographic (ECG) evaluation of QT interval should be conducted at baseline and 3 to 4 hours after the first dose. Some risk factors include use with CYP3A4 inhibitors or drugs that prolong QT interval, electrolyte abnormalities, bradycardia, or left ventricular hypertrophy or dysfunction. If patients taking NUEDEXTA experience symptoms that could indicate the occurrence of cardiac arrhythmias (eg, syncope or palpitations), NUEDEXTA should be discontinued, and the patient further evaluated.

Concomitant Use of CYP2D6 Substrates: NUEDEXTA inhibits CYP2D6 and may interact with other drugs metabolized by CYP2D6. Adjust dose of CYP2D6 substrates as needed.

Dizziness: NUEDEXTA may cause dizziness. Take precautions to reduce the risk of falls.

Serotonin Syndrome: Use of NUEDEXTA with selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants increases the risk of “serotonin syndrome.”

Anticholinergic Effects of Quinidine: Monitor for worsening in myasthenia gravis.

ADVERSE REACTIONS

The most common adverse reactions (incidence of ≥3% and two-fold greater than placebo) in patients taking NUEDEXTA are diarrhea, dizziness, cough, vomiting, asthenia, peripheral edema, urinary tract infection, influenza, increased gamma-glutamyltransferase, and flatulence.

These are not all the risks for use of NUEDEXTA. Please see Full Prescribing Information.

FAQs

What is dextromethorphan quinidine used for? ›

Dextromethorphan and quinidine combination is used to treat a rare condition called pseudobulbar affect (PBA) or emotional incontinence. PBA is a nervous system disorder that is characterized by uncontrollable, sudden, and frequent episodes of crying or laughing.

How long can you take Nuedexta? ›

Nuedexta is usually taken once per day for 7 days, and then once every 12 hours. Follow your doctor's dosing instructions very carefully. You may take Nuedexta with or without food. Your doctor will need to check your progress on a regular basis.

How do you take quinidine sulfate? ›

Quinidine sulfate tablets are usually is taken every 6 hours. Extended-release quinidine gluconate tablets are usually is taken every 8 to 12 hours. Take quinidine at around the same times every day.

How do you take Nuedexta? ›

How to use Nuedexta. Take this medication by mouth with or without food with a full glass of water (8 ounces/240 milliliters) as directed by your doctor, usually one capsule every 12 hours. Do not lie down for at least 10 minutes after taking this medication.

How often should you take dextromethorphan? ›

Adults and children 12 years of age and older—5 to 15 mg every two to four hours, as needed. Children 6 to 12 years of age—5 to 15 mg every two to six hours, as needed. Children 4 to 6 years of age—5 mg every four hours, as needed.

What drug class is dextromethorphan quinidine? ›

Dextromethorphan is in a class of medications called central nervous system agents. The way it works in the brain to treat PBA is not known. Quinidine is in a class of medications called antiarrhythmics.

Can nuedexta be stopped abruptly? ›

Will I have any withdrawal symptoms if I stop taking Nuedexta? It's not common to have withdrawal symptoms after stopping Nuedexta. Withdrawal symptoms weren't reported in people taking this drug during clinical studies. However, dextromethorphan (a drug contained in Nuedexta) can sometimes be misused.

What does nuedexta do to the brain? ›

Nuedexta's mechanism of action

The exact mechanism of action of the drug is not completely known but it is believed to work by regulating excitatory neurotransmissions through the sigma-1 receptor agonist activity and NMDA receptor antagonist activity. The drug also slows the breakdown of dextromethorphan in the brain.

Why do people take nuedexta? ›

NUEDEXTA is PROVEN. to reduce PBA EPISODES. PBA (Pseudobulbar Affect) is a medical condition that causes involuntary, sudden, and frequent episodes of crying and/or laughing in people living with certain neurologic conditions or brain injury.

What is the route of administration for quinidine? ›

Quinidine (Oral Route, Injection Route, Intramuscular Route)

What are the primary nursing actions required before administering quinidine? ›

Check apical pulse, BP, and cardiac monitor prior to administration of quinidine. Monitor blood pressure, QRS duration, and QT interval frequently for patients receiving quinidine. If QRS widens > 50%, notify physician.

Who should not take quinidine? ›

Quinidine can increase your risk of death. Your risk may be higher if you have structural heart disease. Two analyses of evidence from studies showed that people who were taking quinidine to prevent irregular heart rate had a higher risk of dying than those who didn't take the drug.

