Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis (2022)

Background: Patients with rheumatoid arthritis (RA) may have more prevalent and severe periodontitis than healthy controls. Periodontitis may increase the systemic inflammation in RA. The aim of this study is to assess periodontitis prevalence and severity and its potential association with systemic inflammation in Indonesian patients with RA.

Methods: A full-mouth periodontal examination including probing depth, gingival recession, plaque index, and bleeding on probing was performed in 75 Indonesians with RA and 75 age-, sex-, and smoking-matched Indonesian controls. A validated questionnaire was used to assess smoking, body mass index, education, and medical conditions. In addition, in all participants, the use of drugs was noted, and erythrocyte sedimentation rates and serum levels of high-sensitivity C-reactive protein (hsCRP), rheumatoid factor, and anti-citrullinated protein antibodies were measured. Differences in periodontitis prevalence and 12 measures of periodontitis severity between patients with RA and controls were analyzed using univariate analyses.

Results: No significant differences in periodontitis prevalence and 11 measures of periodontitis severity between patients with RA and controls were observed. Conversely, patients with RA had a significantly lower surface area of healthy pocket epithelium versus controls (P = 0.008), and a tendency toward higher hsCRP levels was observed in patients with RA with severe periodontitis compared with patients with RA with no mild or moderate periodontitis (P = 0.063). It has to be noted that all patients with RA were on anti-inflammatory drugs, whereas none of the controls used such drugs.

Conclusion: Prevalence and severity of periodontitis in Indonesian patients with RA is comparable to controls but with less healthy pocket epithelium than in controls and a tendency toward a higher inflammatory state in patients with RA and severe periodontitis.

Original languageEnglish
Pages (from-to)1067-1074
Number of pages8
JournalJournal of Periodontology
Volume84
Issue number8
DOIs
Publication statusPublished - Aug-2013
  • Arthritis
  • rheumatoid
  • C-reactive protein
  • inflammation
  • periodontal pocket
  • periodontitis
  • prevalence
  • C-REACTIVE PROTEIN
  • GINGIVAL CREVICULAR FLUID
  • INFLAMED SURFACE-AREA
  • AGGRESSIVE PERIODONTITIS
  • DISEASE
  • ASSOCIATION
  • POPULATION
  • CYTOKINE
  • ADULTS
  • SERUM
  • APA
  • Author
  • BIBTEX
  • Harvard
  • Standard
  • RIS
  • Vancouver

Susanto, H., Nesse, W., Kertia, N., Soeroso, J., van Reenen, Y. H., Hoedemaker, E., Agustina, D., Vissink, A., Abbas, F., Dijkstra, P. U., & Soeroso§, J. (2013). Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis. Journal of Periodontology, 84(8), 1067-1074. https://doi.org/10.1902/jop.2012.110321

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Susanto, Hendri ; Nesse, Willem ; Kertia, Nyoman ; Soeroso, Juwono ; van Reenen, Yvonne Huijser ; Hoedemaker, Eveliene ; Agustina, Dewi ; Vissink, Arjan ; Abbas, Frank ; Dijkstra, Pieter U. ; Soeroso§, Juwono. / Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis. In: Journal of Periodontology. 2013 ; Vol. 84, No. 8. pp. 1067-1074.

