Rheumatology | Quest Diagnostics (2023)

Count on reliable insights that power timely action, regardless of the complexity of the case. We continually evolve our testing with advanced technology to address the unique challenges of autoimmune diseases while providing extensive support services—so you can better diagnose and expedite patient treatment.

Rheumatology | Quest Diagnostics (1)

Autoimmune diseases by the numbers1

Scientists are continuing to learn more about autoimmune diseases on a daily basis.


Autoimmune diseases are a group of more than 100 chronic conditions

In the US, autoimmune diseases affect more than 24 million people, while 8 million more have auto-antibodies

Autoimmune diseases cluster: 5%-10% of Americans have more than one autoimmune disease

Approximately 80% of all patients diagnosed with autoimmune diseases are women

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Our expansive portfolio of autoimmune tests uses state-of-the-art automation, and gold standard immunofluorescence assays (IFA) for antinuclear antibody (ANA) testing, to deliver insights across the patient journey, from screening to diagnosis to monitoring.

Comprehensive panels are an especially essential tool for diagnosis since no single diagnostic assay exists for any one autoimmune disease. To address this need, we offer convenient panels to assist in the rapid diagnosis of key autoimmune diseases including rheumatoid arthritis, lupus, myositis, interstitial lung disease, systemic sclerosis, and more.

Explore our menu of more than 150 tests for diagnosing different autoimmune diseases with our Immunology/Rheumatology Test List.

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  • Screening & Diagnostic Tests
  • Pre-biologic Tests
  • Monitoring Tests

ANAlyzer™ ANA IFA with Reflex Titer/Pattern Systemic Autoimmune Panel 1

This ANA Screen, IFA, Reflex Titer/Pattern panel evaluates 25 analytes from a single sample to provide clear, positive identification of specific antibodies for the most common autoimmune rheumatic diseases.

This panel:

  • Utilizes IFA with HEp-2 cells, which remains the gold standard³
  • Tests for all analytes regardless of ANA results
  • Tests for rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), Sjögren syndrome, systemic sclerosis (SSc), polymyositis/dermatomyositis, CREST syndrome, and neuropsychiatric SLE

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Antinuclear Autoantibody (ANA) Screen with Reflexes

The ANA Screen, IFA, Reflex Titer/Pattern, Reflex Mplx 11 Ab Cascade with IdentRA® from Quest Diagnostics provides clear, positive identification of specific antibodies for the 8 most common rheumatic diseases with one blood draw.

This panel:

  • Utilizes IFA with HEp-2 cells, which remains the gold standard3
  • Reflexes to tiered cascading of specific autoantibodies to maximize sensitivity and specificity
  • Tests for rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), Sjögren’s syndrome, systemic sclerosis (SSc), polymyositis/dermatomyositis, CREST syndrome, and neuropsychiatric SLE

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Rheumatoid Arthritis Diagnostic IdentRA® Panel 2

Rheumatoid arthritis (RA) and psoriatic arthritis can be difficult to diagnose clinically early in the disease process. The 14-3-3η protein, used in conjunction with rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibody, may improve diagnostic sensitivity in the early diagnosis of RA.

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Anti-Synthetase Panel 1

This semi-quantitative line blot assay assesses myositis-specific antibodies to aid in the diagnosis of anti-synthetase syndrome. Antibodies on the panel include Jo-1, EJ, OJ, PL-7, PL-12.

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Myositis Specific 11 Antibodies Panel

This test helps to provide a more confident diagnosis of polymyositis/dermatomyositis (PM/DM). The autoantibodies included are Jo-1, EJ, OJ, PL-7, PL-12, SRP, Mi-2α, Mi-2β, MDA-5, NXP-2, TIF-1γ.

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Systemic Sclerosis (Scleroderma) 12 Antibodies Panel 2

The Systemic Sclerosis (SSc) 12 Antibodies Panel 2 looks at several antibodies that are highly specific for SSc, including Scl-70, CENP-A, CENP-B, RP11, RP155, U1-snRNP RNP A, U1-snRNP RNP C, U1-snRNP RNP-70kd, fibrillarin, Th/To, PM/Scl-100, PM/Scl-75.

This panel:

  • Helps to provide a diagnosis of SSc
  • Helps physicians determine SSc type
  • Identifies organ involvement
  • Informs patient prognosis
  • Looks at antibodies that are present in overlap syndromes with SSc

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HLA-B*58:01 Typing

This test helps evaluate risk of severe cutaneous adverse reactions (SCARs) to allopurinol, which is widely used to treat conditions associated with hyperuricemia such as uric acid kidney stones, uric acid neuropathy during chemotherapy, and gout.

