OSPHOS - Dechra Veterinary Products: Veterinary Package Insert (2022)

OSPHOS- clodronate disodium injection, solution
Dechra Veterinary Products

Bisphosphonate

CAUTION: Federal law (USA) restricts this drug to use by or on the order of a licensed veterinarian. For intramuscular use in horses only.

DESCRIPTION: Clodronate disodium is a non-amino, chloro-containing bisphosphonate. Chemically, clodronate disodium is (dichloromethylene) diphosphonic acid disodium salt and is manufactured from the tetrahydrate form.

The structural formula of clodronate disodium is:

OSPHOS - Dechra Veterinary Products: Veterinary Package Insert (1)

Molecular Formula: CH2 Cl2 Na2 O6 P2 Molecular Weight: 288.85

Active substance clodronate disodium tetrahydrate 74.98 mg/mL corresponds to clodronate disodium 60.0 mg/mL. Each mL contains 60 mg clodronate disodium, sodium hydroxide (to adjust pH) and water for injection.

INDICATION: For the control of clinical signs associated with navicular syndrome in horses.

DOSAGE AND ADMINISTRATION: Administer 1.8 mg/kg by intramuscular injection up to a maximum dose of 900 mg per horse. Divide the total volume evenly into three separate injection sites. Discard unused vial contents. OSPHOS is provided in a single use vial and does not contain a preservative.

Clinical improvement is most evident at 2 months post-treatment (see EFFECTIVENESS). Of the horses that responded to treatment with OSPHOS in the field study, 65% maintained their level of improvement through the 6 month evaluation.

If there is no response to initial therapy, the horse should be re-evaluated. For horses that initially respond to OSPHOS but do not maintain their clinical improvement for 6 months, OSPHOS may be re-administered at 3 to 6 month intervals based on recurrence of clinical signs. For horses that respond to OSPHOS and maintain clinical improvement for 6 months, OSPHOS should be re-administered after clinical signs recur.

(Video) Equine Navicular Disease

CONTRAINDICATIONS: Horses with hypersensitivity to clodronate disodium should not receive OSPHOS.

Do not use in horses with impaired renal function or with a history of renal disease.

WARNINGS: Do not use in horses intended for human consumption.

NSAIDs should not be used concurrently with OSPHOS. Concurrent use of NSAIDs with OSPHOS may increase the risk of renal toxicity and acute renal failure.

Human Warnings: Not for human use. Keep this and all drugs out of the reach of children. Consult a physician in case of accidental human exposure.

PRECAUTIONS: OSPHOS has been associated with renal toxicity. Concurrent administration of other potentially nephrotoxic drugs should be approached with caution and renal function should be monitored. Use of bisphosphonates in patients with conditions or diseases affecting renal function is not recommended.

Horses should be well-hydrated prior to and after the administration of OSPHOS due to the potential for adverse renal events. Water intake and urine output should be monitored for 3-5 days post-treatment and any changes from baseline should elicit further evaluation.

As a class, bisphosphonates may be associated with gastrointestinal and renal toxicity. Sensitivity to drug associated adverse reactions varies with the individual patient. Renal and gastrointestinal adverse reactions may be associated with plasma concentrations of the drug. Bisphosphonates are excreted by the kidney; therefore, conditions causing renal impairment may increase plasma bisphosphonate concentrations resulting in an increased risk for adverse reactions.

Administration of bisphosphonates has been associated with abdominal pain (colic), discomfort, and agitation in horses. Clinical signs usually occur shortly after drug administration and may be associated with alterations in intestinal motility. In horses treated with OSPHOS these clinical signs usually began within 2 hours of treatment. Horses should be monitored for at least 2 hours following administration of OSPHOS.

Bisphosphonates affect plasma concentrations of some minerals and electrolytes such as calcium, magnesium and potassium, immediately post-treatment, with effects lasting up to several hours. Caution should be used when administering bisphosphonates to horses with conditions affecting mineral or electrolyte homeostasis (e.g. hyperkalemic periodic paralysis, hypocalcemia, etc.).

The safe use of OSPHOS has not been evaluated in horses less than 4 years of age. The effect of bisphosphonates on the skeleton of growing horses has not been studied; however, bisphosphonates inhibit osteoclast activity which impacts bone turnover and may affect bone growth.

