What Does It Mean if My IgE Level Is High? (2022)

Asthma can be described as allergic or non-allergic. Allergic (extrinsic) asthma is associated with immunoglobulin E (IgE)—an antibody generated by the immune system, in this case, in response to a normally harmless substance. In contrast, non-allergic (intrinsic) asthma episodes are not typically triggered by exposure to a substance and are not associated with IgE.

IgE plays a key role in allergic responses, however it can sometimes be elevated for other reasons, such as chronic infections or inflammatory diseases. Additional testing is often needed and depends on symptoms.

Children who have asthma are more likely to have elevated IgE levels than adults with asthma. Asthma that begins for the first time during adulthood, called adult-onset asthma, is more likely to be intrinsic, non-allergic asthma.

Given the role of IgE in certain asthma cases, treatment may involve an anti-IgE medication to lower amounts of this antibody and its effects. A blood test to check your levels can help determine whether this may or may not be useful in your case.

What Does It Mean if My IgE Level Is High? (1)

The Role of IgE

IgE is naturally produced by B cell lymphocytes, a type of immune white blood cell. This antibody normally activates physical responses to help your body fight infections.

For some people, exposure to allergens—which are harmless, non-infectious substances (like dust or pollen)—can also trigger the body to produce and release IgE.

In these situations, IgE antibodies bind to the allergen and trigger an inflammatory response that can manifest with allergy symptoms such as a skin rash, sneezing, and swollen lips. When it results in asthma, it is considered the allergic type.

Common allergens include:

  • Animal dander
  • Cockroaches
  • Dust mites
  • Molds
  • Pollen

When your body releases IgE, a cascade of immune responses follows, some of which are mediated by other immune cells in the body. IgE is believed tobind to and activate several types of immune cells, such as:

  • Basophils
  • Lymphocytes
  • Mast cells

When IgE binds with any of these cells, it can overstimulate your immune system. Additionally, your capillaries widen and become leakier, increasing inflammation by allowing the immune cells to cluster around the allergen.

Symptoms Caused by Excess IgE

When you have allergic asthma, your bronchi (airways) can become narrow and inflamed due to the rush of immune cells—and this rapidly exacerbates yourasthma symptoms.

Not only do the inflammatory cells prevent air from passing through your airways, but your airways may also suddenly spasm, making it difficult for air to pass as you try to breathe.

Increased levels of IgE may contribute to symptoms of asthma, such as:

  • Wheezing
  • Chest tightness
  • Shortness of breath
  • Recurrent cough

The symptoms are usually mild, but they can be quite severe and may cause serious consequences, such as a life-threatening respiratory crisis.

Asthma Symptoms

(Video) Hyper IgE syndrome (Job's syndrome ) || Immunodeficiency disorder || clinical features

Diagnosis

If have not yet been formally diagnosed with asthma, your healthcare provider will review your specific symptoms. Those that suggest an allergic cause of your asthma include itchy eyes, nausea, sneezing, coughing, and congestion.

Sometimes the pattern of symptoms can point to allergic asthma when symptoms tend to occur in relation to allergen exposure. Allergy testing can help identify what may be triggering your condition.

IgE Testing

If there is a concern that you have allergic asthma, your healthcare provider might test your IgE level to help make a diagnosis and to help guide your treatment plan. Your healthcare provider will consider your results in the context of your symptoms and ot her diagnostic measures.

High IgE Levels

The most common cause of high IgE levels are allergic conditions. A high IgE level can't confirm a diagnosis of asthma. High IgE can only suggest that you may have some sort of allergic disorder.

However, antibody levels can vary, and your IgE level might be normal even if you have allergic asthma.

There can also be other reasons for abnormal immunoglobulin E levels.

Allergic Conditions

There are many types of allergic responses that may lead to high IgE levels. These include:

  • Allergic rhinitis, or hay fever, that leads to symptoms such as runny nose and itchy eyes
  • Allergic asthma
  • Atopic dermatitis, a skin reaction
  • Allergic bronchopulmonary aspergillosis, a hypersensitivity to a soil fungus known as Aspergillus fumigatus
  • Allergic fungal rhinosinusitis, or a fungal sinus infection

Infections

Parasitic infections are the most common type of infection associated with high IgE levels, but it can also occur along with certain viral, bacterial, or fungal infections.