What type of medication is nuedexta? ›

Nuedexta is a prescription medicine used to treat the symptoms of Pseudobulbar Affect. Nuedexta may be used alone or with other medications. Nuedexta belongs to a class of drugs called NMDA Antagonists. It is not known if Nuedexta is safe and effective in children.

Is nuedexta used to treat depression? ›

One case report found that Nuedexta had antidepressant effects in a depressed patient with emotional lability [51].

What can replace nuedexta? ›

Alternative Nuedexta treatment options include tricyclic antidepressants, such as Elavil (amitriptyline) and Pamelor (nortriptyline), and selective serotonin reuptake inhibitors (SSRIs), such as Celexa (citalopram), Zoloft (sertraline), and Prozac (fluoxetine).

How much dextromethorphan can you take in 24 hours? ›

The maximum recommended daily dose of DXM is 120 mg; beyond that, intoxication and dangerous side effects begin to appear. A dose of 100-200 mg induces mild stimulation and euphoria. A dose of 200-400 mg leads to stronger euphoria and hallucinations.

When is the best time to take dextromethorphan? ›

How to use Dextromethorphan Hbr Syrup. Take this medication by mouth, usually every 4 to 12 hours as needed or as directed by your doctor. If stomach upset occurs, take with food or milk. Use a medication-measuring device to measure your dose of liquid medication.

Who should avoid dextromethorphan? ›

Dextromethorphan is used to relieve coughs due to colds or influenza (flu). It should not be used for chronic cough that occurs with smoking, asthma, or emphysema or when there is an unusually large amount of mucus or phlegm (flem) with the cough.

Does dextromethorphan HBR increase heart rate? ›

Blood pressure and heart rate

Heart rate was significantly increased at the two highest DXM doses (26 beats/min at the maximum dose) and at the 0.5 mg/70 kg dose of triazolam (10.2 beats/min).

Can you take dextromethorphan HBR with high blood pressure? ›

Some providers may recommend taking dextromethorphan (Robitussin) if you have high blood pressure. However, you want to be careful to avoid the “CF” and “D” varieties of this medication. If you're unsure, check with your provider before taking this medication.

How long does it take for quinidine to work? ›

How Long Does Nuedexta Take to Work? Once ingested, dextromethorphan takes about three to four hours to peak, while quinidine takes about one to two hours. Check with your healthcare provider or pharmacist if you've any questions.

How long does it take for NUEDEXTA to start working? ›

NUEDEXTA is meant to work over time. You should expect to see your best results by about 90 days,* so give it time to work. Taking your medication as prescribed can give you the best chance to start seeing a reduction in episodes.

Does NUEDEXTA help with speech? ›

Nuedexta is FDA approved for the treatment of pseudobulbar affect in ALS patients and anecdotal reports of improvements in speech, salivation or swallowing have been reported.

Is NUEDEXTA a psych med? ›

NUEDEXTA is not an antipsychotic medication, a psychotropic medication, nor a controlled substance.

How does dextromethorphan affect the nervous system? ›

DXM also depresses brain function, particularly the parts of the brain that control breathing and heart function. Taking a lot of DXM causes hallucinations and out-of-body sensations similar to the ones caused by drugs like ketamine and PCP. These effects can last as long as 6 hours.

What drug causes brain cells loss? ›

Which Drugs Kill Brain Cells? Different drugs can have neurotoxic and destructive effects on brain cells. Substances that are associated with neurological damage include but are not limited to alcohol, heroin, amphetamines, marijuana, opioids, inhalants, and cocaine.

Can nuedexta cause serotonin syndrome? ›

When used with SSRIs (such as fluoxetine) or tricyclic antidepressants (such as clomipramine and imipramine), NUEDEXTA may cause “serotonin syndrome”, with changes including altered mental status, hypertension, restlessness, myoclonus, hyperthermia, hyperreflexia, diaphoresis, shivering, and tremor [see Drug ...

When is the best time to take nuedexta? ›

take ONE CAPSULE each morning. on day eight, increase your dose to TWO CAPSULES per day—one in the morning, one in the evening, 12 hours apart. This dose introduces NUEDEXTA to your body. This is your daily dose for the rest of your treatment.