Bisphosphonates should not be used in pregnant or lactating mares, or mares intended for breeding. The safe use of OSPHOS has not been evaluated in breeding horses or pregnant or lactating mares. Bisphosphonates are incorporated into the bone matrix, from where they are gradually released over periods of months to years. The extent of bisphosphonate incorporation into adult bone, and hence, the amount available for release back into the systemic circulation, is directly related to the total dose and duration of bisphosphonate use. Bisphosphonates have been shown to cause fetal developmental abnormalities in laboratory animals. The uptake of bisphosphonates into fetal bone may be greater than into maternal bone creating a possible risk for skeletal or other abnormalities in the fetus. Many drugs, including bisphosphonates, may be excreted in milk and may be absorbed by nursing animals.

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Increased bone fragility has been observed in animals treated with bisphosphonates at high doses or for long periods of time. Bisphosphonates inhibit bone resorption and decrease bone turnover which may lead to an inability to repair microdamage within the bone. In humans, atypical femur fractures have been reported in patients on long term bisphosphonate therapy; however, a causal relationship has not been established.

ADVERSE REACTIONS: One hundred forty-six horses (111 OSPHOS, 35 saline control) of various breeds, 4 to 22 years of age, and weighing 807 to 1,322 pounds were included in the field study safety analysis.

Following treatment on Day 0, 10 horses had clinical signs of discomfort or nervousness, cramping, pawing, and/or colic within 2 hours post-treatment. One horse experiencing colic and hives required treatment with supportive care to resolve clinical signs. In 8 of the 10 horses, 10 to 15 minutes of hand walking resulted in resolution of clinical signs. In one horse, clinical signs resolved without hand walking. Three additional horses experienced lip licking, yawning, and/or head shaking. Adverse reactions occurring within 2 hours post-treatment with OSPHOS or the saline control are summarized in Table 1.

Table 1: Adverse Reactions Occurring within 2 Hours Post-treatment
Clinical Sign OSPHOS (n=111) Control (n=35)
Uncomfortable, Nervous, Colic, and/or Pawing 9.0% (10) 0% (0)
Lip licking 5.4% (6) 0% (0)
Yawning 4.5% (5) 0% (0)
Head shaking 2.7% (3) 0% (0)
Injection site swelling 1.8% (2) 2.9% (1)
Colic requiring treatment * 0.9% (1) 0% (0)
Hives/Pruritus 0.9% (1) 0% (0)

POST-APPROVAL EXPERIENCE (December 2018): The following adverse events are based on post-approval adverse drug experience reporting. Not all adverse events are reported to FDA/CVM. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data.

The following adverse events are listed in decreasing order of reporting frequency: renal failure, polyuria, polydipsia, abdominal pain, anorexia, lethargy, hypercalcemia, behavioral disorder (e.g.: head shaking, flehmen response, lip licking), discomfort, hyperkalemia, hyperactivity, recumbency, hyperthermia, injection site reactions (pain, edema, inflammation), muscle tremor, urticaria, hyperglycemia, and fracture.

In some cases, death has been reported as an outcome of the adverse events listed above (See PRECAUTIONS).

Contact Information: For a copy of the SDS or to report suspected adverse drug events, contact Dechra at (866) 933-2472. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth.

INFORMATION FOR HORSE OWNERS: Owners should be advised to:

  • NOT administer NSAIDs.
  • Ensure horses have access to adequate water before and after administration of OSPHOS.
  • Observe their horse for at least 2 hours post-treatment for signs of colic, agitation, and/or abnormal behavior.
  • If a horse appears uncomfortable, nervous, or experiences cramping post-treatment, hand walk the horse for 15 minutes. If signs do not resolve contact the veterinarian.
  • Monitor water intake and urine output for 3-5 days post-treatment.
  • Contact their veterinarian if the horse displays abnormal clinical signs such as changes in drinking and urination, appetite, and attitude.

(See PRECAUTIONS and Post-Approval Experience sections.)

CLINICAL PHARMACOLOGY: Clodronate disodium is a non-nitrogen containing bisphosphonate that inhibits bone resorption by binding to calcium phosphate crystals (inhibiting their formation and dissolution), and by exerting direct cellular effects on osteoclasts (inhibiting osteoclast cell function)1. Bound to bone matrix, clodronate disodium enters resorbing osteoclasts, alters their morphology and reduces the number of active osteoclasts, regardless of the cause of osteoclast activity2,3.

In humans, 60 to 80% of clodronate disodium administered intravenously is eliminated unchanged in the urine and 5% in the feces2 ; the remainder of the administered dose is distributed to bone. The bone residence time in horses could not be estimated. However, in numerous studies, the half-life of clodronate disodium in rodent bone (long bones and lumbar vertebrae) has been estimated to be months to years.

