MDMA's (Molly/Ecstasy) Side Effects
To learn how pure Molly (MDMA) makes you feel, visit this page.
Side effects of pure MDMA
Possible side effects during use
- Dry mouth
- Difficulty concentrating
- Feeling cold
- Impaired balance/gait
- Heavy legs
- Jaw clenching/tight jaw
- Lack of apppetite
- Restless legs
“Overall, adverse effects of MDMA are modest and generally have not been associated with serious discomfort in healthy volunteers or in people with PTSD.” “Common reactions reported in clinical trials are transient and diminish as drug effects wane during the MDMA session and over the next 24 hours. Once the drug leaves the body, 3 to 4 days post-treatment, most reactions diminish.”
“There can be acute nervousness or anxiety during the psychotherapy session, but that’s to be expected, because again, that’s the drug bringing out the effects of PTSD. You want to bring up anxiety, but it’s reported as a side effect. There’s also heightened cardiovascular activity - you might get a slightly higher heart rate or a slightly higher blood pressure level. But in all our studies so far, we’ve kept the blood pressure constant to that of the room. Out of the 136 subjects who were treated in the Phase 2 studies, only one 50-year-old male had an elevated heart rate. The physician on-site decided, “Oh, we’re not so sure about this,” so the patient went to the emergency room and was released later that day with no treatment. That’s the worst case we’ve seen in all of the trials.”
“MDMA has been administered to more than 750 human subjects in clinical studies with only one single serious adverse event occurring as a result of the drug.”
Details of the single serious adverse effect: “One related serious adverse reaction has occurred within all sponsor-supported studies to date. Subject 0811 experienced an increase in frequency of ventricular extrasystoles (PVC’s), a form of arrhythmia, on the day of his third and final experimental session with open-label 125 mg MDMA. The subject had no other signs and no symptoms of cardiac distress. In the absence of any symptoms of coronary insufficiency, the investigator judged the only medical measure necessary to be withholding the supplemental dose of MDMA.” “Full recovery occurred 1 day after MDMA administration.”
|Side effect during use||Average proportion of MDMA clinical trial participants who experienced this side effect, increase over placebo group|
|Jaw clenching/tight jaw||60%|
|Lack of apppetite||66%|
|Lack of energy||0%|
|Rapid eye movements||23%|
|Jaw muscle spasms||21%|
|Urge to urinate||7%|
Serious acute risks
About 2.66 million people used ecstasy in the US in 2015. Harm reduction expert Emanuel Sferios estimated that there are around 20 ecstasy related deaths per year in the US. This is 0.00075% of users. For comparison, there’s a “0.0007% chance of dying from a skydive, compared to a 0.0167% chance of dying in a car accident” based on driving 10,000 miles.
Consuming a substance that is not MDMA. Many tablets and powders are fake and/or adulterated with other drugs.(Video) UMMS toxicologist explains dangers of 'Molly' club drug
Heat stroke and/or serotonin syndrome. Like all serotonergic drugs, MDMA increases heat stroke risk due to its effects on the hypothalamus, the part of our brain that helps us regulate body temperature.
Hyponatremia. Generally caused by drinking too much water. MDMA causes water retention. Dancing aerobically in hot environments causes dehydration. Overcompensating by drinking too much water can be fatal.
Possible side effects during the next few days
“Common reactions reported in clinical trials are transient and diminish as drug effects wane during the MDMA session and over the next 24 hours. Once the drug leaves the body, 3 to 4 days post-treatment, most reactions diminish.”
- Decreased appetite
- Immune functioning: “MDMA may also produce modest changes in immune functioning, lasting up to 48 hours.”
“During the week after each experimental session, the most commonly reported reactions at any severity were anxiety, fatigue, insomnia, depressed mood, hypersomnia, difficulty concentrating, decreased appetite, and dizziness in the active dose MDMA groups across studies, with PTSD studies overrepresented. Of these reactions, only decreased appetite and dizziness were appreciably elevated above the placebo group, and the remaining reactions are likely to be background events.”