Can quinidine cause heart failure? ›

Quinidine-induced long QT syndrome has resulted in rare cases of torsades de pointes. Myocardial toxicity may present as malignant arrhythmias, increased QRS duration of greater than 50%, high degree AV heart block, or cardiac arrest.

What does nuedexta cost? ›

The cost for Nuedexta oral capsule (20 mg-10 mg) is around $1,510 for a supply of 60 capsules, depending on the pharmacy you visit.
...
Oral Capsule.
QuantityPer unitPrice
60$25.17$1,510.03

What is the medication quinidine used for? ›

Quinine is used to treat malaria caused by Plasmodium falciparum. Plasmodium falciparum is a parasite that gets into the red blood cells in the body and causes malaria. Quinine works by killing the parasite or preventing it from growing.

How do you administer quinine protocol? ›

Child and adult: loading dose: 20 mg/kg administered over 4 hours, then keep the vein open with an infusion of 5% glucose over 4 hours. maintenance dose: 8 hours after the start of the loading dose, 10 mg/kg every 8 hours (alternate quinine over 4 hours and 5% glucose over 4 hours)

How do you administer quinine? ›

Quinine can also be administered via intramuscular injection if intravenous infusions cannot be given: two injections of 10 mg salt/kg quinine dihydrochloride (diluted to 60 mL) should be administered four hours apart. The anterior thigh is preferred over the gluteal region to minimize the risk of sciatic nerve damage.

What are the 5 steps for administering medication? ›

One of the recommendations to reduce medication errors and harm is to use the “five rights”: the right patient, the right drug, the right dose, the right route, and the right time.

What are the 3 checks a nurse should perform when preparing a medication for administration? ›

WHAT ARE THE THREE CHECKS? Checking the: – Name of the person; – Strength and dosage; and – Frequency against the: Medical order; • MAR; AND • Medication container.

Does quinidine increase or decrease heart rate? ›

Quinidine significantly increased the heart rate at rest and at low levels of exercise. Quinidine had no significant effect on the systolic blood pressure response to any work load.

Does dextromethorphan affect the heart? ›

This medicine can cause changes in heart rhythms, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients.

Can dextromethorphan cause heart palpitations? ›

Do not take more than the recommended amount of dextromethorphan. If you experience muscle twitching, tremors, shivering or stiffness, fever, heavy sweating, heart palpitations, restlessness, confusion, agitation, trouble with coordination, or severe diarrhea contact your doctor right away.

Does quinidine slow heart rate? ›

What is this medication? QUINIDINE (KWIN i deen) is an antiarrhythmic drug. It helps make your heart beat regularly. This medicine also helps to slow rapid heartbeats.

Why is quinidine given with dextromethorphan? ›

Dextromethorphan and quinidine combination is used to treat a rare condition called pseudobulbar affect (PBA) or emotional incontinence. PBA is a nervous system disorder that is characterized by uncontrollable, sudden, and frequent episodes of crying or laughing.

What is another name for nuedexta? ›

Nuedexta (dextromethorphan / quinidine) is the first and only medication approved for pseudobulbar affect (PBA), a condition that causes uncontrollable laughing or crying.

What are the 4 types of drugs used to treat disorders? ›

We also have general information about the four main types of psychiatric medication:
  • Antidepressants.
  • Antipsychotics.
  • Sleeping pills and minor tranquillisers.
  • Lithium and other mood stabilisers.

How long can you take NUEDEXTA? ›

Nuedexta is usually taken once per day for 7 days, and then once every 12 hours. Follow your doctor's dosing instructions very carefully. You may take Nuedexta with or without food. Your doctor will need to check your progress on a regular basis.

What is the first line drug for depression? ›

Choosing an antidepressant — For the initial treatment of severe depression, we use serotonin-norepinephrine reuptake inhibitors (SNRIs) or selective serotonin reuptake inhibitors (SSRIs).

What is the main drug to treat depression? ›

Selective serotonin reuptake inhibitors (SSRIs)

SSRIs are the most widely prescribed type of antidepressants. They're usually preferred over other antidepressants, as they cause fewer side effects. An overdose is also less likely to be serious.

Can Nuedexta be stopped abruptly? ›

Will I have any withdrawal symptoms if I stop taking Nuedexta? It's not common to have withdrawal symptoms after stopping Nuedexta. Withdrawal symptoms weren't reported in people taking this drug during clinical studies. However, dextromethorphan (a drug contained in Nuedexta) can sometimes be misused.