After intramuscular injection, clodronate disodium is rapidly absorbed and cleared from the plasma. Within a dosing range of 1.8 to 5.4 mg/kg (n=8 per dose group), the Cmax values increased in proportion to the dose. However, dose related changes were observed after the third administration of a regimen consisting of a single 5.4 mg/kg intramuscular injection administered once every 28 days. In this 3× dose group, a decrease in apparent total systemic clearance (CL/F) was seen (0.08 mL/hr + 0.02; mean + standard deviation), resulting in a greater than proportional increase in systemic drug exposure (AUC, 62.49 hr*mcg/mL ± 18.52) and plasma elimination T ½ (2.89 hours ± 1.33). In comparison, the estimated mean CL/F in horses receiving the 1× (1.8 mg/kg) dose was 0.12 mL/hr + 0.02 (mean + standard deviation) and the corresponding mean pharmacokinetic parameters were 5.36 ± 0.98 mcg/mL (Cmax ), 12.15 ± 1.83 hr*mcg/mL (AUC), 1.65 ± 0.52 hours (T ½) and 20 minutes (Tmax ).

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EFFECTIVENESS: A double masked 3:1 randomized, negative control, multi-site field study evaluated the effectiveness of a single dose of 1.4 mg/kg OSPHOS (maximum dose of 900 mg/horse) for the control of clinical signs associated with navicular syndrome in horses. Enrolled horses had a unilateral or bilateral forelimb lameness of Grade ≥ 2 on the AAEP lameness scale (Grade 0 to 5) and a diagnosis of navicular syndrome based on lameness exam, diagnostic nerve blocks, and radiographic signs indicative of the bony changes associated with navicular syndrome. Horses with radiographic signs indicating concurrent soft tissue injury, osteoarthritis, fractures, or any condition other than the bony changes related to navicular syndrome were not eligible for enrollment. A horse was considered a treatment success if the lameness grade in the primarily affected limb improved by at least 1 AAEP grade and there was no worsening of lameness grade in the other forelimb on Day 56 post-treatment as compared to the pre-treatment assessment. Lameness scores were also recorded on Day 28 and Day 180.

Of the 211 horses screened for enrollment, 146 horses received treatment (111 OSPHOS and 35 saline control). 29% of horses screened for enrollment were not eligible based on radiographic findings. 114 horses (86 OSPHOS, 28 saline control) were included in the statistical analysis. Effectiveness was evaluated on Day 56 post-treatment. On Day 56, 68 of the 86 OSPHOS treated horses and 1 out of 28 saline treated horses were treatment successes. Based on the statistical analysis, the estimated least squares mean success rates are 74.7% and 3.3% for the OSPHOS and saline treated groups, respectively. The difference in success rates is significant at P=0.0028.

Table 2: Day 56 Treatment Success Rate
Study Day OSPHOS Saline P Value *
56 74.7% 3.3% 0.0028

Treatment success based on Day 28 and Day 180 lameness scores was also assessed but not statistically analyzed. At Day 28, 67.4% (60/89) OSPHOS treated horses were considered successes, compared to 20.7% (6/29) in the saline treated group. Day 56 treatment successes were followed to the Day 180 assessment, and Day 56 treatment failures were also considered failures at Day 180. Of the 68 OSPHOS treated horses that were deemed treatment successes on Day 56, 60 were evaluable at Day 180. Of these 60 horses, 51 remained treatment successes at Day 180 based on improvement in lameness grade as compared to Day 0. However, 21 of these 60 evaluable horses demonstrated an increase in lameness grade at Day 180 as compared to their Day 56 evaluation. Including the 18 treatment failures at Day 56, the estimated overall success rate for OSPHOS at Day 180 is 65.4% (51/78).

Table 3: Day 28 and Day 180 Treatment Success Rates
Study Day OSPHOS Saline
28 67.4% (60/89) 20.7% (6/29)
180 65.4% (51/78)* None evaluable

ANIMAL SAFETY: Two studies were conducted to assess the safety of OSPHOS in horses, a six month target animal safety (TAS) study and a two phase study evaluating the safety of concurrent use of the recommended dose of OSPHOS with an NSAID and a single 5× (9 mg/kg) dose of OSPHOS.