Interestingly, in MAPS sponsored MDMA clinical research, depressed mood in days 1-7 following MDMA use was observed in 13% of patients in the placebo condition, and 13% of patients in the 100-125 mg condition! Refer to page 77 of 143.
From the fantastic book Acid Test: “He’d learned that MDMA, which flooded the brain with serotonin during the session, could leave a hangover of serotonin depletion for a few days, which might be associated with depressed feelings. Oddly though, in Michael’s first study, the subjects who took only the sugar pill reported more depressed feelings following the sessions than those who got the MDMA.”
Anecdotal reports indicate that “comedowns” are strongly related to:
- Impure MDMA
- Unsafe dosages
- Not waiting long enough between MDMA uses
- Lack of sleep
- Lack of healthy diet/exercise/lifestyle
Possible long-term side effects
Does MDMA cause brain damage? Two researchers who reviewed animal and human studies as of the year 2000 concluded that frequent or heavy use “may exhaust neuronal energy sources and antioxidant defenses, leading to damage.” They warn that “the possible risks of neurotoxicity must be considered when assessing the potential administration of MDMA to humans.“45
One of those researchers, Matthew Baggott, points out that since the year 2000, millions of Americans have continued to use illicit MDMA and its popularity remains on the rise among young people.”
“I am slightly reassured,” Baggott said, “that we haven’t seen an obvious epidemic of mental health problems despite thirty years of widespread MDMA use. But we absolutely still need to consider potential neurotoxicity when considering giving MDMA to people.”
MDMA researcher Matthew Baggott: “To the best of my understanding, doses around 1.5-1.7 mg/kg MDMA (roughly 100 to 125 mg MDMA) are unlikely to cause long-lasting serotonin changes. Studies by MAPS have looked for changes in mental abilities after people participated in their studies, with some participants receiving 125 mg followed by 62.5 mg, and have not found any changes.” MAPS study protocol involves 3 - 5 week breaks, and a total of 2 or 3 MDMA sessions in total.
Advocates of MDMA-assisted psychotherapy stress the differences between heavy recreational drug users and patients who are carefully screened and take the medication two or three times in a supervised setting. Statistics from emergency room visits or reports of deaths attributed to Ecstasy are troubling, but they often involve users who may be simultaneously drinking alcohol and ingesting other illicit drugs. Those behind the new wave of studies point out that more than a thousand people have received MDMA in research settings without any serious problems. “There is little reason to fear,” says Rick Doblin of MAPS, the psychedelic research sponsor, “that normal therapeutic (or recreational) doses of MDMA will result in harmful functional or behavioral consequences.”
Since the MDMA dosage Ricaurte had tested was about three times the average therapeutic dose equivalent—1.7 milligrams per kilogram—Rick urged him to do another test at a lower dosage to determine if, at any point above the therapeutic dosage, MDMA would show no long-lasting effect on serotonin neurons anywhere in the brain.That point came at 2.5 milligrams per kilogram, still 50 percent above the usual therapeutic dosage. Eight doses of that size were administered over four months (one dose every two weeks), after which there was no detectable damage to neurons. Rick was greatly relieved, since that would be the key to persuading the FDA that it would be safe enough to conduct human therapeutic trials.”
Why is there confusion and false information surrounding MDMA? Read this by Rick Doblin, founder of MAPS.
“No significant differences in cognitive function were detected at the 2-month follow-up between subjects who received two sessions with 125 mg of MDMA compared to subjects who received placebo, as measured by RBANS and PASAT.” See page 60 of 143.
“In a study designed to minimize limitations found in many prior investigations, we failed to demonstrate marked residual cognitive effects in ecstasy users. This finding contrasts with many previous findings—including our own—and emphasizes the need for continued caution in interpreting field studies of cognitive function in illicit ecstasy users.”
“Overall, differences between non-users and heavy users were sufficiently modest on most cognitive measures that we could exclude a large effect of ecstasy (d ≥ 0.8) at the 0.05 level.”