Infections associated with high IgE include:

  • Parasitic infections from Ascariasis, Schistosomiasis, or Strongyloidiasis
  • Human immunodeficiency virus (HIV)
  • Tuberculosis, a bacterial infection caused by Mycobacterium tuberculosis
  • Cytomegalovirus (CMV)
  • Epstein-Barr virus
  • Candidiasis, or a yeast infection caused by an overgrowth of the fungus candida

Autoimmune and Inflammatory Diseases

Autoimmune diseases occur when the immune system mistakenly attacks its own tissues. Inflammatory diseases are when there is an excess immune response that leads to inflammation. These can also be associated with high IgE.

Examples include:

  • Rheumatoid arthritis, an autoimmune disease that often affects joints
  • Lupus, an autoimmune disease that can affect tissues and organs
  • Celiac disease, an autoimmune disease that leads to damage of the small intestine from an immune response to gluten
  • Churg-Strauss syndrome, a rare autoimmune disorder that causes vasculitis (an inflammation of blood vessels)
  • Kawasaki disease, a rare inflammatory condition in children under age 5 that may be due to an infection and can affect the heart
  • Kimura disease, an inflammatory condition that causes swelling under the skin of the head and neck

Some immunodeficiencies, or conditions that impair the immune system's ability to fend off infections, may also contribute to high IgE.

Blood-Related Cancers

High IgE is also associated with certain blood-related cancers. This includes Hodgkin lymphoma, a type of blood cancer that starts in the lymph nodes, and IgE myeloma, a rare type of cancer that affects a type of white blood cells in bone marrow.

(Video) How can one reduce IgE count immediately?-Dr. Surekha Tiwari

Other Conditions

There are some other conditions and behaviors associated with high Ige:

  • Smoking
  • Medications used to treat or prevent bacterial infections, such as aztreonam or penicillin G
  • Cystic fibrosis, an inherited disorder that damages the lungs and digestive tract
  • Nephrotic syndrome, a kidney disorder
  • Bone marrow transplants

Treatment for High IgE Levels

There are a number of treatments for allergic asthma, includingavoiding allergens that areasthma triggers, if possible. However, it is not always possible to avoid allergens, especially if they are highly prevalent in the environment.

Inhalers containing immunosuppressants or bronchodilators are commonly used to treat allergic asthma.

Treatment with anti-IgE is another approach that can be used along with bronchodilators. Your IgE level can help your healthcare provider determine whether you might benefit from treatment that can lower IgE. But a high level is not a requirement for treatment with an anti-IgE.

Your healthcare provider might consider this if your asthma is persistent or if you have side effects from your treatment. Reducing your IgE, if elevated, is a more targeted method of preventing symptoms of allergic asthma than immunosuppression with steroids, which has long been a way of managing asthma by reducing inflammation.

Xolair (omalizumab)is an anti-IgE medication approved by the Food and Drug Administration (FDA) for the treatment of allergic asthma for adults and children over the age of 6. It binds to IgE antibodies to reduce their effects and help prevent (though not treat) allergic asthma attacks.

Indications for Xolair include:

  • Severe or persistent asthma that's inadequately controlled with inhaled corticosteroids and a positive skin test or positive blood allergy test
  • Chronic skin rash that's inadequately controlled with antihistamines

Xolair is given every two to four weeks as a subcutaneous (under the skin) injection administered by a healthcare provider. Side effects can include injection site reactions, infections, headaches, and sore throat.

Xolair for the Treatment of Asthma

A Word From Verywell

Allergic asthma is caused by an overreaction to one or more specific allergens, and you are likely to experience symptoms every time you are exposed to them. High levels of IgE can support a diagnosis of allergic asthma, and anti-IgE medication may help control your symptoms.

If you are already on an allergic asthma treatment plan without adequate control of your asthma, speak with your healthcare provider about your persistent symptoms. You may benefit from revising your treatment approach.

Frequently Asked Questions

  • What happens if IgE is too high?

    In the case of allergies and allergic asthma, it sets off a chain of events that contributes to symptoms, such as a runny nose or cough.