Target Animal Safety Study: In the TAS study, OSPHOS was administered to 32 healthy adult horses at 0, 1.8, 3.6 and 5.4 mg/kg (0, 1, 2, and 3× the recommended dose) every 28 days for 6 consecutive months. OSPHOS was administered by intramuscular injection with the total volume divided evenly into at least three separate injection sites with a maximum of 15 mL per injection site.

In the TAS study, the most common post-treatment observations were clinical signs related to abdominal discomfort (colic) and the central nervous system. The incidence of colic was dose related. In the TAS study, colic was observed following 94% (45/48) of 3× treatment administrations, 54% (26/48) of 2× treatment administrations, 4% (2/48) of 1× treatment administrations, and 8% (4/48) of 0× treatment administrations. 80% (36/45) of the 3× horses, 31% (8/26) of 2× horses and none of the 1× (0/2) and 0× (0/4) horses required hand walking to relieve clinical signs associated with colic. In the 3× group, clinical signs of colic often persisted after hand walking and horses were often walked more than once. Colic related clinical signs began shortly after administration (ranging from 1 to 227 minutes post-treatment). No horses in any treatment group received medical treatment and all horses returned to normal within 5.5 hours post-treatment.

In the TAS study, post-treatment clinical signs also included yawning, flehmen, tongue rolling, head shaking and neck writhing. The signs were observed in 50% (4/8) of 0×, 100% (8/8) of 1×, 88% (7/8) of 2×, and 100% (8/8) of 3× horses. All horses returned to normal within 5.5 hours post-treatment.

Table 4: Incidence of Abnormal Clinical Signs in the TAS Study
Number of Observations per Treatment Group
(N=48 treatment administrations per group)
Clinical Sign
Colic * 4 2 26 45
Colic requiring hand walking 0 0 8 36
Yawning 5 17 16 30
Flehmen 0 0 8 2
Tongue rolling 1 10 8 10
Head shaking 1 5 3 7
Neck writhing 0 0 0 6
Pawing 4 4 12 23
Agitation 1 1 7 10
Depression 0 2 5 21
Muscle fasciculations/Trembling 0 0 1 4

Injection site reactions were identified in three 0×, four 1×, two 2×, and one 3× horse. One 1× horse had injection site reactions on two separate treatment days. Injection site reactions in OSPHOS treated horses were characterized by soft or firm swellings, ranged in size from 0.5 cm diameter to 7 × 28 cm, and resolved within 10 days. Clinical pathology evaluations showed a dose related trend for increases in BUN and creatinine post-treatment with the 2× and 3× dose groups having statistically significant elevations as compared to the 0× dose group. Horses in all OSPHOS treated groups had dose dependent elevations in BUN concentrations above the reference range (up to 41 mg/dL; reference range 8-25 mg/dL). Three 3× horses had creatinine concentrations above the reference range (up to 2.5 mg/dL; reference range 0.9-1.9 mg/dL) for up to 12 hours post-treatment. A dose related trend for an increase in potassium was observed for up to 6 hours post-treatment. Individual animal potassium concentrations were within the reference range with the exception of two 3× horses with post-treatment potassium concentrations up to 5.3 mg/dL (reference range 3-5 mg/dL). Decreases in chloride and increases in glucose, creatine kinase, and aspartate aminotransferase were also observed post-treatment. End of study evaluations concluded that bone density (bone mineral concentration) and bone strength (mechanical testing of cortical bone) remained similar between all dose groups.

Two Phase Pilot Study: In Phase I of a two phase pilot study, six horses were administered phenylbutazone orally twice a day at a dose of 4.4 mg/kg on Days 0 to 3, administered OSPHOS at 1.8 mg/kg (1×) by intramuscular injection into 3 sites once on Day 4, and continued on phenylbutazone orally twice a day at a dose of 2.2 mg/kg on Days 4 to 6. In Phase II of the pilot study, after a 15 day washout, the same six horses were administered a single dose of OSPHOS at 9 mg/kg (5×) by intramuscular injection divided evenly into 5 separate injection sites. No NSAIDs were administered in Phase II.

