Rheumatoid Arthritis - Arthritis Rheumatism (2023)

ICD-9 Code: RA, 714.0; Felty syndrome, 714.1; rheumatoid vasculitis, 447.6;rheumatoid nodules, 729.89.

(Video) What is Rheumatoid Arthritis? | Johns Hopkins Rheumatology

ICD-10 Code:M05 – M06

What is it?

RA is a chronic, progressive, systemic inflammatory disorder in which the joints are the primary target. The classic presentation of RA is a symmetric polyarthritis, particularly of the small joints of the hands and feet. Early arthritis is often accompanied by constitutional symptoms such as fatigue.

What causes it?

The etiology of RA is unknown. The pathophysiology of RA is presumed to relate to a persistent immunologic response of a genetically susceptible host to some unknown antigen, possibly an infectious agent. Many infections have been suggested as the cause of RA (including mycobacteria, streptococci, Mycoplasma, Yersinia, rubella, Epstein-Barr virus). Despite the resemblance of RA to known infectious arthritides (e.g., Lyme disease) and extensive investigations, no single agent has ever been conclusively implicated. Recently, environmental factors have been implicated in the pathogenesis of RA – with the risk and severity decreasing with alchohol use or, increasing with obesity, periodontal disease, and smoking.

Genetics: Family studies demonstrate some genetic predisposition to the development of RA. However, the concordance rate for monozygotic twins is only approximately15% (i.e., if one twin has RA, there is a 15% chance that the other will develop RA). First-degree relatives of patients with RA develop RA at a rate approximately four times that of the general population. The most clearly defined genetic association with RA is with particular alleles of the class II major histocompatibility complex genes. Some HLA-DR molecules (e.g., HLA-DR4, HLA-DR1,currently designated HLA-DRB1*0401, 0101, 0404, etc.) are associated with the development and severity of RA.

Pathology: The most characteristic pathologic changes in RA occur in the joints. RA can affect any diarthrodial joint (i.e., joints witha layer of cartilage overlying bone, and a joint cavity that is lined by a synovial membrane and that contains synovial fluid). With the onset of arthritis, the normally thin synovial lining layer hypertrophies and becomes edematous and infiltrated with mononuclear cells. Below the synovial layer are organized accumulations of predominantly CD4+ helper T cells and antigen-presenting cells (dendritic cells and macrophages). Lymphoid follicles and germinal centers, more characteristic of primary lymphoid organs such as lymph nodes, canalso seen in the rheumatoid synovium. In these areas, large amounts of immunoglobulin, including RF, are produced. Substantial vascular changes (e.g., angiogenesis) reflect activation of the endothelium of the synovial blood vessels. Fibroblast activity is reflected by increased synthesis of extracellular matrix components. This inflamed synovium distends the joint space, erodes into subchondral bone, and destroys cartilage. Such alterations are not pathognomonic of RA and may be seen in the other inflammatory arthritides. However, the intensity of such changes is characteristic of RA. The synovial fluid in RA is inflammatory in nature and contains large numbers of neutrophils. Rheumatoid nodules show palisading histiocytes arrayed about an area of central necrosis. Although uncommon, vasculitis of small- or medium-sized vessels has been reported.

(Video) Rheumatoid Arthritis Update: 2020

Immunologically, several components of the immune system contribute to the pathogenesis of RA. Several lines of evidence indicate that activated CD4+ helper T cells orchestrate the immune response in RA. In addition to T cells, cells of the monocyte/macrophage lineage play an important role, both by interacting with T cells and by secretingvarious cytokines, chemokines, and other inflammatory mediators. Many manifestations of RA derive from the effects of proinflammatory cytokines, particularly IL-1, TNF-a, and IL-6. B cells play a role in RA,and can function asantigen-presenting cells, secreting cytokines and other mediators,and by secreting RF (usually IgM-RF, which binds to the Fc portion of IgG) that contributes to RA damage by forming immune complexes.Impairedapoptosis within the rheumatoid synovium may help sustain the ongoing immune and inflammatory activity.

Who gets it?