@article{ea67b12f04544f4a82dfc5ff5acbfe1d,

title = "Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis",

abstract = "Background: Patients with rheumatoid arthritis (RA) may have more prevalent and severe periodontitis than healthy controls. Periodontitis may increase the systemic inflammation in RA. The aim of this study is to assess periodontitis prevalence and severity and its potential association with systemic inflammation in Indonesian patients with RA.Methods: A full-mouth periodontal examination including probing depth, gingival recession, plaque index, and bleeding on probing was performed in 75 Indonesians with RA and 75 age-, sex-, and smoking-matched Indonesian controls. A validated questionnaire was used to assess smoking, body mass index, education, and medical conditions. In addition, in all participants, the use of drugs was noted, and erythrocyte sedimentation rates and serum levels of high-sensitivity C-reactive protein (hsCRP), rheumatoid factor, and anti-citrullinated protein antibodies were measured. Differences in periodontitis prevalence and 12 measures of periodontitis severity between patients with RA and controls were analyzed using univariate analyses.Results: No significant differences in periodontitis prevalence and 11 measures of periodontitis severity between patients with RA and controls were observed. Conversely, patients with RA had a significantly lower surface area of healthy pocket epithelium versus controls (P = 0.008), and a tendency toward higher hsCRP levels was observed in patients with RA with severe periodontitis compared with patients with RA with no mild or moderate periodontitis (P = 0.063). It has to be noted that all patients with RA were on anti-inflammatory drugs, whereas none of the controls used such drugs.Conclusion: Prevalence and severity of periodontitis in Indonesian patients with RA is comparable to controls but with less healthy pocket epithelium than in controls and a tendency toward a higher inflammatory state in patients with RA and severe periodontitis.",

keywords = "Arthritis, rheumatoid, C-reactive protein, inflammation, periodontal pocket, periodontitis, prevalence, C-REACTIVE PROTEIN, GINGIVAL CREVICULAR FLUID, INFLAMED SURFACE-AREA, AGGRESSIVE PERIODONTITIS, DISEASE, ASSOCIATION, POPULATION, CYTOKINE, ADULTS, SERUM",

author = "Hendri Susanto and Willem Nesse and Nyoman Kertia and Juwono Soeroso and {van Reenen}, {Yvonne Huijser} and Eveliene Hoedemaker and Dewi Agustina and Arjan Vissink and Frank Abbas and Dijkstra, {Pieter U.} and Juwono Soeroso{\^A}§",

year = "2013",

month = aug,

doi = "10.1902/jop.2012.110321",

language = "English",

volume = "84",

pages = "1067--1074",

journal = "Journal of Periodontology",

issn = "0022-3492",

publisher = "Wiley",

number = "8",

(Video) Dental Health and Rheumatoid Arthritis

}

Susanto, H, Nesse, W, Kertia, N, Soeroso, J, van Reenen, YH, Hoedemaker, E, Agustina, D, Vissink, A, Abbas, F, Dijkstra, PU & Soeroso§, J 2013, 'Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis', Journal of Periodontology, vol. 84, no. 8, pp. 1067-1074. https://doi.org/10.1902/jop.2012.110321

Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis. / Susanto, Hendri; Nesse, Willem; Kertia, Nyoman; Soeroso, Juwono; van Reenen, Yvonne Huijser; Hoedemaker, Eveliene; Agustina, Dewi; Vissink, Arjan; Abbas, Frank; Dijkstra, Pieter U.; Soeroso§, Juwono.

In: Journal of Periodontology, Vol. 84, No. 8, 08.2013, p. 1067-1074.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis

AU - Susanto, Hendri

AU - Nesse, Willem

AU - Kertia, Nyoman

AU - Soeroso, Juwono

AU - van Reenen, Yvonne Huijser

AU - Hoedemaker, Eveliene

AU - Agustina, Dewi

(Video) 3/12/2021: How Not to Get Rheumatoid Arthritis

AU - Vissink, Arjan

AU - Abbas, Frank

AU - Dijkstra, Pieter U.