In Phase I, three horses had post-treatment elevations in BUN above the reference range (up to 42 mg/dL; reference range 8-25 mg/dL). BUN concentrations returned to normal prior to Phase II of the study. In Phase II, five out of six horses developed changes in attitude associated with signs of agitation or nervousness including pawing, circling, and tail twitching within 6 minutes of dosing. Four of six horses also developed clinical signs including excessive yawning, flehmen, tongue rolling, head shaking, and head bobbing. All six horses developed mild to moderate muscle fasciculations between 2 and 30 minutes post-treatment. By 30 minutes post-treatment, four out of six horses also developed signs of discomfort and possible abdominal pain including full body stretching, repetitive lying down and rising, and kicking at the abdomen. At approximately one hour post-treatment, one horse exhibited agitation and clinical signs of colic requiring medical therapy. The horse responded to medical therapy and was clinically normal at 7 hours post-treatment. Three out of six horses developed temporary gait abnormalities that included mild to moderate hypermetria, spasticity, or mild ataxia. Four out of six horses developed mildly elevated BUN concentrations by 48 hours post-treatment and one horse had a creatinine concentration slightly above the reference range (2.0 mg/dL; reference range 0.9-1.9 mg/dL) for 12 hours post-treatment.

STORAGE INFORMATION: Store at controlled room temperature 25°C (77°F) with excursions between 15°C-30°C (59°F-86°F) permitted. Single use vial; discard unused portion.

HOW SUPPLIED: OSPHOS is supplied in cartons with each carton containing one clear glass 20 mL vial with 15 mL (900 mg) clodronate disodium (60 mg/mL) per vial.

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NDC 17033-460-15

MANUFACTURED FOR:
Dechra Veterinary Products
7015 College Boulevard, Suite 525
Overland Park, KS 66211 USA

For a copy of the Safety Data Sheet (SDS) or to report adverse reactions call Dechra Veterinary Products at (866) 933-2472.

Manufactured in Canada.

Approved by FDA under NADA # 141-427

OSPHOS - Dechra Veterinary Products: Veterinary Package Insert (2)

US Patent 7,781,420

OSPHOS is a registered trademark of Dechra Ltd. All rights reserved.

© 2018 Dechra Ltd.

1
Fleisch H. 1987. Bisphosphonates-history and experimental basis. Bone 8: S23-28.
2
Plosker GL, Goa KL. 1994. Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Drugs 47: 945-982.
3
Flanagan AM, Chambers TJ. 1989. Dichloromethylene bisphosphonate (Cl2MBP) inhibits bone resorption through injury to osteoclasts that resorb Cl2MBP-coated bone. Bone Miner: 6:33-43.

Rev. December 2018

Dechra

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https://vetlabel.com/lib/vet/meds/osphos-1/

FAQs

How much does Osphos horse cost? ›

A dose of Osphos costs between $300 and $500. When vets had to import Tildren from France, it cost $1,000 per dose, but the price should drop now that Tildren is also approved for sale in the U.S.

How long does it take Osphos to work? ›

It may take two months to see the maximum effect. You administer OSPHOS by intramuscular injection. The total volume should be divided equally into three injection sites. Similar to TILDREN, it may take two months to see the most clinical improvement.

How often can you give Osphos? ›

OSPHOS may be re-administered at 3- to 6-month intervals based on FDA approval safety studies. The exact timing of the re-dosing is variable based upon each case. Dechra recommends re-dosing be determined by an attending veterinarian who can evaluate recurrence of clinical signs.

What does Osphos treat in horses? ›

OSPHOS is a newer drug to help reduce lameness associated with Navicular Syndrome. We have seen promising results in horses battling this debilitating disease.

Can you ride a horse after an Osphos injection? ›

Horses should be monitored for at least 2 hours following administration of OSPHOS. Bisphosphonates affect plasma concentrations of some minerals and electrolytes such as calcium, magnesium and potassium, immediately post-treatment, with effects lasting up to several hours.

Does Osphos help with arthritis? ›

OsPhos is an injectable product that first came out in Europe to treat navicular disease. We are now using it to treat not only navicular disease, but also many forms of arthritis. It can be particularly effective on hock and coffin joint arthritis.

What is the difference between Osphos and Tildren? ›

Even though they are in the same drug class, Osphos and Tildren have different methods of administration. Tildren is administered intravenously via a catheter, over the course of 90 minutes. Osphos is administered via an intramuscular injection, with the dose being split over three different sites.

How do I give my horse Osphos? ›

Osphos is administered via intramuscular injection and should be evenly spread over three injection sites. Osphos is a solution for injection. It comes packaged as a 15 ml vial and one vial is sufficient to treat one horse. The recommended dosage is 1.8 mg of Clodronate Disodium per kg of bodyweight.

How much do navicular injections cost? ›

Approximate cost: Typically between $150 and $400, depending on the clinician and equipment used. Now what? If a specific soft-tissue injury is identified, it could be possible to treat the area with injections such as platelet-rich plasma or stem cells.