The prevalence of RA is remarkably consistent; throughout the world, it affects approximately 0.8% of the population. Exceptions include the scarcity of RA in rural sub-Saharan Africa and a higher prevalence of RA (>5%) among somenative North American populations. In all populations, women are affected approximately three times as often as men. The prevalence of RA increases with age, and sex differences diminish among older patients. RA develops most commonly during the fourth and fifth decades of life. Peak onset age (80% of cases) is between 35 and 50 years. There is some evidence that the prevalence of RA has decreased in the last few decades such that ther are now 1.3 million Americans with RA.

Risk Factors: The greater prevalence of RA among women argues for some effect of sex hormones on the disease. This is supported by the tendency of RA to improve during pregnancy and with oral contraceptive use. Smoking may contribute to disease risk and risk of extraarticular manifestations, particularly among patients with antibodies to citrullinated proteins (ACPA). Historical evidence supportsenvironmental exposures as potentialrisk factor for RA. Thus, unlike other types of arthritis such as OA and gout, it does not appear that RA existed to any great extentbefore the industrial age.

What are the symptoms?

RA is a clinical diagnosis, easily made by detailed history and thorough musculoskeletal examination.
—Onset: For approximately two-thirds of patients, the onset of RA is insidious; symmetric arthritis develops over the course of weeks to months. Approximately 10% to 15% of patients have a fulminant onset of polyarticular arthritis, and the diagnosis of RA is established more easily. Arthritis is often accompanied by prolonged morning stiffness affecting the joints that typically lasts an hour or more. Many patients also have constitutional symptoms such as fatigue, anorexia, and low-grade fever.
—Joints: Although the cardinal signs of inflammation (pain, swelling, erythema, warmth) may be seen early in the disease course or during flares, erythema and warmth may be absent in chronic RA. Warmth is often a subtle finding and erythema may be short-lived. Pain referred to the joint originates predominantly from the joint capsule, which is abundantly supplied with pain fibers and is exquisitely sensitive to distention. Factors that contribute to swelling of the joint include accumulation of synovial fluid and hypertrophy of the synovium. Initially, the patient may voluntarily restrict motion in response to pain. With progression of disease, tendon shortening and destruction of periarticular supporting structures may cause irreversible joint deformities (e.g., swan-neck deformity). Bony ankylosis (destruction of joints with collapse and bony overgrowth) tends to occur in some joints, particularly the wrist and ankle. Loss of function is critical to the patient because it is associated with interference with the ability to perform activities of daily living and substantial morbidity.

Table.Joint Involvement in Rheumatoid Arthritis
Involved JointFrequency (%)
Proximal interphalangeal
Ankle (tibiotalar + subtalar)
Midfoot (tarsus)
Cervical spine

—Deformities: Damage to articular and periarticular (i.e., tendons, ligaments) structures may result in deformities (Figure), including swan-neck deformity (manifest as hyperextension at the proximal interphalangeal joints and flexion at the distal interphalangeal joints of the fingers); boutonnière deformity (flexion at the proximal interphalangeal joint and hyperextension at the distal interphalangeal joint), ulnar drift (deviation of the metacarpophalangealjoint and fingers ulnarly), piano-key deformity (with manual compression, prominent up and down movement of the ulnar styloid, caused by damage at the radioulnar joint), bent-fork deformity of the wrist (owing to collapse of the carpal bones with subluxation at the carpometacarpal joints, which re- sults in a step-down appearance over the dorsum of the wrist), and hallux valgus (valgus deformity affecting the first metatarsophalangeal joints, with medial displacement at the metatarsophalangeal joint and outward deviation of the first toe bilaterally).Although RA can affect any diarthrodial joint, there is a distinctive additive and symmetric pattern of involvement, with a predilection for the small joints of the hands and feet and certain large joints (see Table). Some joints yieldparticular concern to patients; for example, arthritis of the hands and wrists interferes substantially with daily life and activities of self-care, while large joints (e.g., knees or hips) hamper mobility and often prompts patients to seek medical advice.