    (Video) Blood Test: Immunoglobulin E (IgE) - what does a high immunoglobulin e level mean

    Learn More:What Types of Allergy Tests Are Available?

  • What is the main function of IgE?

    It plays a primary role in triggering inflammation in an immune response to an allergen and in defending against parasites.

    Learn More:What Are Allergens?

  • What foods increase IgE?

    This depends on what (if anything) you are allergic to. For example, if you are allergic to peanuts, cow's milk, eggs, or soy, IgE may increase if you consume it.

    Learn More:The 9 Most Common Food Allergies

  • What is a normal immunoglobulin E level?

    A normal range for immunoglobulin E is typically between 4 kU/1 and 100 kU/1 for adults. For children, normal ranges vary based on age.

    (Video) IgE | high ige levels in blood | ige level high treatment | high ige | how to cure ige allergy | ige
  • What are the five immunoglobulins and what are they used for?

    • IgA is found in mucosal tissue, such as the respiratory tract and digestive system, and defends against infections.
    • IgD binds to B cells to initiate an immune response but its role is not well understood. It is found in small amounts in blood.
    • IgG is the most common type of antibody. It is found in blood and bodily fluids and defends against viruses and bacteria.
    • IgA is part of allergic reactions and defends against parasites. It is found in small amounts in blood.
    • IgM is the first to fight infections and help trigger release of other antibodies. It is found in blood and lymph fluid.

    Learn More:Types of Antibodies

  • Can high IgE cause fatigue?

    High IgE may contribute to fatigue due to its role in triggering an inflammatory response. However, low IgE is more strongly associated with this symptom.

  • Do antihistamines lower IgE?

    They may, but they do not target IgE directly. Antihistamines block the receptor for histamine, a substance released during an allergic response that contributes to allergy symptoms.

Increased levels of IgE may contribute to symptoms of asthma, such as:. There are many types of allergic responses that may lead to high IgE levels.. Parasitic infections are the most common type of infection associated with high IgE levels, but it can also occur along with certain viral, bacterial, or fungal infections.. Infections associated with high IgE include:. (Video) Blood Test: Immunoglobulin E (IgE) - what does a high immunoglobulin e level mean. (Video) IgE | high ige levels in blood | ige level high treatment | high ige | how to cure ige allergy | ige. IgA is found in mucosal tissue, such as the respiratory tract and digestive system, and defends against infections.

Hyper IgE Syndrome (HIES) is a rare primary immunodeficiency disease characterized by eczema, recurrent staphylococcal skin abscesses, recurrent lung infections, eosinophilia (a high number of eosinophils in the blood) and high serum levels of IgE.. Definition of Hyper IgE Syndrome HIES is a rare primary immunodeficiency characterized by recurrent eczema, skin abscesses, lung infections, eosinophilia and high serum levels of IgE.. These two forms share overlapping clinical and laboratory features including eczema, recurrent infections, skin abscesses, high IgE level and increased eosinophil number.. It commonly presents with respiratory infections and skin findings including newborn rash, eczema, recurrent skin abscesses and ear, sinus and lung infections resulting in formation of cavitary lesions in the lungs (pneumatoceles).. Additional findings include connective tissue and skeletal abnormalities such as a typical facial appearance characteristic of patients with this syndrome, hyper-extensibility of their joints, retained primary teeth and recurrent bone fractures secondary to even minimal trauma.. Lungs Affected by Hyper IgE Syndrome Recurrent bacterial pneumonias are often encountered in patients with AD-HIES.. Recurrent lung infections with both gram-positive and negative bacteria are common in patients with AR-HIES with DOCK8 deficiency, and they may also lead to chronic lung disease with damage to the airways (bronchiectasis) and lung tissues.. In contrast to AD-HIES patients, those with AR-HIES due to DOCK8 deficiency patients do not manifest abnormalities in their dentition.. Other Clinical Findings of Hyper IgE Syndrome Deep tissue abscesses are commonly encountered in patients with AD-HIES, most frequently caused by staphylococcal infections.. Diagnosis of Hyper IgE Syndrome The diagnosis of HIES can be made based on a combination of clinical and laboratory findings for both types of HIES.. In this system, patients are evaluated for the existence and severity of the following clinical and laboratory features: newborn rash, eczema, skin abscesses, recurrent upper respiratory infections, pneumonia, lung changes (cavities), candidiasis, other severe infections, fatal infections, characteristic facial appearance, increased nasal width, high palate, retained primary dentition, joint hyperextensibility, fractures with minor trauma, scoliosis, midline anatomic abnormalities, lymphoma, high serum IgE level, and eosinophilia.. Given that patients with HIES suffer from significant eczema and skin infections and that the compromised skin offers a portal of entry to pathogens to cause deep seated infections, skin care and prompt treatment of skin infections is an important component of HIES management.. Although the over-use of antibiotics and antifungals is discouraged in general with “normal” patients due to concerns about selection for resistant organisms, the under-use of antibiotics in HIES patients leaves this group at risk for infections that are debilitating and dangerous.. Expectations for Patients with Hyper IgE Syndrome Patients with both types of HIES require constant vigilance with regard to infections and development of chronic lung disease.