AU - Soeroso§, Juwono

PY - 2013/8

Y1 - 2013/8

N2 - Background: Patients with rheumatoid arthritis (RA) may have more prevalent and severe periodontitis than healthy controls. Periodontitis may increase the systemic inflammation in RA. The aim of this study is to assess periodontitis prevalence and severity and its potential association with systemic inflammation in Indonesian patients with RA.Methods: A full-mouth periodontal examination including probing depth, gingival recession, plaque index, and bleeding on probing was performed in 75 Indonesians with RA and 75 age-, sex-, and smoking-matched Indonesian controls. A validated questionnaire was used to assess smoking, body mass index, education, and medical conditions. In addition, in all participants, the use of drugs was noted, and erythrocyte sedimentation rates and serum levels of high-sensitivity C-reactive protein (hsCRP), rheumatoid factor, and anti-citrullinated protein antibodies were measured. Differences in periodontitis prevalence and 12 measures of periodontitis severity between patients with RA and controls were analyzed using univariate analyses.Results: No significant differences in periodontitis prevalence and 11 measures of periodontitis severity between patients with RA and controls were observed. Conversely, patients with RA had a significantly lower surface area of healthy pocket epithelium versus controls (P = 0.008), and a tendency toward higher hsCRP levels was observed in patients with RA with severe periodontitis compared with patients with RA with no mild or moderate periodontitis (P = 0.063). It has to be noted that all patients with RA were on anti-inflammatory drugs, whereas none of the controls used such drugs.Conclusion: Prevalence and severity of periodontitis in Indonesian patients with RA is comparable to controls but with less healthy pocket epithelium than in controls and a tendency toward a higher inflammatory state in patients with RA and severe periodontitis.

AB - Background: Patients with rheumatoid arthritis (RA) may have more prevalent and severe periodontitis than healthy controls. Periodontitis may increase the systemic inflammation in RA. The aim of this study is to assess periodontitis prevalence and severity and its potential association with systemic inflammation in Indonesian patients with RA.Methods: A full-mouth periodontal examination including probing depth, gingival recession, plaque index, and bleeding on probing was performed in 75 Indonesians with RA and 75 age-, sex-, and smoking-matched Indonesian controls. A validated questionnaire was used to assess smoking, body mass index, education, and medical conditions. In addition, in all participants, the use of drugs was noted, and erythrocyte sedimentation rates and serum levels of high-sensitivity C-reactive protein (hsCRP), rheumatoid factor, and anti-citrullinated protein antibodies were measured. Differences in periodontitis prevalence and 12 measures of periodontitis severity between patients with RA and controls were analyzed using univariate analyses.Results: No significant differences in periodontitis prevalence and 11 measures of periodontitis severity between patients with RA and controls were observed. Conversely, patients with RA had a significantly lower surface area of healthy pocket epithelium versus controls (P = 0.008), and a tendency toward higher hsCRP levels was observed in patients with RA with severe periodontitis compared with patients with RA with no mild or moderate periodontitis (P = 0.063). It has to be noted that all patients with RA were on anti-inflammatory drugs, whereas none of the controls used such drugs.Conclusion: Prevalence and severity of periodontitis in Indonesian patients with RA is comparable to controls but with less healthy pocket epithelium than in controls and a tendency toward a higher inflammatory state in patients with RA and severe periodontitis.

KW - Arthritis

KW - rheumatoid

KW - C-reactive protein

KW - inflammation

KW - periodontal pocket

KW - periodontitis

KW - prevalence

KW - C-REACTIVE PROTEIN

KW - GINGIVAL CREVICULAR FLUID

KW - INFLAMED SURFACE-AREA

KW - AGGRESSIVE PERIODONTITIS

KW - DISEASE

(Video) The RA and Oral Health Connection

KW - ASSOCIATION

KW - POPULATION

KW - CYTOKINE

KW - ADULTS

KW - SERUM

U2 - 10.1902/jop.2012.110321

DO - 10.1902/jop.2012.110321

M3 - Article

VL - 84

SP - 1067

EP - 1074

JO - Journal of Periodontology

JF - Journal of Periodontology

SN - 0022-3492

IS - 8

ER -

Susanto H, Nesse W, Kertia N, Soeroso J, van Reenen YH, Hoedemaker E et al. Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis. Journal of Periodontology. 2013 Aug;84(8):1067-1074. https://doi.org/10.1902/jop.2012.110321

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