(Video) Rheumatoid Arthritis - Signs & Symptoms | Johns Hopkins Medicine

Rheumatoid Arthritis - Arthritis Rheumatism (1)

Figure. Rheumatoid arthritis hand deformities (Clockwise from top-left: Swan neck deformity, boutinierre deformity, hallux valgus, and ulnar drift)

—Extraarticular manifestations: Although arthritis may be its most prominent clinical feature, RA is indeed a systemic disease. Many patients have a variety of extraarticular manifestations. Extraarticular manifestations tend to occur in patients with high titers of RF in the serum. Some manifestations, for example, Sjogrens syndrome and subcutaneous rheumatoid nodules, are common (>30% of patients with RA) but usually does not require specific intervention nor will they be controlled by antirheumatic drugs proven to benefit the joints. Rheumatoid nodules are commonly seen over the ulna, olecranon, fingers, and Achilles tendon or in the olecranon bursa. Rheumatoid nodules are only seen in patients with RF (often in high titers) and may be confused with gouty tophi, ganglion cysts, tendon xanthomas, or nodules associated with rheumatic fever, leprosy, MCTD, or multicentric reticulohistiocytosis. Pulmonary manifestations of RA are also common (some pathologic changes may be seen almost universally at autopsy) but infrequently become clinically apparent. This may include interstitial lung disease (“rheumatoid lung”), chronic pleural effusions, and rheumatoid nodules in the lungs. Some extraarticular manifestations (e.g., vasculitis, Felty syndrome) are rare but often require specific therapy (see Rheumatoid Vasculitis and Felty’s syndrome).

Extraarticular Manifestations of Rheumatoid Arthritis
RenalAmyloidosis, renal tubular acidosis, interstitial nephritis
Metabolic Osteoporosis
ConstitutionalFever, anorexia, fatigue, weakness, lymphadenopathy
CutaneousRheumatoid nodules, vasculitis
OcularSjögren syndrome (keratoconjunctivitis sicca), scleritis, episcleritis
CardiovascularPericarditis, pericardial effusion
PulmonaryPleuritis, pleural effusion, interstitial fibrosis, rheumatoid nodules in the lung, Caplan syndrome (nodular pulmonary infiltrates in patients with RA with pneumoconiosis)
HematologicAnemia of chronic disease, thrombocytosis, eosinophilia, Felty syndrome (RA associated with neutropenia and splenomegaly)
GastrointestinalSjögren syndrome (xerostomia), amyloidosis, rheumatoid vasculitis
NeurologicMononeuritis multiplex, Entrapment neuropathy (amyloid or inflammation), myelopathy/myositis

Complications: Joint destruction and deformities are the most common complications of RA. These changes can substantially impair the patient’s mobility as well as the ability to perform activities of daily living (e.g., preparing food, bathing, dressing). Extraarticular manifestations of RA may also cause complications (e.g., symptomatic pleural or pericardial effusion, vasculitic damage). Subluxation of upper cervical vertebrae is commonly seen on radiographs but is usually asymptomatic. Rarely, C1-2 subluxation results in spinal cord compression with permanent neurologic deficit. Rarely will pulmonary rheumatoid nodules erode into bronchi and cause recurrent or isolated pneumothorax.

(Video) Rheumatoid Arthritis - Treatment | Johns Hopkins

Death: Patients with RA have an increased mortality rate and reduced survival by 10 to 18 years. The leading cause of death in RA is cardiovascular events (especially in women), chronic lung disease, serious infection and neoplasia. These comorbid conditions are directly or indirectly the result of chronic uncontrolled systemic inflammation. As such RA patients have higher rates ofcardiovascular disease, infection, renal disease, neoplasia, and other comorbidities. Patients with RA have a nearly twofold increased rate of myocardial infarction, heart failure, and cardiovascular accidents. Interestingly, inflammation controlled by successfully treatment with MTX or TNF inhibitors results inbetter survival and a lower rate of CV deaths. Although the overall cancer risk in RA is not increased and the standardize incidence rate (SIR) or relative risk approximates 1. However, this is misleading as patients with RA have a lower rate of colon and breast cancer (owing to NSAID use) but are at increased risk of lymphoma (primarily non-Hodgkins lymphoma, lung cancer, non-melanomatous skin cancer and possibly a higher risk of melanoma or leukemia. Lastly, patients with RA are at risk of serious infections. Pneumonia is the leading cause of death due to infection. Risk for serious, often hospitalized, infections is primarily related to: 1) RA severity, inflammation and debility, 2) comorbidities (especially diabetes and chronic lung disease), 3) corticosteroid use, 4) skin breakdown and surgery. With each morbid/mortal risk, RA severity appears to contribute to this risk more so than the DMARD or immunosuppressive therapies employed.

How is it diagnosed?