They help but finally changing my diet - no carbs - as they turn to sugar and feed the fungus - has helped the most - and no bad side effects as with the drugs!. Recently i had a IgE Test, since i have been feeling low sensation in my whole body.. Was switched to cylosporin (300mg / day), 10 mg of prednisone a day which helped a little.. As time went on, it helped less and less.. My last IGE results were 299 ( still don't believe it ), but I can not be a candidate for xolair if IGE is over 300.. Hoping xolair helps. Between my asthma and eczema, I can't hold a job for more than a couple months at a time.. Try changing his diet it is a lot cheaper and SAFER!, my doctor recommended cellcept but I declined after finding out about it's side effects.. i am the patient of asthama since i was 7 years old and now im 29years old, i always had skin problems with me, last year my doctor adviced me to get tested the IgE, so my IgE levels were about 4000, from now onword i get myself tested after every 30 days and my IgE levels are between 3500-5000, i am constantly having the anti allergy tablts but no result, my doctor dont want me to take Xolair, can any1 tell me what should i do???

Eosinophils are produced in the bone marrow and help protect the body against parasitic diseases and infections.. When these leukocytes are higher than expected in our blood, eosinophilia, the elevated levels of eosinophils count may occur in blood, a pathology known as blood eosinophilia, where there has been an inflammation or infection, known as tissue eosinophilia.. Eosinophils are one of the types of white blood cells that make up our immune system.. But what do high eosinophils mean ?. In that case, they increase to be able to cope with the infection, increasing their levels in the areas where the infection is present.. In that case, it could already be considered eosinophilia or high eosinophils count, of which in the next section, we explain the possible causes.. The high eosinophils in the blood indicate the increased production and release of eosinophils from the bone marrow.. The causes of high eosinophils can be:. Even when these factors are present and the risk of developing high levels of eosinophils increases, it does not necessarily mean that the person will build eosinophilia since it is not a very common condition.. The most common symptoms when high eosinophils or eosinophilia are:. Other symptoms of high eosinophil values , although less common than the ones we have just explained, are:. However, you must be aware that you have any of these symptoms does not refer to the fact that eosinophils are at high levels in our body, as these signs could correspond to various diseases.. To control the production of eosinophils, treatment will be directed at addressing the underlying cause of the disease once the doctor identifies it.. If you want to read more articles similar to High Eosinophils: what it means, symptoms and treatment , we recommend that you enter our Immune System category.