“Conversely, our present findings appear congruent with several other recent studies suggesting that cognitive effects of ecstasy use are modest (16, 58) and perhaps mediated or confounded by trait impulsiveness (47), comorbid substance use (48), and sleep deprivation (48, 59)—although this last possibility remains uncertain (60).”
Extra info from DrugScience.org.uk
A very relevant thing that stands out in the science concerning MDMA, is that studies using people with a history light and occasional use of MDMA are far less likely to show mental deficits compared to studies where people have a history of binging on large amounts of MDMA or regular MDMA use. Whether or not deficits are caused by lack of sleep or use of other drugs, it is still the case that partying too hard may affect your mental abilities.
There is scientific controversy over the long term harmful effects of MDMA. Although, studies with MDMA users have found impairments inmemoryandimpulsivity, there are other factors which may contribute to this, such asuse of other drugsand lack of sleep. Controlling for such things,one particular studyfound no significant connection between MDMA use and performance on cognitive tests, although this study has receivedsome criticism.
It is also possible that something like impulsivity could make someone more likely to take MDMA, rather than being caused by MDMA use (summarised in this article). A similar confusion is found with the link between MDMA and depression. Some studies have suggested that MDMA can contribute to depression, though some have found thatthose with depression may be more likely to later take MDMA.
Whether such effects would last for a very long time is also debatable. There is strong evidence from brain imaging studies suggesting that mostchanges in the brain areas affected by MDMA (serotonergic system) are not long term.
For most people, it is hard to know what to think when considering the possible long term harms of MDMA. One thing that you need to consider, is that a statistically significant effect on memory in a study, may reflect a very subtle (but possibly significant) effect on everyday life. Effects being subtle however, may also mean that effects on mental abilities caused by MDMA could go unnoticed. It is therefore very difficult to know if MDMA would affect you, or whether such effects would be a problem. Additionally, although the long term effects of MDMA may be less risky than something liketobacco, there is no way to know if what is bought illegally is actually MDMA.See AlsoHow to Parent an Adult Child With Bipolar DisorderBest Golf Grips For Arthritic Hands in 2022Swollen lymph nodes in armpit: Symptoms, causes, and treatmentEdgar Cayce Maps: His Prophecies for Earth Explained | LoveToKnow(Video) What's The Danger With Molly?
There is also anecdotal evidence that after multiple uses of MDMA, the ‘magic goes’ and users no longer find the drug as enjoyable (although this is not reported by all).
Side effects of MDMA (Molly, Ecstasy) relative to other drugs
A 2010 research paper compares the harms of various drugs “using multi-criteria decision analysis (MCDA) – a method that uses relevant experts’ knowledge and experience to assess the actual and relative harms.” This involved looking at the side effects of each drug and comparing them.
The blue bars (harm to users) are independent of the popularity of the drug, while the red bars (harm to society) are dependent on the popularity of the drug. Even if the same number of people used MDMA as use alcohol, their blue bars/harm to users scores would still be the same.
“Finally, we should note that a low score in our assessment does not mean the drug is not harmful, since all drugs can be harmful under specific circumstances.”
Side effects of impure MDMA (very common with Molly or Ecstasy)
Millions of MDMA users put themselves at unnecessary risk by using impure MDMA. The chemicals that are often mixed with or sold as MDMA are often higher risk than MDMA.
Unfortunately, your “MDMA”, “Molly” or Ecstasy is probably not pure MDMA. This 2005 paper found that 61% of tested ecstasy tablets contained other drugs. And a massive 46% contained 0% MDMA.
87% of “Molly” analyzed by the DEA between 2009 and 2013 contained 0% MDMA, instead mostly containing “bath salts.” 😔
These other substances that are mixed in with MDMA can have worse side effects than pure MDMA - as the image above makes clear. Most illicit drugs have a greater risk of serious harm than MDMA, and so getting impure MDMA substantially increases your risks. And given that illegal drugs have no regulation, impure MDMA is a very frequent risk.