No laboratory test is diagnostic for RA; rather, the presence of various laboratory findings provide support for a clinically suspected diagnosis. Rheumatoid factor (RF) is the laboratory test most closely associated with RA. RF is an autoantibody (usually IgM) that binds to the Fc portion of IgG and is present in 75% to 85% of patients with RA. Thus, nearly 20% of patients with RA are seronegative for RF. Moreover, cut-offs for a normal and abnormal RF lever are defined such that 4-5% of the general population test positive for RF. Using these same “normal range” values, up to 15% of healthy elderly persons may be RF positive. In addition, an abnormal RF titer is seen in a number of conditions other than RA, including Sjögren syndrome, cryoglobulinemia, SLE, bacterial endocarditis, mycobacterial disease, hepatitis, and lymphoproliferative malignancies. Because RA is present in approximately 0.8% of the population, random screening using RF would be expected to generate a large number of false-positive results. In patients with RA, high-titer RF is associated with aggressive disease, as indicated by higher risks of developing bony erosions, extraarticular involvement, and functional disability. The expanded use of ELISA assays for anti-cyclic citrullinated peptide (CCP) antibodies (anti-CCP or ACPA)and 14-3-3η complement the profile provided by RF. Although anti-CCP antibodies appear to have nearly the same sensitivity (60%–70%) as RF, they appear to be more specific for RA (~95%) and are found earlier in the disease course and among those at risk of more severe outcomes. Newer assays for anti-carbamylated antibodies show an association with RA and risk of radiographic damage, however their added benefit and commercially available is currently lacking.

Other laboratory tests that can be useful in supporting the diagnosis of RA include synovial fluid analysis, measurement of acute-phase reactants (ESR and CRP), and the CBC. In RA, synovial fluid is expected to be inflammatory (2000-60,000 cells/mm3) with a neutrophilic predominance (70-85% PMNs) and negative results on microbiologic culture and crystal analysis. Elevation in the ESR or CRP level provides a surrogate measure of active inflammation and may be useful in establishing a diagnosis, estimating the prognosis, and gauging the response to therapy. The most common abnormality in the CBC in patients with RA is a normochromic, normocytic anemia (anemia of chronic disease). Thrombocytosis may also be seen with uncontrolled inflammation. Although, nonspecific mild (two-fold) elevation of alkaline phosphatase is seen sporadically, other hepatocellular enzymes are normal in RA.

Imaging: Several imaging studies are used in assessing patients with RA. Early in the disease course, plain radiographs may show only soft tissue swelling or joint effusion. As the disease progresses, more abnormalities develop.

Adapted from: RheumaKnowledgy

(Video) Treatment Options for Rheumatoid Arthritis | Johns Hopkins Rheumatology


Rheumatoid Arthritis - Arthritis Rheumatism? ›

Rheumatoid arthritis is an autoimmune disease. This means your immune system (which usually fights infection) attacks the cells that line your joints by mistake, making the joints swollen, stiff and painful. Over time, this can damage the joints, cartilage and nearby bone.

Is rheumatoid arthritis the same as rheumatism? ›

Rheumatoid arthritis is an inflammatory autoimmune condition that leads to swelling in the joints. It may also cause a fever and other symptoms. When people use the word “rheumatism,” they often mean rheumatoid arthritis. When people use the word “arthritis,” they are sometimes referring to osteoarthritis.

What is the difference between arthritis & rheumatism? ›

Osteoarthritis, the most common form of arthritis, involves the wearing away of the cartilage that caps the bones in your joints. Rheumatoid arthritis is a disease in which the immune system attacks the joints, beginning with the lining of joints.

What is the main cause of rheumatoid arthritis? ›

Rheumatoid arthritis is an autoimmune condition, which means it's caused by the immune system attacking healthy body tissue. However, it's not yet known what triggers this. Your immune system normally makes antibodies that attack bacteria and viruses, helping to fight infection.

Is there a cure for rheumatism? ›

There is no cure for rheumatoid arthritis. But clinical studies indicate that remission of symptoms is more likely when treatment begins early with medications known as disease-modifying antirheumatic drugs (DMARDs).

What is rheumatism called today? ›

The term rheumatism is a loosely used layperson term to describe rheumatoid arthritis. The rheumatoid disorders include those affecting muscles, joints and bones. They are common and have a huge impact on the health of a vast population worldwide.