Substances that induce an allergic reaction are called allergens and the reaction can vary from mild sneezing to a more severe condition called anaphylactic shock .. As a defensive reaction to this perceived threat, the body produces antibodies called immunoglobulin E (IgE) which are a form of protein.. An IgE blood test measures the amount of IgE antibodies present in the blood at any point.. The test is also classified in various other ways and is termed as Quantitative IgE, Immunoglobulin E, Total IgE, or Specific IgE test at times.. Your doctor can order you to undergo an IgE test in case you have a severe allergic reaction to any substance or some food component.. A serum IgE test is performed by drawing a blood sample from a vein by inserting a needle which takes a few minutes.. The blood sample is then tested for specific levels of IgE.. -Immunoglobulin E: These antibodies are generated as a reaction to allergens like pollen or certain foods and are tested when an allergy occurs.. The cost of the test varies depending on the number of allergens being tested and the center for testing.. The upper limits of IgE in the blood vary from person to person and in general blood tests are usually considered positive if the allergen-specific IgE level is greater than 0.35 kU/L.. Age group IU/mL 0 to 4 days <1.5 5 days to 12 months <15 1 to 5 years <60 6 to 9 years <90 10 to 16 years <200 >16 years <100Adults3- 423 IgE levels can be high when the body is fighting off an infection or in case there are some issues with the immune system.. There is no fasting required for this test and a blood sample can be taken at any time during the day.. In some cases, the doctor may suggest other tests like full blood count (FBC) and white blood cell differential for an indirect diagnosis.. There are also skin prick tests, patch tests and oral food challenges that can be suggested.. A simple blood test or a skin prick testing in babies is a common and safe procedure for determining allergies.

The RAST allergy test, or radioallergosorbent test, measures the level of allergen-specific IgE antibodies in your blood.. That's because RAST and another blood allergy test called ImmunoCAP are less reliable screening tests with many false positive results.. A number of skin tests may be used to diagnose an allergy, rather than relying on the RAST test.. Skin prick testing, with allergen exposure through light skin scratches of the back or arm Intradermal testing, with an allergen injected into a deeper skin layer to check for reaction Patch testing, with a bandage containing allergen applied to the skin for testing. RAST tests are just one way of testing for food allergies.

Antibodies are proteins made by plasma cells , a type of white blood cell.. Antibodies are often classified based on which types of light chain and heavy chain proteins they contain.. The abnormal antibodies are called M protein, myeloma protein , monoclonal protein, M spike, or paraprotein.. Like normal antibodies, M protein contains two heavy chain and two light chain proteins.. Multiple myeloma is grouped into categories based on which type of chain makes up the M protein.. IgG is the most common antibody type, and IgG myeloma is the most common type of multiple myeloma.. There are also other types of myeloma that don’t involve heavy chain protein.. Some people with myeloma have light chain myeloma, also called Bence-Jones myeloma.. In this case, plasma cells only make light chain protein and not heavy chain protein.. Multiple myeloma diagnosis includes tests to determine whether plasma cells are making too much IgG, IgA, or another heavy chain protein.. These tests may show which type of M protein a person has, or they may show the overall levels of the heavy or light chain proteins.. Immunofixation electrophoresis (IFE), similar to another test called immunoelectrophoresis (IEP), is a test that is used to determine which heavy chain proteins make up M protein.

Evaluation of patients with suspected diseases associated with elevations in total immunoglobulin E (IgE), including allergic disease, primary immunodeficiencies, infections, malignancies, or other inflammatory diseases. Total IgE measurements have limited utility for diagnostic evaluation of patients with suspected allergic disease, except for allergic bronchopulmonary aspergillosis (ABPA).. For patients with an established diagnosis of allergic disease, measurement of total IgE is necessary for identification of candidates for omalizumab (anti-IgE) therapy and for determination of proper dosing.. Elevated concentrations of total immunoglobulin E (IgE) may be found in a variety of clinical diseases including allergic disease, certain primary immunodeficiencies, infections, inflammatory diseases, and malignancies.. Elevated total IgE concentrations may be consistent with a diagnosis of allergic bronchopulmonary aspergillosis, provided other laboratory and clinical criteria are fulfilled.. An elevated concentration of total immunoglobulin E (IgE) is not diagnostic for allergic disease and must be interpreted in the clinical context of the patient including age, gender, travel history, potential allergen exposure, and family history.. In patients with a high index of suspicion for allergic disease, testing for allergen-specific IgE may be warranted.. Ansotegui IJ, Melioli G, Canonica GW, et al: IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper.. Evaluation of patients with suspected diseases associated with elevations in total immunoglobulin E (IgE), including allergic disease, primary immunodeficiencies, infections, malignancies, or other inflammatory diseases. Specimen Required Defines the optimal specimen required to perform the test and the preferred volume to complete testing. Specimen Minimum Volume Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed.. Performing Laboratory Location Indicates the location of the laboratory that performs the test. Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents.. Setup Files. Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Total IgE levels can be affected by many conditions, so total IgE testing by itself does not establish a diagnosis.. However, total IgE testing cannot identify specific allergies or conclusively determine if a person has allergies at all.. For people with asthma tied to allergies, a total IgE test may be used to determine whether certain types of treatment are likely to be beneficial.. A total IgE test measures the sum of all these different IgE antibodies in the blood.. Laboratory methods can typically measure total IgE levels accurately.. The most appropriate follow-up tests depend on your symptoms, overall health, and total IgE levels.. What are my total IgE levels?. Were my total IgE levels within the normal range?. While the total IgE test measures the sum of all kinds of IgE in the blood, a specific IgE test looks for particular IgE antibodies that are linked to certain substances or allergens.. A total IgE test may provide more information when diagnosing certain conditions and planning treatment for allergic asthma.. Allergy blood test.

