Interstitial cystitis: Another IgG4-related inflammatory disease? (2022)

Interstitial cystitis (IC) is a disease of undetermined etiology and pathogenesis. Inflammation is thought to play a key role in many patients, characteristically with an increase in mast cells within the detrusor muscle of the bladder. We observed that some patients with IC had prominent plasma cells in bladder tissue, which elicited our interest in their possible pathogenic role in patients with IC. A total of 44 cases of IC were collected, including 42 bladder biopsies and 2 cystectomies. Patient age ranged from 18 to 92 years (average age of 49.5 years) and included 7 male and 37 female patients. The histology and immunostains for IgG, IgG4 and tryptase were examined, and the results were correlated with clinical and cystoscopic findings. Four cases showed a significant increase in IgG4-positive plasma cells, with greater than 30 IgG4 plasma cells per high-power field and an IgG4/IgG ratio greater than 0.5. In addition, statistically significant differences were found between IC with IgG4-positive plasma cells vs IgG4-negative cases. The IgG4-positive patients were of older age and had increased severe inflammation and decreased bladder capacity as compared with the IgG4-negative patients. We propose that a subset of patients with IC may have an IgG4-related disease, and further study including serum IgG4 measurement is required to better define this relationship.

Original languageEnglish (US)
Pages (from-to)403-407
Number of pages5
JournalAnnals of Diagnostic Pathology
Volume17
Issue number5
DOIs
StatePublished - Oct 2013
  • Bladder pain syndrome
  • IgG4-related disease
  • Interstitial cystitis
  • Plasma cells
  • Pathology and Forensic Medicine
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Crumley, S., Ge, Y., Zhou, H., Shen, S. S., & Ro, J. Y. (2013). Interstitial cystitis: Another IgG4-related inflammatory disease? Annals of Diagnostic Pathology, 17(5), 403-407. https://doi.org/10.1016/j.anndiagpath.2013.03.004

(Video) Painful Bladder Syndrome (PBS) / Interstitial Cystitis (IC)

Crumley, Suzanne ; Ge, Yimin ; Zhou, Haijun et al. / Interstitial cystitis : Another IgG4-related inflammatory disease?. In: Annals of Diagnostic Pathology. 2013 ; Vol. 17, No. 5. pp. 403-407.

@article{9065d974dc5b44cd853e048d1cbb46a8,

title = "Interstitial cystitis: Another IgG4-related inflammatory disease?",

abstract = "Interstitial cystitis (IC) is a disease of undetermined etiology and pathogenesis. Inflammation is thought to play a key role in many patients, characteristically with an increase in mast cells within the detrusor muscle of the bladder. We observed that some patients with IC had prominent plasma cells in bladder tissue, which elicited our interest in their possible pathogenic role in patients with IC. A total of 44 cases of IC were collected, including 42 bladder biopsies and 2 cystectomies. Patient age ranged from 18 to 92 years (average age of 49.5 years) and included 7 male and 37 female patients. The histology and immunostains for IgG, IgG4 and tryptase were examined, and the results were correlated with clinical and cystoscopic findings. Four cases showed a significant increase in IgG4-positive plasma cells, with greater than 30 IgG4 plasma cells per high-power field and an IgG4/IgG ratio greater than 0.5. In addition, statistically significant differences were found between IC with IgG4-positive plasma cells vs IgG4-negative cases. The IgG4-positive patients were of older age and had increased severe inflammation and decreased bladder capacity as compared with the IgG4-negative patients. We propose that a subset of patients with IC may have an IgG4-related disease, and further study including serum IgG4 measurement is required to better define this relationship.",

keywords = "Bladder pain syndrome, IgG4-related disease, Interstitial cystitis, Plasma cells",

author = "Suzanne Crumley and Yimin Ge and Haijun Zhou and Shen, {Steven S.} and Ro, {Jae Y.}",

note = "Copyright: Copyright 2013 Elsevier B.V., All rights reserved.",

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volume = "17",

(Video) Pelvic Inflammatory Disease - CRASH! Medical Review Series

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Crumley, S, Ge, Y, Zhou, H, Shen, SS & Ro, JY 2013, 'Interstitial cystitis: Another IgG4-related inflammatory disease?', Annals of Diagnostic Pathology, vol. 17, no. 5, pp. 403-407. https://doi.org/10.1016/j.anndiagpath.2013.03.004

Interstitial cystitis : Another IgG4-related inflammatory disease? / Crumley, Suzanne; Ge, Yimin; Zhou, Haijun et al.