What is the most painful type of arthritis? ›

Rheumatoid arthritis can be one of the most painful types of arthritis; it affects joints as well as other surrounding tissues, including organs. This inflammatory, autoimmune disease attacks healthy cells by mistake, causing painful swelling in the joints, like hands, wrists and knees.

What is rheumatism pain like? ›

The quality of rheumatic pain is typically a deep aching sensation, but the word "soreness" is also used, perhaps to emphasize the pain on motion and tenderness to touch.

What are the 3 types of arthritis? ›

The Three Most Common Types of Arthritis
  • Osteoarthritis. Osteoarthritis the most common form of arthritis. ...
  • Rheumatoid Arthritis. Rheumatoid arthritis is an autoimmune disease, which means that the immune system attacks parts of the body—especially the joints. ...
  • Psoriatic Arthritis.
Jun 28, 2017

Is rheumatoid arthritis serious? ›

RA is a very serious autoimmune disease, in which your immune system mistakenly attacks your own body's tissues and causes severe joint pain, stiffness, severe fatigue, and sometimes deformity, usually in the hands, shoulders, knees, and/or feet.

What age does RA usually start? ›

You can get rheumatoid arthritis (RA) at any age, but it's most likely to show up between ages 30 and 50. When it starts between ages 60 and 65, it's called elderly-onset RA or late-onset RA. Elderly-onset RA is different from RA that starts in earlier years.

What blood test shows rheumatoid arthritis? ›

An anti-CCP antibody test — also called an ACCP test or CCP-test — looks for the presence of these antibodies to help confirm rheumatoid arthritis. An anti-CCP test can also help doctors determine the severity of a rheumatoid arthritis case.

What is the best treatment for rheumatoid arthritis? ›

Methotrexate is usually the first medicine given for rheumatoid arthritis, often with another DMARD and a short course of steroids (corticosteroids) to relieve any pain. These may be combined with biological treatments.
The DMARDs that may be used include:
  • methotrexate.
  • leflunomide.
  • hydroxychloroquine.
  • sulfasalazine.

What is the latest treatment for rheumatoid arthritis? ›

Official answer. The newest drugs for the treatment of rheumatoid arthritis are the Janus kinase (JAK) inhibitors, which are FDA approved under the brand names Rinvoq, Olumiant, and Xeljanz.

How painful is rheumatoid arthritis? ›

If you have RA, joint pain can range from mild to moderate or severe. Sometimes it can feel like a sprain or broken bone. Some areas of your body may even be painful to the touch.

What foods to avoid if you have rheumatism? ›

Foods You Should Avoid with Rheumatoid Arthritis
  • Grilled, broiled, or fried meats (and other fried foods). ...
  • Fatty foods full of omega-6 fatty acids. ...
  • Sugars and refined carbohydrates. ...
  • Gluten. ...
  • Preservatives and flavor enhancers. ...
  • Alcohol.
Sep 26, 2018

How can I stop rheumatism pain? ›

Start with these eight ideas:
  1. Take your pain medication on a schedule and as prescribed. ...
  2. Use a warm, moist compress to loosen up a stiff joint. ...
  3. Make it a priority every day to relax. ...
  4. Focus on things you enjoy.
  5. Join a support group. ...
  6. Exercise. ...
  7. Eat a healthy, balanced diet. ...
  8. Consider talking to a counselor.
Jun 15, 2021

What is the best vitamin for rheumatoid arthritis? ›

Vitamin B6: Research seems to show inflammation from RA lowers B6 levels which in turn makes the inflammation worse. In addition, the NSAIDs that many people use to treat their inflammation lowers B6 levels in people with RA. You and your doctor should monitor B6 levels and supplement where needed.

Is rheumatism a disability? ›

The Social Security Administration (SSA) considers rheumatoid arthritis, or RA, a qualifying disability, but it must be advanced RA to meet the SSA's eligibility requirements. That means that you your rheumatoid arthritis has to be so severe that you will be out of work for at least 12 months.

Can rheumatoid arthritis lead to death? ›

A person cannot die from RA. However, the widespread inflammation that characterizes the condition can lead to life-threatening complications. According to the Rheumatoid Arthritis Support Network, a person with RA may have a lifespan that is approximately 10, or at most 15, years shorter than average.