Read more about the risk of impure MDMA and how to partially address it with a test kit.
How does Molly (MDMA) make you feel?
MDMA consumption can lead to a sympathetic surge resulting in elevated blood pressure, and potentially may cause the pre-existing vascular lesions such as aneurysms and arteriovenous malformations to rupture.
Molly (also spelled Molli or Mollie) is a diminutive of the Hebrew feminine name Mary. It may less commonly be used as a diminutive for feminine names that begin with M, such as Margaret, Martha, Martina or Melinda.
Results: There is growing evidence that chronic, heavy, recreational use of ecstasy is associated with sleep disorders, depressed mood, persistent elevation of anxiety, impulsiveness and hostility, and selective impairment of episodic memory, working memory and attention.
People who like Molly, which can cost $20 to $50 a dose, say it is a more socially acceptable drug than cocaine, because it is not physically addictive.
Those who use ecstasy may also have co-occurring disorders such as depression or anxiety. The misuse of ecstasy and other substances may make it clear that the individual has a form of mental illness such as schizophrenia that hasn't yet been diagnosed.
Our results indicate that those with a higher prevalence of lifetime ecstasy use exhibit higher levels of aggressive and violent behavior. However, the effect of lifetime ecstasy use differs by levels of low self-control as a measure of propensity for aggression.
With Irish origins, Molly is a girl's name which is simply put, quintessentially Irish. Meaning “star of the sea,” there are many Irish Mollys that have gone down in Gaelic folklore.
In Hebrew Baby Names the meaning of the name Molly is: Wished-for child; rebellion; bitter.
MDMA generally is sold as a tablet, which is taken orally. MDMA tablets are available in various colors and shapes and generally are imprinted with a logo. Popular logos include smiley faces, clover leaves, cartoon characters, and symbols associated with commercial brands such as Mitsubishi, Nike, and Mercedes.
Evidence demonstrates that MDMA enhances feelings of closeness to others (Borissova et al., 2020), which is particularly useful in couple therapy to allow the individuals to feel connected within the experience, regardless of content being shared.
- Molly goes by many innocent-sounding names. ...
- Molly comes in a powder form. ...
- It's inexpensive. ...
- Molly is not pure MDMA. ...
- The typical users is between the ages of 16 and 24. ...
- Molly is popular at concerts, clubs and raves. ...
- Molly increases a person's serotonin levels.
Supportive therapy together with 3,4-methylenedioxymethamphetamine (MDMA)—also known as the recreational drug ecstasy—significantly reduced severe posttraumatic stress disorder (PTSD) symptoms in a phase 3 multisite clinical trial.
Mollies are mostly found from Southern United States down into Central America. The native habitat of these fish extends from the southern United States to the Yucatan peninsula in Mexico, and they thrive mainly in freshwater environments, sometimes venturing into brackish estuaries.
The average molly fish lifespan is around three to five years. While they aren't the longest-living freshwater species out there, there is some wiggle room depending on what species you get.
The short answer is that mollies live for about 5 years. However, there are many factors that determine their lifespan such as diet, tank conditions, genetics, and so much more. These will be discussed in this article. Let's find out more about the beautiful Molly fish!
MDMA causes greater release of serotonin and norepinephrine than of dopamine. Serotonin is a neurotransmitter that plays an important role in the regulation of mood, sleep, pain, appetite, and other behaviors. The excess release of serotonin by MDMA likely causes the mood-elevating effects people experience.
The effects of MDMA may reduce anxiety in the face of emotionally challenging thoughts or memories and can increase self-compassion and enhance fear-extinction learning27,28,29,30.
People can experience hallucinations when they're high on illegal drugs such as amphetamines, cocaine, LSD or ecstasy.
MDMA causes an increase in heart rate, blood pressure, and body temperature. These stimulant effects, combined with prolonged physical activity, a hot environment, and other drugs, can result in unpredictable and serious physical complications.