Can a horse recover from navicular? ›

Navicular disease can be treated but rarely cured. Corrective trimming and shoeing is important to ensure level foot fall and foot balance. Often a rolled toe egg bar shoe is used to encourage early break over at the toe and good heel support.

Can a horse with navicular go barefoot? ›

Ideally, horses with navicular disease should never go barefoot. Shoes are not only helpful in addressing abnormalities and imbalances, they also provide protection for your horse's sensitive feet.

Can a horse with navicular be ridden? ›

Can a horse with navicular be ridden? Depending on the severity of the disease, it is possible to ride a horse with navicular, as long as your vet okays it. Pharmaceutical agents which can help alleviate pain and control inflammation such as Previcox and Tildren can be administered.

What is Osphos injection? ›

OSPHOS is an injectable bisphosphonate solution for the control of clinical signs associated with navicular syndrome in horses four years and older.

What can be done for navicular? ›

Nonsurgical treatment of navicular syndrome consists of rest, hoof balance and corrective trimming/shoeing, and medical therapy, including administration of systemic antiinflammatories, hemorheologic medications, and intraarticular medications.

What is the difference between legend and adequan? ›

Adequan is incorporated directly into the cartilage where it helps with the compression capabilities of the joint. It has been shown to help heal and aid in the long term health of articular cartilage. Legend is pure Hyaluronic Acid that is utilized by the synovial cells that line the joint capsule.

What is horse pentosan? ›

Pentosan polysulfate sodium 250 mg/mL . An aid in the treatment of non-infectious, inflammatory joint disease in horses. This item requires a prescription from your local veterinarian.

What does it mean when a horse's hocks are fusing? ›

Fusing begins when the protective cartilage in the joint wears away and synovial fluid production decreases. Bones begin rubbing against each other irritating the bone, promoting bony growth resulting in degenerative joint disease (DJD), or osteoarthritis. Eventually, the bony growth will fuse the bones together.

What is Tildren for horses? ›

Tildren® (tiludronate) has been used for a number of years by veterinarians in Europe to treat joint conditions such as navicular disease and bone spavin. It works by regulating bone remodelling in cases where there is too much bone resorption and now has a licence for use in the UK.

How long does Tildren take to work? ›

As a rule, people won't see immediate effects from Tildren. It takes time to work, and the maximum benefit will be seen in about two months.

Does adequan help navicular? ›

Many horses with Navicular Syndrome require intra-articular (injected into the joint space) steroids and hyaluronic acid (HA). These joint injections are done to slow down the arthritic change associated with Navicular. Many horses are also treated with Adequan or Legend to promote joint health.

What is Osfos? ›

Drug Therapy (Tildren, Osfos)

Tildren and Osphos, commonly known bisphosphonates, are the only drugs available to treat bone pain associated with these diseases. Previously, these drugs were only available in Europe, and only since 2014 have they been approved for use in the US.

Can a horse with navicular still be ridden? ›

Can a horse with navicular be ridden? Depending on the severity of the disease, it is possible to ride a horse with navicular, as long as your vet okays it. Pharmaceutical agents which can help alleviate pain and control inflammation such as Previcox and Tildren can be administered.

What is Osphos? ›

OSPHOS is an injectable bisphosphonate solution for the control of clinical signs associated with navicular syndrome in horses four years and older.

Can navicular in horses be cured? ›

Navicular disease can be treated but rarely cured. Corrective trimming and shoeing is important to ensure level foot fall and foot balance. Often a rolled toe egg bar shoe is used to encourage early break over at the toe and good heel support.

Is navicular in horses genetic? ›

This disease is believed to be genetic but can occur due to the conformation of the distal limbs. Structure associated with Navicular syndrome includes excessively long toes, under-run heels, and a “broken back” hoof-pastern axis.

Videos

1. How to Prepare a Subcutaneous (SQ) Fluids Bag for your Pet
(VetVid)
2. Ask the Vet - Dealing with Navicular issues in horses
(SmartPak)
3. [Webinar] Various Strategies for Managing Navicular Syndrome
(AFJTV)
4. Ask the Vet - Long-term use of Equioxx in horses
(SmartPak)
5. Grayson Vet Chats with Dr. Ben Sykes, Associate Prof. Equine Internal Medicine – Massey University
(Grayson JockeyClub)
6. Grayson Vet Chat with University of California Davis Dr. Heather Knych.
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