How do you get rheumatic disease? ›

What Causes Rheumatic Disease? Most of these conditions happen when your immune system goes awry and attacks your own tissues. Doctors aren't sure what causes this. Sometimes it's in your genes.

What medicine helps with arthritis pain? ›

Over-the-counter pain medications, such as acetaminophen (Tylenol, others), ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve) can help relieve occasional pain triggered by activity your muscles and joints aren't used to — such as gardening after a winter indoors.

Why is my RA pain worse at night? ›

One theory is that the body's circadian rhythm may play a role. In people with rheumatoid arthritis (RA), the body releases less of the anti-inflammatory chemical cortisol at night, increasing inflammation-related pain.

Is there a blood test for arthritis? ›

No blood test can definitively prove or rule out a diagnosis of rheumatoid arthritis, but several tests can show indications of the condition. Some of the main blood tests used include: erythrocyte sedimentation rate (ESR) – which can help assess levels of inflammation in the body.

How quickly does rheumatoid arthritis spread? ›

Clinical History. The typical case of rheumatoid arthritis begins insidiously, with the slow development of signs and symptoms over weeks to months. Often the patient first notices stiffness in one or more joints, usually accompanied by pain on movement and by tenderness in the joint.

Is rheumatism genetic? ›

Heredity and RA

"RA, like many autoimmune diseases, is quite heritable and unfortunately tends to cluster in families," says Hu. "Many genetic studies have gone into identifying genes that predispose individuals to the risk of RA."

What are the 4 stages of rheumatoid arthritis? ›

The four stages of rheumatoid arthritis are known as synovitis, pannus, fibrous ankylosis, and bony ankylosis.
  • Stage I: Synovitis. During stage I, you may start having mild symptoms, including joint pain and joint stiffness. ...
  • Stage II: Pannus. ...
  • Stage III: Fibrous Ankylosis. ...
  • Stage IV: Bony Ankylosis.
Oct 12, 2021

What are 5 symptoms of arthritis? ›

What are the symptoms of arthritis?
  • Pain.
  • Redness.
  • Stiffness.
  • Swelling.
  • Tenderness.
  • Warmth.
Apr 15, 2021

Where does arthritis start? ›

Arthritis is caused by inflammation of the joints. Osteoarthritis usually comes with age and most often affects the fingers, knees, and hips. Sometimes osteoarthritis follows a joint injury. For example, you might have badly injured your knee when young and develop arthritis in your knee joint years later.

What are the 3 types of arthritis? ›

The Three Most Common Types of Arthritis
  • Osteoarthritis. Osteoarthritis the most common form of arthritis. ...
  • Rheumatoid Arthritis. Rheumatoid arthritis is an autoimmune disease, which means that the immune system attacks parts of the body—especially the joints. ...
  • Psoriatic Arthritis.
Jun 28, 2017

What's worse osteoarthritis or rheumatoid arthritis? ›

The two conditions can cause similar symptoms, but they have different causes and treatments. OA usually affects fewer joints, and its symptoms are generally limited to the joints. The progression of RA is more difficult to predict, and it can cause more widespread symptoms.

What are the 4 stages of rheumatoid arthritis? ›

The four stages of rheumatoid arthritis are known as synovitis, pannus, fibrous ankylosis, and bony ankylosis.
  • Stage I: Synovitis. During stage I, you may start having mild symptoms, including joint pain and joint stiffness. ...
  • Stage II: Pannus. ...
  • Stage III: Fibrous Ankylosis. ...
  • Stage IV: Bony Ankylosis.
Oct 12, 2021

What is rheumatism pain like? ›

The quality of rheumatic pain is typically a deep aching sensation, but the word "soreness" is also used, perhaps to emphasize the pain on motion and tenderness to touch.


1. Rheumatoid Arthritis - Diagnosis | Johns Hopkins
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2. How is Rheumatoid Arthritis Diagnosed? | Johns Hopkins Rheumatology
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3. Immunology of the rheumatoid joint
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4. Rheumatoid Arthritis Flares: What Triggers a RA Flare? | Johns Hopkins Medicine
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5. Rheumatology Patient Education: Rheumatoid Arthritis
6. Rheumatoid arthritis - causes, symptoms, diagnosis, treatment, pathology
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