What does Nuedexta do to the brain? ›

Nuedexta's mechanism of action

The exact mechanism of action of the drug is not completely known but it is believed to work by regulating excitatory neurotransmissions through the sigma-1 receptor agonist activity and NMDA receptor antagonist activity. The drug also slows the breakdown of dextromethorphan in the brain.

Is quinidine still used? ›

Quinidine is a medication used in the management and treatment of specific arrhythmias and malaria. It comes under the "class 1a antiarrhythmic" class of drugs.

What are the benefits of dextromethorphan? ›

Dextromethorphan is used to temporarily relieve cough caused by the common cold, the flu, or other conditions. Dextromethorphan will relieve a cough but will not treat the cause of the cough or speed recovery. Dextromethorphan is in a class of medications called antitussives.

How does dextromethorphan work in the body? ›

Dextromethorphan and its major metabolite, dextrorphan, also block the NMDA receptor at high doses, which produces effects similar to other dissociative anesthetics such as ketamine, nitrous oxide, and phencyclidine. It was patented in 1949 and approved for medical use in 1953.

What is the effect of quinidine on the heart? ›

Quinidine is a Class 1a antiarrhythmic. It works in the heart to slow down the electrical impulses that make the heart muscle contract and pump blood. During an arrhythmia, heart muscle contractions are irregular. Slowing down the electrical impulses can regulate the heartbeat and stop the arrhythmia.

Does dextromethorphan cause rapid heart beat? ›

DXM can cause increased body temperature, abdominal pain, throwing up (vomiting), irregular heartbeat, increased heart rate, numbness of fingers and toes, high blood pressure, loss of consciousness, seizures, brain damage and death.

What are the dangers of dextromethorphan? ›

DXM might seem safe since it's sold over the counter. But large quantities can cause dangerous side effects, including loss of consciousness, seizures, brain damage, and death. One particularly dangerous side effect of DXM is hyperthermia — extremely high fever.

How fast does dextromethorphan start working? ›

Dextromethorphan (Delsym) starts to work within 15 to 30 minutes after taking it. The full effects of the medication happen about 2 hours after your dose.

How much dextromethorphan is effective? ›

The typical adult dose for cough is 15 to 30 mg taken three to four times daily. The cough- suppressing effects of DXM persist for 5 to 6 hours after ingestion. When taken as directed, side effects are rarely observed.

When should you not take dextromethorphan? ›

You should not use dextromethorphan if you are allergic to it. Ask a doctor or pharmacist if this medicine is safe to use if you have any medical conditions. Dextromethorphan should not be given to a child younger than 12 years old. Ask a doctor before using this medicine if you are pregnant or breast-feeding.

What are the contraindications of quinidine? ›

Quinidine is contraindicated in patients who are known to be allergic to it, or who have developed thrombocytopenic purpura during prior therapy with quinidine or quinine.

Will dextromethorphan raise blood pressure? ›

Can Mucinex DM (guaifenesin / dextromethorphan) raise your blood pressure? High blood pressure isn't a common side effect of Mucinex DM (guaifenesin / dextromethorphan). Neither of the main ingredients should have an effect on blood pressure when taken as recommended on the package.

How much does dextromethorphan increase BP? ›

Blood pressure and heart rate

DXM produced orderly, significant, and dose-related increases in systolic and diastolic blood pressure (20.8 mm Hg, 14.6 mm Hg, respectively at the maximum dose).

Does dextromethorphan lower blood pressure? ›

Low-Dose Dextromethorphan, a NADPH Oxidase Inhibitor, Reduces Blood Pressure and Enhances Vascular Protection in Experimental Hypertension - PMC. The .

Top Articles
Latest Posts
Article information

Author: Manual Maggio

Last Updated: 11/13/2022

Views: 6231

Rating: 4.9 / 5 (49 voted)

Reviews: 80% of readers found this page helpful

Author information

Name: Manual Maggio

Birthday: 1998-01-20

Address: 359 Kelvin Stream, Lake Eldonview, MT 33517-1242

Phone: +577037762465

Job: Product Hospitality Supervisor

Hobby: Gardening, Web surfing, Video gaming, Amateur radio, Flag Football, Reading, Table tennis

Introduction: My name is Manual Maggio, I am a thankful, tender, adventurous, delightful, fantastic, proud, graceful person who loves writing and wants to share my knowledge and understanding with you.