She denies history of frequent sinus infections, history of pneumonia or otitis media infections.. Could low IgE be due to Humira and mercaptopurine?. There is no specific immunodeficiency identified by isolated IgE deficiency and selective IgE deficiency is not included in the classification of primary immunodeficiency diseases (1).. In order to clarify the potential role of IgE in host defense, we have studied the clinical characteristics of patient with serum IgE levels of<2.5 IU/mL, using patients with normal or elevated IgE levels as controls.. RESULTS: Forty-four patients were found to have IgE levels of<2.5 IU/mL; 57% of these had depressed serum levels of other immunoglobulins, and 43% had isolated IgE deficiencies.. There was no difference in the prevalence of these disease in patients with selective IgE deficiency as compared with those with IgE deficiency complicated by deficits in other immunoglobulin classes.. CONCLUSIONS: IgE-deficient patients have an increased prevalence of multiple immunoglobulin deficits, autoimmune disease, and nonallergic reactive airway disease when compared with a clinic population of patients with normal to elevated IgE levels.. BACKGROUND: Immunoglobulin E (IgE) deficiency (<2.5 kU/L) has unclear clinical significance.. OBJECTIVE: To evaluate the clinical and laboratory differences between patients with IgE deficiency and those with non-IgE deficiency with and without CVID diagnosis.. RESULTS: The IgE levels were measured in 2,339 patients and 63 (2.7%) had IgE deficiency.. CONCLUSION: The rate of prior malignancy is significantly higher in patients with IgE deficiency than in those without IgE deficiency.. However, patients with IgE deficiency have higher frequency of malignancy than patients with normal IgE levels even in the absence of CVID.. Selective IgE deficiency, immune dysregulation, and autoimmunity.. Selective IgE deficiency (IgED) is currently defined as a significant decrease in serum levels of IgE (<2 kIU/L) in a patient whose other immunoglobulin levels are normal.

An allergy blood test measures a substance called immunoglobulin E (IgE) in your blood.. Allergy symptoms depend on the type of allergy you have.. Other names: IgE allergy test, Quantitative IgE, Immunoglobulin E, Total IgE, Specific IgE, RAST, CAP, ELISA. Allergy blood tests are used to help find out if you have an allergy.. Your health care provider may order allergy testing if you have symptoms of an allergy.. Your provider may choose to order an allergy blood test if you can't have allergy skin testing .. In certain cases, providers may order allergy blood tests for young children, because skin testing may be too uncomfortable for them.. There is very little risk to having an allergy blood test.. But the results of a total IgE test don't show what you're allergic to or how serious your allergy may be.. If the results from either type of test show that you could have an allergy, your provider may refer you to an allergy specialist or recommend a treatment plan.. Allergy blood tests may not always be accurate.. Depending on your medical history and symptoms, your provider may order an allergy skin test with an allergy blood test, or you may have a skin test alone.. Available from: http://acaai.org/allergies/anaphylaxis Cleveland Clinic: Health Library: Treatments and Procedures: Allergy Blood Tests [Internet].. Allergy Blood Testing; [modified 2021 Nov 9; cited 2022 Mar 12]; Available from: https://www.testing.com/tests/allergy-blood-testing/ Testing.com [Internet].

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