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Interstitial Lung Disease Panel

This panel evaluates 20 biomarkers to aid the diagnosis of connective tissue diseases (CTDs) that are associated with the development of interstitial lung disease (ILD), including rheumatoid arthritis, inflammatory myositis, systemic sclerosis, and Sjögren’s syndrome.

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Pre-biologic/-biosimilar HCV, HBV, and TB Screen Panel with Reflexes

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The Pre-biologic panel from Quest Diagnostics includes tests recommended by American College of Rheumatology (ACR) and American College of Gastroenterology (ACG) guidelines for evaluating autoimmune patients prior to initiating therapy with biologics and/or biosimilars.

The panel includes tests for:

  • HBV screening
  • HCV screening
  • TB infection screening with interferon gamma release assay (IGRA)

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14-3-3 eta Protein

The 14-3-3 eta protein is an emerging biomarker of joint damage in rheumatoid arthritis (RA) and psoriatic arthritis. Concentrations are significantly higher in people with active joint disease. This test complements RF and CCP antibody tests and may improve diagnostic sensitivity.

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Adalimumab and Infliximab Testing

Quest Diagnostics offers testing that provides unique insights on patient response to tumor necrosis factor (TNF) blockers, so you can personalize treatment strategy for the best outcome. These tests measure TNF blocker drug levels and/or anti-drug antibodies in patients with rheumatic diseases such as RA, plaque psoriasis, and psoriatic arthritis.

View our adalimumab tests View our infliximab tests

We deliver expert level of insight to help you make informed care decisions for your autoimmune patients. Decipher even the most difficult-to-diagnose autoimmune disorders that have nonspecific, overlapping symptoms.

  • Consultations with clinical experts: Get answers to your questions on test selection and results interpretation by connecting to our network of 600+ MDs, PhDs, and genetic counselors with expertise in immunology, infectious disease, and other subspecialties
  • Comprehensive view of patient health: Gain deeper insights into complex autoimmune diseases with our broad specialty test menu that covers intersecting specialties such as gastroenterology, dermatology, neurology, and more
  • State-of-the-art technology: Access insights with reduced subjectivity and faster turnaround time enabled by cutting-edge methodologies and automation

Increasing efficiency with intuitive experiences

We simplify the end-to-end diagnostic process with an array of integrated tools and services that allow you to spend less time on paperwork and more time on delivering quality care.

  • Quanum® for Healthcare Professionals: Streamline your practice workflow and save your staff valuable time with the Quanum® suite of health information technology solutions
    • Quanum® Lab Services Manager: Easily manage all your laboratory-related tasks on any device with the Lab Services Manager platform
    • Quanum® Interactive Insights: Simplify results reporting and foster more meaningful conversations with your patients by depicting lab results and trends over time in a graphic-rich display
  • Seamless EHR connectivity: Keep lab results and relevant clinical information at your fingertips with our ability to integrate with more than 600 EHRs

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Quest is committed to helping you and your patients work together toward better health.

  • Broad, in-network access: Our preferred status with major payers means low or no out-of-pocket costs for patients, and pricing at the time of service prevents surprise bills
  • 2,250+ Patient Service Centers: Patients can get tested when and where it is most convenient for them, ensuring swift access to testing
  • Online appointment scheduling: Appointments can be easily scheduled, viewed, or changed online by patients
  • MyQuest™ patient portal: Our portal allows patients to check results, share results with multiple providers, and schedule medication reminders anytime, anywhere, and on any device

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Watch our webinars

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Lab Testing for Overlapping Rheumatic Diseases: A Comprehensive Approach

The objectives of this webinar include:

  • Review background, epidemiology, and language of rheumatic disease overlap
  • Present/review relevant guidelines for rheumatic disease diagnosis
  • Assess an innovative panel of relevant biomarkers for diagnosing rheumatic diseases
  • Review case study of patients with overlapping symptoms and clinical application of relevant biomarkers

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Content intended for health care professionals

  1. American Autoimmune Related Diseases Association. Accessed July 18, 2019. https://www.aarda.org/
  2. Konforte D, Diamandis EP, van Venooij WJ, Lories R, Ward MM. Autoimmune diseases: early diagnosis and new treatment strategies. Clin Chemistry. 2012;58(11):1510-1514. doi: 10.1373/clinchem.2012.189480
  3. Agmon-Levin N, Damoiseaux J, Kallenberg C, et al. International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies. Ann Rheum Dis. 2014;73 (1):17-23. doi:10.1136/annrheumdis-2013-203863
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