"This is the first study to show that this drug can deplete the level of serotonin in humans." Ecstasy, which is known chemically as methylenedioxymethamphetamine, or MDMA, is structurally related to the hallucinogen mescaline and the stimulant amphetamine.
Ecstasy has been associated with acute kidney injury that is most commonly secondary to nontraumatic rhabdomyolysis but also has been reported in the setting of drug-induced liver failure and drug-induced vasculitis. More common, ecstasy has led to serious hyponatremia and hyponatremia-associated deaths.
The popular nickname Molly (slang for "molecular") often refers to the supposedly "pure" crystalline powder form of MDMA, usually sold in capsules. However, people who purchase powder or capsules sold as Molly often actually get other drugs such as synthetic cathinones ("bath salts") instead (see "Added Risk of MDMA").
Karen is a pejorative term for a white woman perceived as entitled or demanding beyond the scope of what is normal. The term is often portrayed in memes depicting white women who use their white privilege to demand their own way.
Gender: Mary is traditionally a feminine name. Marion, Marius, or Mario may be used as masculine equivalents.
The name Molly is of Irish origin and means "bitter." It began as a diminutive of Mary, and has been used as its own name since the Middle Ages.
molly, any of several species of tropical fish of the genus Poecilia, in the live-bearer family, Poeciliidae (order Cyprinodontiformes). Hardy and attractive, mollies are popular aquarium fish ranging from about 5 to 13 cm (2 to 5 inches) long.
Molly is an adorable name for a girl that hasn't become so trendy that it feels overused. There's a certain feistiness to Molly that makes her more than just another cute name.
Cocaine, a snowflake ❄. MDMA, a lightning bolt ⚡.
What Are Xanax Lollipops? A Xanax lollipop refers to a lollipop or candy that has been laced with Xanax, the brand name for the generic drug alprazolam. Xanax, or alprazolam, is a central nervous system (CNS) depressant that is commonly prescribed by healthcare professionals to treat anxiety and panic disorders.
Drug: Flucytosine. Strength: 250 mg. Pill Imprint: K 110.
MDMA (ecstasy & molly) According to the National Institute on Drug Abuse, MDMA, also known as ecstasy and molly, is a synthetically produced drug that is intended to bring about feelings of energy, pleasure, warmth, and distortions in sensory and time perception in the user.
MDMA (±3,4-methylenedioxymethamphetamine, 'ecstasy') is used recreationally, reportedly because it increases feelings of empathy, sociability, and interpersonal closeness. One line of evidence suggests that MDMA produces these effects by releasing oxytocin, a peptide involved in social bonding.
|Founded||Mississauga, ON - 1979|
|Founder||Adrienne and Chris Stringer|
|Number of locations||400+ worldwide|
|Area served||United Kingdom Canada Japan Portugal United States|
Summary. Ecstasy (also known as MDMA) is an illegal synthetic drug that is classed as an empathogen (increases feeling of empathy and compassion towards others) but also acts as a nervous system stimulant. In high doses, ecstasy can cause perceptual changes and floating sensations, as well as seizures and vomiting.
MDMA increases the release of serotonin and other neurotransmitters that elevate the mood. After taking MDMA, these feel-good chemicals decrease, which can cause feelings of depression. Controlled doses of pure MDMA with professional supervision may provide immediate relief for depression.
When used in therapy MDMA has been reported to increase empathy, closeness between patient and therapist, relaxation, motivation to engage with therapy and introspective thought, and to reduce depression and anxiety.
Males and females can be differentiated by the shape of their anal fin. Males have a anal fin that points backwards. Females' anal fin looks just like the rest of their other fins. More than one molly can be kept in a tank together, however, they have been known to nip the fins of others in their tank.
As examples, the female swordtail and guppy will both give birth to anywhere from 20 to 100 live young after a gestation period of four to six weeks, and mollies will produce a brood of 20 to 60 live young after a gestation of six to 10 weeks.