In: Annals of Diagnostic Pathology, Vol. 17, No. 5, 10.2013, p. 403-407.

Research output: Contribution to journalArticlepeer-review

TY - JOUR

(Video) Pelvic Inflammatory Disease Part I

T1 - Interstitial cystitis

T2 - Another IgG4-related inflammatory disease?

AU - Crumley, Suzanne

AU - Ge, Yimin

AU - Zhou, Haijun

AU - Shen, Steven S.

AU - Ro, Jae Y.

N1 - Copyright:Copyright 2013 Elsevier B.V., All rights reserved.

PY - 2013/10

Y1 - 2013/10

N2 - Interstitial cystitis (IC) is a disease of undetermined etiology and pathogenesis. Inflammation is thought to play a key role in many patients, characteristically with an increase in mast cells within the detrusor muscle of the bladder. We observed that some patients with IC had prominent plasma cells in bladder tissue, which elicited our interest in their possible pathogenic role in patients with IC. A total of 44 cases of IC were collected, including 42 bladder biopsies and 2 cystectomies. Patient age ranged from 18 to 92 years (average age of 49.5 years) and included 7 male and 37 female patients. The histology and immunostains for IgG, IgG4 and tryptase were examined, and the results were correlated with clinical and cystoscopic findings. Four cases showed a significant increase in IgG4-positive plasma cells, with greater than 30 IgG4 plasma cells per high-power field and an IgG4/IgG ratio greater than 0.5. In addition, statistically significant differences were found between IC with IgG4-positive plasma cells vs IgG4-negative cases. The IgG4-positive patients were of older age and had increased severe inflammation and decreased bladder capacity as compared with the IgG4-negative patients. We propose that a subset of patients with IC may have an IgG4-related disease, and further study including serum IgG4 measurement is required to better define this relationship.

AB - Interstitial cystitis (IC) is a disease of undetermined etiology and pathogenesis. Inflammation is thought to play a key role in many patients, characteristically with an increase in mast cells within the detrusor muscle of the bladder. We observed that some patients with IC had prominent plasma cells in bladder tissue, which elicited our interest in their possible pathogenic role in patients with IC. A total of 44 cases of IC were collected, including 42 bladder biopsies and 2 cystectomies. Patient age ranged from 18 to 92 years (average age of 49.5 years) and included 7 male and 37 female patients. The histology and immunostains for IgG, IgG4 and tryptase were examined, and the results were correlated with clinical and cystoscopic findings. Four cases showed a significant increase in IgG4-positive plasma cells, with greater than 30 IgG4 plasma cells per high-power field and an IgG4/IgG ratio greater than 0.5. In addition, statistically significant differences were found between IC with IgG4-positive plasma cells vs IgG4-negative cases. The IgG4-positive patients were of older age and had increased severe inflammation and decreased bladder capacity as compared with the IgG4-negative patients. We propose that a subset of patients with IC may have an IgG4-related disease, and further study including serum IgG4 measurement is required to better define this relationship.

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KW - IgG4-related disease

KW - Interstitial cystitis

KW - Plasma cells

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(Video) Management of Interstitial Cystitis / Bladder Pain Syndrome - EMPIRE Urology Lecture Series

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VL - 17

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Crumley S, Ge Y, Zhou H, Shen SS, Ro JY. Interstitial cystitis: Another IgG4-related inflammatory disease? Annals of Diagnostic Pathology. 2013 Oct;17(5):403-407. https://doi.org/10.1016/j.anndiagpath.2013.03.004

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