Adult mollies reach up to 4.5 inches in length. Female molly fish grow bigger than male mollies — males grow to around 3.5 inches in length. Males are skinnier than females too, while females have rounder abdomens.
How Do Molly Fish Sleep? - YouTube
Gestation and Birth
Female mollies will gestate their young for about 60 days. They can give birth to between 40 and 100 fry. Mollies that are young or are having one of their first few pregnancies will tend to give birth to a smaller rather than larger number of fry.
That's because mollies don't lay eggs. They are livebearers that directly give birth to free-swimming fry. As you can see in this video, the underdeveloped egg has a translucent yellow appearance. There's a 99.9% chance the egg won't develop further and yield a healthy fry.
*Blood thinners (such as warfarin), some medications and prescription drugs (including diet pills that act as stimulants such as ephedrine and amphetamines), and harmful drugs like cocaine can cause aneurysms to rupture and bleed.
Cocaine can inflame the walls of the blood vessels and raise your blood pressure. The combination of these factors increases your risk of developing a brain aneurysm.
Cocaine causes aneurysms by weakening the inner lining of blood vessels. Cocaine increases blood pressure by tightening blood vessels (vasoconstriction). High blood pressure causes small tears on the inside of blood vessels.
Cocaine and stimulant use can cause aortic aneurysm by increasing the aortic wall stress, and the most feared complications are dissection, rupture, and death.
- Nausea and vomiting.
- Stiff neck.
- Blurred or double vision.
- Sensitivity to light.
- A drooping eyelid.
- Loss of consciousness.
There may be no warning signs of a bleed on the brain. For example, it could happen after someone falls and hits their head. If there is a weakness in the blood vessel wall, it can bulge or swell, which is known as an aneurysm. Aneurysms can rupture suddenly without warning, and cause a bleed on the brain.
The main illicit drugs associated with stroke are cocaine, amphetamines, Ecstasy, heroin/opiates, phencyclidine (PCP), lysergic acid diethylamide (LSD), and cannabis/marijuana. Tobacco and ethanol are also associated with stroke, but will not be discussed here.
Bleeding in the brain has a number of causes, including: Head trauma, caused by a fall, car accident, sports accident or other type of blow to the head. High blood pressure (hypertension), which can damage the blood vessel walls and cause the blood vessel to leak or burst.
With rapid, expert treatment, patients can often recover fully. An unruptured brain aneurysm may cause zero symptoms. People can live with them for years before detection. If a brain aneurysm is unruptured, no blood has broken through the blood vessel walls.
Hemorrhagic cerebrovascular accident is an uncommon but serious complication of drug overdose. A case of fatal intracranial hemorrhage following overdose with phenylpropanolamine, pentazocine, and tripelennamine is presented.
During a coiling procedure, a catheter is inserted into the aneurysm and coils are packed inside the dome. Coils promote blood clotting, which closes off the aneurysm and eliminates the risk of rupture. Aneurysms vary in their size and shape.
Brain aneurysms can occur in anyone and at any age. They are most common in adults between the ages of 30 and 60 and are more common in women than in men. People with certain inherited disorders are also at higher risk.
The growth rate is 0.56–0.65 mm/yr if annual rupture rate averaged over all aneurysm sizes is assumed to be 2%. The peak of aneurysm size distribution coincides with a period of slow growth between 5 mm and 8 mm.
The survival rate for those with a ruptured brain aneurysm is about 60% (40% die). For those who survive and recover, about 66% have some permanent neurological defect.
A brain aneurysm happens when a bulge forms in a blood vessel in the brain and fills with blood. Aneurysms often produce no symptoms unless they burst open or leak blood. A ruptured aneurysm causes severe headache and can lead to a fatal stroke.
An estimated 6.5 million people in the United States have an unruptured brain aneurysm, or 1 in 50 people. The annual rate of rupture is approximately 8 – 10 per 100,000 people. About 30,000 people in the United States suffer a brain aneurysm rupture each year. A brain aneurysm ruptures every 18 minutes.